23 Systemic Lupus Erythematosus Clinical Trials in Chicago, IL (2026)

Q: How do I join a clinical trial in Chicago?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you.

Recruiting Systemic Lupus Erythematosus Studies in Chicago

NCT05934149Recruiting

Lupus Landmark Study: A Prospective Registry and Biorepository

The purpose of the registry and biorepository is to provide a mechanism to store clinical data, linked biospecimens and molecular data to support the conduct of future research on Systemic Lupus Eryth...

Chicago, IL3,500 participantsLupus Research Alliance

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NCT07406360Recruiting

A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Administered as Intramuscular Injection to Healthy Children 15 Months to 6 Years of Age

This study is evaluating the immunogenicity and safety of intramuscular administration of the investigational MMRVNS vaccine compared to intramuscular administration of the MMRV (Merck's measles, mump...

Chicago, ILPHASE31,209 participantsGlaxoSmithKline

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NCT07691970Recruiting

Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment

The purpose of this study is to provide continued access to anifrolumab to eligible participants who are continuing to derive clinical benefit from treatment at the end of a parent clinical study, as ...

Chicago, ILPHASE31,072 participantsAstraZeneca

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NCT00198068Recruiting

Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS)

The PROMISSE Study is an observational study of 700 pregnant patients, enrolled at nine major clinical centers. The purpose of the study is 1) to determine whether certain proteins (called complement ...

Chicago, IL700 participantsHospital for Special Surgery, New York

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NCT07515534Recruiting

Effect of Early Parent Education on Children's Sleep

The goal of this clinical trial is to learn if providing sleep information and advice to expecting parents can increase sleep duration and decrease sleep problems in infants. The main questions it aim...

Chicago, ILNA391 participantsUniversity of Chicago

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NCT07387705Recruiting

On Track for Wellness (OTW) Stepped Wedge Cluster Randomized Trial

This study will evaluate a program called On Track for Wellness (OTW) which is being adopted by the Illinois Department of Human Services' Division of Behavioral Health \& Recovery (DBHR) for use in a...

Chicago, ILNA365 participantsUniversity of Illinois at Chicago

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NCT06949644Recruiting

Pupillometry in Delayed Sleep Wake Phase Disorder

The goal of this observational study is to characterize the pupil light response in patients with delayed sleep-wake phase disorder. A subset of participants will take part in a clinical trial to dete...

Chicago, ILNA220 participantsNorthwestern University

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NCT06897930Recruiting

A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE

This is a Phase 1b/2, single-arm, open-label, multi-center, clinical study of AZD0120, a CD19/BCMA dual CAR T cell therapy, to evaluate the safety, tolerability, and efficacy in adult participants wit...

Chicago, ILPHASE1150 participantsAstraZeneca

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NCT06477952Recruiting

DRonabinol Treatment of OSA

This is an open-label trial that tests the effectiveness of Dronabinol in treating obstructive sleep apnea (OSA). All participants will take oral Dronabinol for two weeks. Sleep studies will be conduc...

Chicago, ILPHASE1120 participantsVA Office of Research and Development

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NCT06557265Recruiting

A Phase 1/2 Study of NKX019 in Subjects With Autoimmune Disease (Ntrust-1)

This is a Phase 1/2, open-label, multi-center, multi-cohort, non-randomized dose escalation and dose expansion basket study to determine the safety and tolerability of NKX019 (allogeneic CAR NK cells ...

Chicago, ILPHASE1120 participantsNkarta, Inc.

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NCT05538208Recruiting

The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study

The study is a 1-year 2-part double-blinded placebo controlled 2-arm clinical trial. Treatment arms are (1) MMF dosed as per body-surface area (MMFBSA; 600mg/m2 body surface area per dose about every ...

Chicago, ILPHASE2105 participantsChildren's Hospital Medical Center, Cincinnati

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NCT05835310Recruiting

An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants

A Study to evaluate the PK, PD, efficacy, and safety of Anifrolumab in children with moderate to severe active SLE...

Chicago, ILPHASE3100 participantsAstraZeneca

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NCT06925542Recruiting

A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease

This is a single-arm, open-label, multicenter, ascending dose Phase 1 study evaluating the safety and preliminary efficacy of CTX112 in adult subjects with refractory autoimmune diseases, including ac...

Chicago, ILPHASE180 participantsCRISPR Therapeutics

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NCT05201469Recruiting

VIBRANT: VIB4920 for Active Lupus Nephritis

This is a multi-center double-blind placebo controlled clinical trial evaluating the efficacy of VIB4920 combined with mycophenolate mofetil (MMF) and prednisone in achieving a renal response in parti...

Chicago, ILPHASE274 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT07113288Recruiting

Inspire UAS High Apnea Hypopnea Index (AHI)/High Body Mass Index (BMI) Post-Approval Study

The purpose of this observational clinical study is to provide evaluation of long-term safety and effectiveness in a newly expanded patient population including patients with a higher AHI and a higher...

Chicago, IL70 participantsInspire Medical Systems, Inc.

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NCT06471374Recruiting

Pathophysiology of Circadian Rhythm Delayed Sleep Wake Phase Disorder

The goal of this study is to understand factors that contribute to delayed sleep wake phase disorder (DSWPD). The investigators will examine whether patients with DSWPD exhibit alterations in circadia...

Chicago, ILNA66 participantsUniversity of Colorado, Boulder

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NCT07085104Recruiting

A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease

This is a first-in-human, single-arm, open-label study evaluating the safety, tolerability, and preliminary efficacy of ALLO-329 in adults with autoimmune diseases: systemic lupus erythematosus (SLE) ...

Chicago, ILPHASE166 participantsAllogene Therapeutics

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NCT06636318Recruiting

Immune Status After Being on Call for 24 Hrs

Sleep deprivation is a prevalent problem in modern societies. Sleep deprivation can cause hormonal changes, such as an increase in cortisol, as well as inflammation. Animal studies have shown an incre...

Chicago, IL60 participantsUniversity of Chicago

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NCT06915831Recruiting

Type 1 Diabetes and Obstructive Sleep Apnea

The purpose of the study is to investigate the role of sleep apnea in glycemic dysregulation in adults with Type 1 diabetes....

Chicago, ILNA40 participantsUniversity of Chicago

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NCT06317701Recruiting

Metabolic Endpoints for Obstructive Sleep Apnea Following Twelfth Cranial Nerve Stimulation

The purpose of this study is to determine if the treatment of Obstructive sleep apnea (OSA) by hypoglossal nerve stimulation (HGNS) will alter glucose metabolism. The study team will also determine if...

Chicago, IL30 participantsUniversity of Chicago

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NCT06121297Recruiting

RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus...

Chicago, ILPHASE128 participantsCabaletta Bio

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NCT07328581Recruiting

A Phase IIa Study of ICG318 CAR-T in Refractory Systemic Lupus Erythematosus With or Without Lupus Nephritis

This Phase IIa, open-label, single-arm study includes an initial Safety Run-In followed by dose expansion to evaluate the safety, tolerability, cellular kinetics, pharmacodynamics, and preliminary cli...

Chicago, ILPHASE220 participantsiCell Gene Therapeutics

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NCT06926036Recruiting

Micromanaging Human Sleep Physiology to Treat Sleep Apnea and Other Disorders

This study will examine whether a combination of breathing training during wake and targeted reactivation of the training during sleep can induce breathing changes during sleep and subsequent cognitiv...

Chicago, ILNA18 participantsNorthwestern University

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About Systemic Lupus Erythematosus Clinical Trials in Chicago

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect the joints, skin, kidneys, blood cells, brain, heart, and lungs. It is characterized by periods of flares and remission. Treatment includes antimalarials, immunosuppressants, corticosteroids, and biologics like belimumab.

There are currently 23 systemic lupus erythematosus clinical trials recruiting participants in Chicago, IL. These studies are seeking a combined 8,604 participants. Research is being sponsored by Lupus Research Alliance, GlaxoSmithKline, AstraZeneca and 14 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Systemic Lupus Erythematosus Clinical Trials in Chicago — FAQ

Are there systemic lupus erythematosus clinical trials in Chicago?

Yes, there are 23 systemic lupus erythematosus clinical trials currently recruiting in Chicago, IL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chicago?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you about next steps.

Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chicago studies also compensate for your time and travel.

What systemic lupus erythematosus treatments are being tested?

The 23 active trials in Chicago are testing new therapies including novel drugs, biologics, and treatment approaches for systemic lupus erythematosus.

Data updated October 15, 2026 from ClinicalTrials.gov