49 Ulcerative Colitis Clinical Trials in Chicago, IL (2026)

Q: Are there ulcerative colitis clinical trials in Chicago?

Yes, there are 49 ulcerative colitis clinical trials currently recruiting in Chicago, IL.

Q: How do I join a clinical trial in Chicago?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you.

Q: Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatments, medical tests, and doctor visits are provided at no cost.

Recruiting Ulcerative Colitis Studies in Chicago

NCT06526988Recruiting

Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure

An increasing number of guideline-directed medical therapies (GDMT) have been developed for patients with chronic heart failure with reduced ejection fraction (HFrEF). When used in combination at reco...

Chicago, ILNA2,200 participantsUniversity of Colorado, Denver

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NCT03487185Recruiting

Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

A randomized controlled trial of 1,500 women to assess whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a reduction in the rate ...

Chicago, ILNA1,500 participantsThe George Washington University Biostatistics Center

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NCT06302439Recruiting

PROPEL - A Prospective Observational Patient Registry to Evaluate ENPP1 and ABCC6 Deficiency

The purpose of this prospective registry is to characterize the natural history of ectonucleotide pyrophosphatase/phosphodiesterase1(ENPP1) Deficiency and the infantile-onset form of adenosine triphos...

Chicago, IL1,000 participantsInozyme Pharma

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NCT07674758Recruiting

Modeling Mortality in Duchenne Muscular Dystrophy Cardiomyopathy: Identification of Surrogate Outcome Measures for DMD Drug Trials

Dystrophin associated heart dysfunction is a leading cause of death in patients with Duchenne and Becker Muscular dystrophy (DMD/BMD) and Duchenne and Becker muscular dystrophy carriers (MDC); however...

Chicago, IL1,000 participantsVanderbilt University Medical Center

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NCT05079841Recruiting

The Stimulation To Induce Mothers Study

The investigators propose a parallel group randomized clinical trial of intrapartum nipple stimulation versus exogenous oxytocin infusion for nulliparous women undergoing induction of labor near term....

Chicago, ILPHASE4988 participantsYale University

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NCT04967989Recruiting

Clarifying the Optimal Application of SLT Therapy Trial

The goal of this study is to understand if SLT performed at low energy is as effective as SLT performed at standard energy, and also to see if repeating SLT at low energy once a year will prevent or d...

Chicago, ILPHASE3790 participantsUniversity of Pittsburgh

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NCT07012395Recruiting

A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

This is a Phase 2, multicenter, proof-of-concept platform study in adult participants with moderately to severely active ulcerative colitis (UC). The primary goal of the study is to assess the efficac...

Chicago, ILPHASE2645 participantsSpyre Therapeutics, Inc.

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NCT06220721Recruiting

Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia

The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfun...

Chicago, ILNA618 participantsMedical College of Wisconsin

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NCT06390345Recruiting

Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention

The investigators will conduct a Type I hybrid effectiveness-implementation study to test an integrated telehealth intervention among 400 overweight and obese patients with Chronic Obstructive Pulmona...

Chicago, ILNA400 participantsSeattle Institute for Biomedical and Clinical Research

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NCT07127978Recruiting

A Study Evaluating the Real-World Experience of Givinostat in Patients With Duchenne Muscular Dystrophy

This is a prospective observational study conducted to evaluate safety, tolerability, and functional outcomes of patients with DMD newly initiating oral givinostat or having started therapy within 6 m...

Chicago, IL300 participantsITF Therapeutics LLC

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NCT04098146Recruiting

Registry to Collect Data on Patients Undergoing Segmental Mandibular Defect Reconstruction Following Oral Squamous Cell Carcinoma Resection and Drugs-induced Osteonecrosis

Prospective will be collected in a minimum of 300 patients presenting with an acquired segmental mandibular defect ≥ 2 cm secondary to OSSC removal and drugs-induced osteonecrosis, and who require man...

Chicago, IL300 participantsAO Innovation Translation Center

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NCT06398626Recruiting

An Observational Study of Etrasimod in Adult Patients With Moderate to Severe Ulcerative Colitis

The purpose of this observational study is to learn about the effects of etrasimod as a treatment for adult patients with moderate to severe ulcerative colitis. Patients will be treated according to s...

Chicago, IL300 participantsPfizer

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NCT06575192Recruiting

Evaluation of the Safety and Effectiveness of ARTIA Reconstructive Tissue Matrix Breast Reconstruction (ADORA) in Adult Participants

The purpose of this study is to evaluate the safety and effectiveness of ARTIA in adult participants undergoing immediate, two-stage, implant-based breast reconstruction post-mastectomy....

Chicago, ILPHASE3264 participantsAbbVie

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NCT05230173Recruiting

Treat-to-Target of Endoscopic Remission in Patients With IBD in Symptomatic Remission

The purpose of this study is to compare the effectiveness and safety of a strategy of switching to an alternative targeted immunomodulator (TIM) therapy to treat to a target of endoscopic remission, v...

Chicago, ILNA250 participantsUniversity of California, San Diego

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NCT06564974Recruiting

Registry Study to Observe Long-term Safety of Vamorolone (AGAMREE®) in Patients With Duchenne Muscular Dystrophy-SUMMIT

The goal of this study is to collect additional information on the safety of long-term treatment with AGAMREE® and to explore long-term clinical impact of AGAMREE® on quality of life, as assessed by s...

Chicago, IL250 participantsCatalyst Pharmaceuticals, Inc.

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NCT07020312Recruiting

Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery

After orthopedic surgeries like knee or hip replacement, some patients struggle to fully activate their muscles due to a condition called Arthrogenic Muscle Inhibition (AMI). AMI can slow recovery and...

Chicago, ILPHASE2240 participantsRush University Medical Center

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NCT05547165Recruiting

Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants

Patent Ductus Arteriosus is a developmental condition commonly observed among preterm infants. It is a condition where the opening between the two major blood vessels leading from the heart fail to cl...

Chicago, ILNA240 participantsNationwide Children's Hospital

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NCT06979336Recruiting

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)

The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis for whom prior treatment with conventiona...

Chicago, ILPHASE2224 participantsGenentech, Inc.

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NCT06693310Recruiting

STOP-UC: De-escalation of Therapy in Patients With Ulcerative Colitis With Histological Remission

The goal of this study is to better understand treatment strategies for people with ulcerative colitis (UC). Researchers will compare patients with UC in histologic remission (no evidence of inflammat...

Chicago, ILNA200 participantsUniversity of Chicago

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NCT07427017Recruiting

Selenium Supplementation in Moderate-Severely Active Ulcerative Colitis Patients Treated With Advanced Therapies

Micronutrient deficiencies are common in ulcerative colitis (UC). Selenium deficiency is associated with worse disease outcomes including disease flares and need for surgery. Previous in vitro and in ...

Chicago, ILPHASE2180 participantsNorthwestern University

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NCT07023614Recruiting

A Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy

FORTITUDE-HCM is a global, multicenter, double-blind, parallel-group, placebo-controlled Phase 2b study that will assess the efficacy and safety of ninerafaxstat compared to placebo on top of Standard...

Chicago, ILPHASE2165 participantsImbria Pharmaceuticals, Inc.

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NCT05620784Recruiting

Intra-operative Loop Diuretics to Improve Same-day Discharge Rates After HoLEP

Holmium Laser Enucleation of the Prostate (HoLEP) is a size-independent treatment option for benign prostatic hypertrophy (BPH) as recommended by the American Urological Association (AUA) Guidelines. ...

Chicago, ILPHASE3138 participantsNorthwestern University

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NCT07071519Recruiting

A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis

Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine). This study will assess how Risankizumab...

Chicago, ILPHASE3120 participantsAbbVie

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NCT06477952Recruiting

DRonabinol Treatment of OSA

This is an open-label trial that tests the effectiveness of Dronabinol in treating obstructive sleep apnea (OSA). All participants will take oral Dronabinol for two weeks. Sleep studies will be conduc...

Chicago, ILPHASE1120 participantsVA Office of Research and Development

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NCT07355491Recruiting

Performance Evaluation of Dream OCT: AP Study

This study will evaluate the clinical performance of a new swept-source OCT imaging device, the VG200D, and to evaluate substantial equivalence with a predicate device, the Cirrus 5000. Clinical perfo...

Chicago, IL120 participantsIntalight, Inc

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NCT07227467Recruiting

Prospective Assessments Following Immediate Lymphatic Reconstruction

Immediate lymphatic reconstruction (ILR) is a novel surgical approach performed at the time of initial lymph node dissection with the goal of preventing lymphedema.(Chang et al. 2020) It involves the ...

Chicago, IL100 participantsUniversity of Chicago

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NCT05874414Recruiting

Combination of GNS561 and Trametinib in Patients With Advanced KRAS Mutated Cholangiocarcinoma

This is an open-label, multicenter Phase 1b/2a study to evaluate safety, pharmacokinetics (PK), pharmacodynamics (PD) and efficacy of GNS561 in combination with trametinib in Advanced KRAS Mutated Cho...

Chicago, ILPHASE198 participantsGenfit

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NCT06650592Recruiting

Objective Assessment of Outcomes Following Immediate Lymphatic Reconstruction / LYMPHA

Immediate lymphatic reconstruction (ILR) is a novel surgical approach performed at the time of initial lymph node dissection with the goal of preventing lymphedema. It involves the identification of l...

Chicago, IL90 participantsUniversity of Chicago

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NCT04150614Recruiting

BMT-08: A Comparative Effectiveness Study of Transdermal Granisetron to Ondansetron

Patients undergoing either an autologous or allogeneic hematopoietic stem cell transplant (HSCT) and receiving preparative chemotherapy experience a considerable amount of chemotherapy-induced nausea ...

Chicago, ILPHASE490 participantsUniversity of Illinois at Chicago

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NCT07113288Recruiting

Inspire UAS High Apnea Hypopnea Index (AHI)/High Body Mass Index (BMI) Post-Approval Study

The purpose of this observational clinical study is to provide evaluation of long-term safety and effectiveness in a newly expanded patient population including patients with a higher AHI and a higher...

Chicago, IL70 participantsInspire Medical Systems, Inc.

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NCT06095128Recruiting

A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)

The main aim of this study is to learn about the effect of treatment with vedolizumab IV (vedolizumab) together with tofacitinib in adults with moderate and severe ulcerative colitis (UC). Another aim...

Chicago, ILPHASE465 participantsTakeda

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NCT05693142Recruiting

AFFINITY DUCHENNE: RGX-202 Gene Therapy in Participants With Duchenne Muscular Dystrophy (DMD)

RGX-202 is a gene therapy designed to deliver a transgene for a novel microdystrophin that includes functional elements of naturally-occurring dystrophin including the C-Terminal (CT) domain. This is...

Chicago, ILPHASE265 participantsREGENXBIO Inc.

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NCT06138639Recruiting

A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)

This is a multicenter, open-label, non-randomized study to investigate the safety, tolerability, and efficacy of a single intravenous (IV) infusion of SGT-003 in participants with Duchenne muscular dy...

Chicago, ILPHASE160 participantsSolid Biosciences Inc.

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NCT07483073Recruiting

A Master Protocol (IIBD): A Study of Multiple Drugs in Adults With Ulcerative Colitis or Crohn's Disease

Study IIBD is a master protocol that will support a collection of individual sub studies that share key design components. Participants will be assigned to the appropriate study prior to randomization...

Chicago, ILPHASE260 participantsEli Lilly and Company

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NCT06549010Recruiting

Perimetric Testing With Virtual Reality

Perimetry is an essential component in the diagnosis and monitoring of glaucoma. Since the advent of Standard Automated Perimetry (SAP), one of the clinical standards has been the Humphrey Field Analy...

Chicago, ILNA60 participantsEnvision Health Technologies, Inc.

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NCT07335510Recruiting

Impact of Barostimulation on Hemodynamics in Adults With Heart Failure

This study evaluates the effects of the implantation and adjustment of the CVRx Barostim device in adult patients with heart failure with reduced ejection fraction who are receiving maximally tolerate...

Chicago, ILNA58 participantsColumbia University

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NCT07287189Recruiting

Phase 2 Study of SAT-3247 in Pediatric Ambulatory Patients

Phase 2a trial of SAT-3247 in ambulatory DMD patients aged ≥ 7 and \< 10 years. The trial will study two doses of SAT-3247 in a randomized, double-blind, placebo-controlled weekday regimen for 12 week...

Chicago, ILPHASE251 participantsSatellos Bioscience, Inc.

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NCT03604835Recruiting

Mucopolysaccharidosis VII Disease Monitoring Program

The objectives of this study are to characterize MPS VII disease presentation and progression and assess long-term effectiveness and safety, including hypersensitivity reactions and immunogenicity of ...

Chicago, IL50 participantsUltragenyx Pharmaceutical Inc

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NCT06915831Recruiting

Type 1 Diabetes and Obstructive Sleep Apnea

The purpose of the study is to investigate the role of sleep apnea in glycemic dysregulation in adults with Type 1 diabetes....

Chicago, ILNA40 participantsUniversity of Chicago

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NCT07090616Recruiting

KRONOS Versus Breg T-Scope Post-operative Knee Braces Following Anterior Cruciate Ligament (ACL) Reconstruction

The purpose of this study is to evaluate how well the KRONOS postoperative knee brace reduces pain and enhances recovery compared with the standard Breg T-scope hinged brace following anterior cruciat...

Chicago, ILNA40 participantsRush University Medical Center

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NCT05287126Recruiting

A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis

The purpose of this study is to determine the safety, efficacy, and pharmacokinetics (PK) of etrasimod for the treatment of moderately to severely active ulcerative colitis in adolescents (≥ 12 years ...

Chicago, ILPHASE236 participantsPfizer

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NCT06835387Recruiting

Study of NALIRIFOX in Advanced Unresectable Small Bowel Tumors

The study regimen will be administered on an outpatient basis and all medications are administered intravenously (IV). Subjects will receive treatment on Day 1 and Day 15 of each 28-day cycle consisti...

Chicago, ILPHASE236 participantsTiago Biachi de Castria

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NCT05579392Recruiting

A Randomized Crossover Trial of Bright Light Therapy in Crohn's Disease on Intestinal Barrier Homeostasis

Crohn's Disease (CD) and Ulcerative Colitis (UC), collectively known as inflammatory bowel disease (IBD), are two of the most significant chronic conditions of the gastrointestinal tract (GIT) and aff...

Chicago, ILNA30 participantsRush University Medical Center

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NCT06317701Recruiting

Metabolic Endpoints for Obstructive Sleep Apnea Following Twelfth Cranial Nerve Stimulation

The purpose of this study is to determine if the treatment of Obstructive sleep apnea (OSA) by hypoglossal nerve stimulation (HGNS) will alter glucose metabolism. The study team will also determine if...

Chicago, IL30 participantsUniversity of Chicago

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NCT05412394Recruiting

Once Weekly Infant Corticosteroid Trial for DMD

The hypothesis tested here is that a lower dose of intermittent oral corticosteroids (5mg/kg/week) will be equally effective to the 10mg/kg/week dose....

Chicago, ILPHASE426 participantsAnne M. Connolly

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NCT06008626Recruiting

Clinical Trial of the Cryosa System for the Treatment of Obstructive Sleep Apnea

This is a prospective, multicenter, non-randomized single-arm safety and performance study to collect data to evaluate the safety of the Cryosa procedure to treat obstructive sleep apnea (OSA) in pati...

Chicago, ILNA25 participantsCryosa, Inc.

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NCT05996003Recruiting

NS-089/NCNP-02-201 in Boys With Duchenne Muscular Dystrophy (DMD)

This is a Phase 2, open-label, multi-center, 2-part study of NS-089/NCNP-02 administered by weekly IV infusion to ambulant boys aged ≥4 to \<15 years with DMD due to mutations amenable to exon 44 skip...

Chicago, ILPHASE220 participantsNS Pharma, Inc.

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NCT06926036Recruiting

Micromanaging Human Sleep Physiology to Treat Sleep Apnea and Other Disorders

This study will examine whether a combination of breathing training during wake and targeted reactivation of the training during sleep can induce breathing changes during sleep and subsequent cognitiv...

Chicago, ILNA18 participantsNorthwestern University

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NCT05487599Recruiting

A Clinical Trial of PR001 (LY3884961) in Patients With Peripheral Manifestations of Gaucher Disease (PROCEED)

Study J3Z-MC-OJAE is a Phase 1/2, multicenter, open-label, dose-finding study of LY3884961 evaluating the safety and tolerability in adults with peripheral manifestations of GD. Up to 3 dose levels o...

Chicago, ILPHASE115 participantsPrevail Therapeutics

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About Ulcerative Colitis Clinical Trials in Chicago

Ulcerative colitis is a chronic inflammatory bowel disease that causes inflammation and ulcers in the innermost lining of the colon and rectum. It typically presents with bloody diarrhea, abdominal pain, and urgency. Treatment includes aminosalicylates, corticosteroids, immunosuppressants, and biologics.

There are currently 49 ulcerative colitis clinical trials recruiting participants in Chicago, IL. These studies are seeking a combined 13,785 participants. Research is being sponsored by University of Colorado, Denver, The George Washington University Biostatistics Center, Inozyme Pharma and 36 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Ulcerative Colitis Clinical Trials in Chicago — FAQ

Are there ulcerative colitis clinical trials in Chicago?

Yes, there are 49 ulcerative colitis clinical trials currently recruiting in Chicago, IL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chicago?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you about next steps.

Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chicago studies also compensate for your time and travel.

What ulcerative colitis treatments are being tested?

The 49 active trials in Chicago are testing new therapies including novel drugs, biologics, and treatment approaches for ulcerative colitis.

Data updated July 16, 2026 from ClinicalTrials.gov