75 Active Studies

Ulcerative Colitis Clinical Trials Near You

Find 75 actively recruiting ulcerative colitis research studies near you. Connect with study sites, check eligibility, and explore new treatment options.

75
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Recruiting Studies

RecruitingNCT06651281

Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)

Researchers want to learn more about tulisokibart (also known as MK-7240) in an extension study. Tulisokibart is a medicine designed to treat active, moderate to severe Crohn's disease (CD) and ulcera...

10 locations(Bristol, Ypsilanti, Liberty)
1,380 participants
Merck Sharp & Dohme LLC
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RecruitingNCT03519945

A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)

This study is designed to evaluate the long-term efficacy and safety of mirikizumab in participants with moderately to severely active ulcerative colitis (UC). The study will last up to 3 years. Parti...

10 locations(Dothan, Litchfield Park, Phoenix)
1,063 participants
Eli Lilly and Company
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RecruitingNCT06052059

A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)

The purpose of this protocol is to evaluate the efficacy of tulisokibart in participants with moderately to severely active ulcerative colitis. Study 1's primary hypotheses are that at least 1 tulisok...

10 locations(Dothan, Fairhope, Litchfield Park)
1,020 participants
Merck Sharp & Dohme LLC
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RecruitingNCT05079841

The Stimulation To Induce Mothers Study

The investigators propose a parallel group randomized clinical trial of intrapartum nipple stimulation versus exogenous oxytocin infusion for nulliparous women undergoing induction of labor near term....

3 locations(New Haven, Chicago, New York)
988 participants
Yale University
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RecruitingNCT06575192

Evaluation of the Safety and Effectiveness of ARTIA Reconstructive Tissue Matrix Breast Reconstruction (ADORA) in Adult Participants

The purpose of this study is to evaluate the safety and effectiveness of ARTIA in adult participants undergoing immediate, two-stage, implant-based breast reconstruction post-mastectomy....

10 locations(Orange, Torrance, Gainesville)
783 participants
AbbVie
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RecruitingNCT07012395

A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

This is a Phase 2, multicenter, proof-of-concept platform study in adult participants with moderately to severely active ulcerative colitis (UC). The primary goal of the study is to assess the efficac...

10 locations(Canoga Park, Lancaster, Colorado Springs)
645 participants
Spyre Therapeutics, Inc.
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RecruitingNCT07075718

Phase 2/Phase 3 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant

Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant...

3 locations(Grand Junction, Oklahoma City, El Paso)
610 participants
Glaukos Corporation
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RecruitingNCT06880744

A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab

Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).This study will evaluate how safe and ef...

10 locations(Birmingham, Dothan, Mobile)
530 participants
AbbVie
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RecruitingNCT07082816

Reformulated PG324 Ophthalmic Solution for Intraocular Pressure Reduction

This study is designed to see how safe and effective a new eye drop, called Reformulated PG324, is for lowering eye pressure in people with open-angle glaucoma (OAG) or ocular hypertension (OHT)....

10 locations(Dothan, Phoenix, Garden Grove)
470 participants
Alcon Research
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RecruitingNCT06589986

A Study to Assess the Efficacy and Safety of Afimkibart (Also Known as RO7790121) for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis

This Phase III, multicenter, double-blind, placebo-controlled, treat-through study will evaluate the efficacy and safety of Afimkibart (RO7790121) compared with placebo in participants with moderately...

10 locations(Dothan, Glendale, Sun City)
400 participants
Hoffmann-La Roche
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RecruitingNCT06581328

A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community Setting

Ulcerative Colitis (UC) and Crohn's Disease (CD) are long-term conditions in the gut that can cause diarrhea, swelling (inflammation), bleeding from the anus, and belly pain. The main aim of this stud...

10 locations(Mobile, Colorado Springs, Colorado Springs)
400 participants
Takeda
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RecruitingNCT05181137

A Phase 3 Study to Investigate the Efficacy and Safety of SHR0302 With Moderately to Severely Active Ulcerative Colitis

This is a randomized, double-blind, placebo-controlled, multicenter Phase 3 study that will enroll approximately 368 subjects aged 18 to 75 years old with Moderately to Severely Active Ulcerative Coli...

10 locations(Dothan, Lancaster, New Haven)
368 participants
Reistone Biopharma Company Limited
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RecruitingNCT06937086

Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

The main purpose of this study is to show whether in these individuals, treatment with both mirikizumab and tirzepatide, compared with treatment with mirikizumab and placebo, leads to decrease or disa...

10 locations(Dothan, Anaheim, Beverly Hills)
350 participants
Eli Lilly and Company
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RecruitingNCT06588855

A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis

This Phase III, multicenter, double-blind, placebo-controlled study will evaluate the efficacy and safety of induction therapy with Afimkibart (RO7790121) compared with placebo in participants with mo...

10 locations(Scottsdale, Apple Valley, Garden Grove)
350 participants
Hoffmann-La Roche
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RecruitingNCT06259097

Different Medications to Induce Labor

This is a randomized controlled trial examining whether the use of misoprostol or pitocin, in combination with a foley catheter, is more effective at inducing labor in patients with a gravid BMI that ...

2 locations(New York, The Bronx)
300 participants
Icahn School of Medicine at Mount Sinai
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RecruitingNCT05695027

Nicotinamide and Pyruvate for Open Angle Glaucoma: A Randomized Clinical Study

The objective of this study is to determine if a combination of oral nicotinamide and pyruvate (N\&P) can maintain eye health as compared to placebo while standard-of-care intraocular pressure-lowerin...

3 locations(Palo Alto, New York, New York)
250 participants
Columbia University
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RecruitingNCT05442567

A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)

The study is an extension of two parent studies (MLN0002-3024 \[NCT04779307\] and MLN0002-3025 \[NCT04779320\]). Participants must have participated in one of the previous studies. The purpose of this...

10 locations(Phoenix, San Diego, Atlanta)
240 participants
Takeda
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RecruitingNCT06043440

Down Syndrome Obstructive Sleep Apnea

The purpose of this study is to assess whether oxygen supplementation during sleep improves working memory and other clinical and patient-reported outcomes among children who have Down Syndrome (DS) w...

7 locations(Los Angeles, Ann Arbor, Cincinnati)
230 participants
Brigham and Women's Hospital
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RecruitingNCT06290934

Study of GS-1427 in Participants With Moderately to Severely Active Ulcerative Colitis

The goal of this study is to learn if GS-1427 is effective in treating participants with moderate to severe ulcerative colitis. The study will compare participants in different treatment groups treate...

10 locations(Peoria, Camarillo, Garden Grove)
228 participants
Gilead Sciences
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RecruitingNCT06979336

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)

The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis for whom prior treatment with conventiona...

3 locations(Colorado Springs, Kissimmee, Monroe)
224 participants
Genentech, Inc.
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RecruitingNCT06254950

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis

The main aim of this study is to learn if TAK-279 reduces bowel inflammation and symptoms compared to placebo. Another aim is to compare any medical problems that participants have when they take TAK-...

10 locations(Los Angeles, Murrieta, Orange)
207 participants
Takeda
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RecruitingNCT06867094

A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Ulcerative Colitis

This is a Phase 2, multinational, multicenter, randomized, double-blind, placebo-controlled, dose ranging study to evaluate the efficacy and safety of SAR441566 in adults with moderate-to-severe UC. T...

10 locations(Sun City, Bristol, Clermont)
204 participants
Sanofi
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RecruitingNCT05588843

Dose-finding Study of SAR443122 in Adult Participants With Ulcerative Colitis

This is a randomized, double-blind, placebo controlled, dose-ranging Phase 2 study. The primary objective is to evaluate the efficacy and safety of SAR443122 compared to placebo in participants with m...

10 locations(Lancaster, Atlanta, Liberty)
182 participants
Sanofi
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RecruitingNCT06029972

Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis

The goal of this study is to learn if tilpisertib fosmecarbil (formerly known as GS-5290) is effective and safe in treating participants with moderate to severe ulcerative colitis. The study will comp...

10 locations(Sun City, Chula Vista, Coronado)
176 participants
Gilead Sciences
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RecruitingNCT05401357

Bioequivalence Study With Clinical Endpoint Comparing Bimatoprost Ophthalmic Solution 0.01% and LUMIGAN® in the Treatment of Chronic Open-Angle Glaucoma or Ocular Hypertension in Both Eyes.

This is a randomized, double-blind, two-treatment, single-period, parallel design, multiple dose at multiple clinical trial sites designed to demonstrate bioequivalence with clinical endpoint in subje...

9 locations(Newport Beach, Petaluma, New Smyrna Beach)
168 participants
Amneal Pharmaceuticals, LLC
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RecruitingNCT03937154

Study of Romiplostim for Chemotherapy-induced Thrombocytopenia in Adult Subjects With Non-small Cell Lung Cancer (NSCLC), Ovarian Cancer, or Breast Cancer

To evaluate the efficacy of romiplostim for the treatment of CIT in patients receiving chemotherapy for the treatment of NSCLC, ovarian cancer, or breast cancer measured by the ability to administer o...

10 locations(Jonesboro, Anaheim, Orange)
162 participants
Amgen
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RecruitingNCT05289661

Descemet Endothelial Thickness Comparison Trial I

Descemet Endothelial Thickness Comparison Trial (DETECT) I is a multi-center, outcome assessor-masked, placebo-controlled clinical trial randomizing 160 patients in a 2x2 factorial design. The purpose...

7 locations(Palo Alto, Sacramento, Palm Beach Gardens)
160 participants
Stanford University
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RecruitingNCT04844606

A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

The main purpose of this study is to evaluate the long-term efficacy of mirikizumab in pediatric participants with ulcerative colitis (UC) or Crohn's disease (CD). The study will last about 172 weeks ...

10 locations(San Francisco, Hartford, Atlanta)
150 participants
Eli Lilly and Company
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RecruitingNCT06598943

A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

The main purpose of this study is to determine the safety and efficacy of eltrekibart and mirikizumab in adult participants with moderately to severely active ulcerative colitis (UC)....

10 locations(Chandler, Little Rock, Little Rock)
140 participants
Eli Lilly and Company
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RecruitingNCT06127043

A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Ulcerative Colitis (ROSETTA)

ROSETTA STUDY: This study will evaluate the safety, tolerability, and efficacy of Rosnilimab in subjects with moderate to severe ulcerative colitis (UC)...

10 locations(Phoenix, Garden Grove, Lancaster)
132 participants
AnaptysBio, Inc.
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RecruitingNCT06822738

A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma

Glaucoma is the second most common cause of blindness in the world, second only to cataracts. This study will assess how safe and effective a glaucoma gel stent is when implanted using the ab interno ...

10 locations(Glendale, Culver City, Aurora)
130 participants
AbbVie
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RecruitingNCT06603246

A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-Obstructive Disease

This study evaluates the safety, tolerability, and activity of inhaled GDC-6988 in participants with muco-obstructive disease....

6 locations(Vestavia Hills, Palo Alto, Kansas City)
128 participants
Genentech, Inc.
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RecruitingNCT06260163

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis

The purpose of this study is to evaluate the efficacy of guselkumab in pediatric participants with moderately to severely active ulcerative colitis at the end of maintenance therapy among participants...

10 locations(Oakland, Indianapolis, Lake Success)
120 participants
Janssen Research & Development, LLC
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RecruitingNCT04624230

Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis

This study, A3921210 is designed to evaluate the efficacy, safety and pharmacokinetics (PK) of tofacitinib in pediatric participants with moderately to severely active UC. In the US and EU, patients w...

10 locations(Los Angeles, San Francisco, San Francisco)
120 participants
Pfizer
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RecruitingNCT05076175

A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis

The purpose of this study is to evaluate the effectiveness and safety of ozanimod (RPC1063) in achieving and maintaining clinical remission. Ozanimod will be administered orally to pediatric participa...

10 locations(Phoenix, Tucson, Garden Grove)
120 participants
Bristol-Myers Squibb
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RecruitingNCT03847467

Pilot and Feasibility Study of 2'-FL as a Dietary Supplement in IBD Patients Receiving Stable Maintenance Anti-TNF Therapy

Randomized, placebo-controlled dose-ranging study of 2'-FL in IBD, Crohn's Disease (CD) and ulcerative colitis (UC). The overarching hypothesis is that 2'-FL supplementation in IBD will be safe and we...

3 locations(Hartford, Cincinnati, Columbus)
116 participants
Children's Hospital Medical Center, Cincinnati
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RecruitingNCT05782907

Study to Assess Adverse Events, Change in Disease Activity, and How Oral Upadacitinib Moves Through the Body of Pediatric Participants With Moderately to Severely Active Ulcerative Colitis.

Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine). This study will assess how safe and eff...

10 locations(Phoenix, Little Rock, Corona)
110 participants
AbbVie
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RecruitingNCT06449352

Effect of Netarsudil vs Brimonidine in NTG Patients on Latanoprost

A randomized, multicenter, investigator-masked prospective study of NTG patients currently on latanoprost 0.005% monotherapy, to study the effect of IOP change with the introduction of netarsudil 0.02...

4 locations(Austin, Killeen, Kyle)
100 participants
Westlake Eye Specialists
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RecruitingNCT05011149

Selective Early Medical Treatment of Patent Ductus Arteriosus in Extremely Low Gestational Age Infants: A Pilot RCT

Background: Among preterm infants, those born at a gestational age less than 26 weeks are considered the most vulnerable with a high risk of short- and long-term health problems that include chronic l...

9 locations(Orange, San Diego, Oklahoma City)
100 participants
IWK Health Centre
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RecruitingNCT05111574

Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery

This phase II trial tests whether nivolumab in combination with cabozantinib works in patients with mucosal melanoma. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's i...

10 locations(Auburn, Berkeley, Fremont)
99 participants
National Cancer Institute (NCI)
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RecruitingNCT06975722

A Study to Investigate the Efficacy and Safety of SAR442970 in Adult Participants With Ulcerative Colitis

This is a phase 2b, randomized, double-blind, 3-arm study for the treatment of Ulcerative Colitis. The primary objective of this study is to assess the efficacy of different doses of SAR442970 compare...

10 locations(Escondido, Lancaster, Thousand Oaks)
99 participants
Sanofi
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RecruitingNCT04499248

AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension

This is a multicenter, open-label, dose escalation (Cohort 1) to masked, randomized, parallel-groups (Cohort 2) and (Cohort 3) study to evaluate the safety and efficacy of AGN-193408 SR in participant...

10 locations(Sun City, Glendale, Inglewood)
96 participants
AbbVie
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RecruitingNCT07113522

A Phase 2 Study to Evaluate Therapies for Inflammatory Bowel Disease

This is a Phase 2, multicenter, platform study in adult participants with IBD (moderately to severely active Crohn's Disease or Ulcerative Colitis). The primary goal of this study is to assess the saf...

10 locations(Little Rock, Miami, Orlando)
90 participants
Mirador Therapeutics, Inc.
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RecruitingNCT05344274

Retinal Blood Flow and Autoregulation

The purpose of this study is to establish autoregulation of retinal blood flow in arterioles and capillaries as a biomarker for early primary open angle glaucoma....

4 locations(Baltimore, Baltimore, Baltimore)
90 participants
University of Maryland, Baltimore
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RecruitingNCT05731128

A Study to Investigate the Efficacy and Safety of Dupilumab Therapy Compared With Placebo in Participants Aged ≥18 Years With Moderately to Severely Active Ulcerative Colitis With an Eosinophilic Phenotype (LIBERTY-UC SUCCEED (Study in UC for Clinical Efficacy Evaluation of Dupilumab))

The protocol of this Phase 2 clinical trial consists of a double-blind, placebo-controlled, parallel-group, multicenter study to evaluate the efficacy and safety of dupilumab in participants with mode...

10 locations(Apple Valley, Beverly Hills, Camarillo)
84 participants
Sanofi
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RecruitingNCT05874414

Combination of GNS561 and Trametinib in Patients With Advanced KRAS Mutated Cholangiocarcinoma

This is an open-label, multicenter Phase 1b/2a study to evaluate safety, pharmacokinetics (PK), pharmacodynamics (PD) and efficacy of GNS561 in combination with trametinib in Advanced KRAS Mutated Cho...

9 locations(Los Angeles, Los Angeles, Chicago)
74 participants
Genfit
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RecruitingNCT06100289

A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease

The main aim of this study is to learn how the body of a child or teenager with moderately to severely active ulcerative colitis (UC) or Crohn's disease (CD) processes vedolizumab (pharmacokinetics) g...

10 locations(Garden Grove, Loma Linda, Orange)
70 participants
Takeda
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RecruitingNCT04314375

Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Extended-release Tablets in Pediatric Subjects Aged 5 to 17 Years With Active, Mild to Moderate Ulcerative Colitis

This is a randomized, double-blind, placebo-controlled, multicenter, study to evaluate the efficacy, safety, and pharmacokinetics (PK) of budesonide extended-release tablets for the induction of remis...

4 locations(Garden Grove, Indianapolis, The Bronx)
70 participants
Bausch Health Americas, Inc.
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RecruitingNCT05693142

AFFINITY DUCHENNE: RGX-202 Gene Therapy in Participants With Duchenne Muscular Dystrophy (DMD)

RGX-202 is a gene therapy designed to deliver a transgene for a novel microdystrophin that includes functional elements of naturally-occurring dystrophin including the C-Terminal (CT) domain. This is...

10 locations(Little Rock, Palo Alto, Aurora)
65 participants
REGENXBIO Inc.
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RecruitingNCT06095128

A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)

The main aim of this study is to learn about the effect of treatment with vedolizumab IV (vedolizumab) together with tofacitinib in adults with moderate and severe ulcerative colitis (UC). Another aim...

10 locations(Dothan, Sun City, Los Angeles)
65 participants
Takeda
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RecruitingNCT05411198

Study to Assess Change in Disease Activity and Adverse Events of Ab Externo Approach for Glaucoma Gel Stent (XEN45) Implantation In Participants Aged 45 Years or Older With Open-Angle Glaucoma

Glaucoma is the second most common cause of blindness in the world, second only to cataracts. This study will assess how safe and effective a glaucoma gel stent is when implanted using the ab externo ...

10 locations(Fayetteville, Pasadena, Ventura)
65 participants
AbbVie
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RecruitingNCT05785819

A Phase 2 Study of VLX-1005 Versus Placebo in Suspected Heparin Induced Thrombocytopenia

The purpose of this study is to evaluate the efficacy and safety of VLX-1005, a 12-lipoxygenase (12-LOX) enzyme inhibitor in treating heparin induced thrombocytopenia (HIT). Participants with suspecte...

10 locations(Stanford, Aurora, New Haven)
60 participants
Veralox Therapeutics
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RecruitingNCT05275972

Descemet Endothelial Thickness Comparison Trial II

Descemet Endothelial Thickness Comparison Trial (DETECT) II is a multi-center, outcome assessor-masked, placebo-controlled clinical trial randomizing 60 patients with Fuchs endothelial dystrophy to DM...

7 locations(Palo Alto, Sacramento, Palm Beach Gardens)
60 participants
Stanford University
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RecruitingNCT05784246

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Moderately to Severely or Active Ulcerative Colitis

The main purpose of this study is to investigate efficacy, pharmacokinetics and safety of the drug in pediatric participants with moderately to severely active ulcerative colitis (UC)....

10 locations(Palo Alto, San Diego, San Francisco)
60 participants
Eli Lilly and Company
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RecruitingNCT06450639

A Study to Assess the Efficacy and Safety of Satralizumab in Duchenne Muscular Dystrophy (DMD)

The purpose of this study is to assess the efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of satralizumab, a humanized anti-interleukin-6 receptor (aIL-6R) monoclonal antibody, in a...

10 locations(Little Rock, Atlanta, Worcester)
50 participants
Hoffmann-La Roche
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RecruitingNCT06223048

A Study of AMDX-2011P in Participants With Primary Open Angle Glaucoma

The purpose of this research study is to assess the ability of AMDX- 2011P to identify amyloid deposits in the retina of participants with Primary Open Angle Glaucoma (POAG)....

3 locations(Phoenix, Glendale, Newport Beach)
50 participants
Amydis Inc.
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RecruitingNCT06109441

Efficacy/Safety of ALTB-268 in Subjects w/Moderately to Severely Active UC Refractory to Biologics

ALTB-268-201 is a Phase 2a, multicenter, single arm, multiple-dose, open-label study evaluating the efficacy and safety of ALTB-268 in subjects with moderately to severely active UC. The study consist...

10 locations(San Diego, Littleton, Miami)
50 participants
AltruBio Inc.
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RecruitingNCT02583672

Role of Oxidative Stress and Inflammation in Type 1 Gaucher Disease (GD1)

The purpose of this study is to measure levels of blood and brain chemicals related to oxidative stress and inflammation in healthy volunteers and individuals with Type 1 Gaucher disease (GD1) to see ...

2 locations(Minneapolis, New York)
50 participants
University of Minnesota
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RecruitingNCT04305145

Infliximab for Treatment of Immune Checkpoint Inhibitor Colitis

The goal of this clinical trial is to compare the safety and effectiveness of infliximab compared to steroids for the treatment of immune checkpoint inhibitor-induced colitis (ICI colitis) in patients...

2 locations(Boston, Boston)
42 participants
Massachusetts General Hospital
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RecruitingNCT06636656

A Study to Test Whether BI 3032950 Helps People With Ulcerative Colitis

Adults between 18 and 80 years of age with ulcerative colitis can participate in this study. This is a study for people for whom previous treatment was not successful or who stopped previous treatment...

10 locations(Scottsdale, Colorado Springs, New Haven)
40 participants
Boehringer Ingelheim
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RecruitingNCT06785454

A Study to Assess the Efficacy and Safety of Lorundrostat in Participants With Obstructive Sleep Apnea and Hypertension

The primary purpose of the study is to assess the effect of lorundrostat taken orally (po) once a day on the Apnea-Hypopnea Index (AHI) in participants with moderate to severe obstructive sleep apnea ...

10 locations(Tuscaloosa, Chandler, Little Rock)
40 participants
Mineralys Therapeutics Inc.
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RecruitingNCT06138639

A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)

This is a multicenter, open-label, non-randomized study to investigate the safety, tolerability, and efficacy of a single intravenous (IV) infusion of SGT-003 in participants with Duchenne muscular dy...

10 locations(Little Rock, Los Angeles, Sacramento)
40 participants
Solid Biosciences Inc.
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RecruitingNCT06315738

Study to Assess the Safety, Tolerability, and Preliminary Efficacy of ST266 in Infants With Necrotizing Enterocolitis

The primary objective of this study is to determine the safety and tolerability of two dose levels (0.5 mL/kg and 1.0 mL/kg) of once daily (QD) via IV route of administration of ST266 in treating pati...

7 locations(New Haven, Orlando, Tampa)
36 participants
Noveome Biotherapeutics, formerly Stemnion
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RecruitingNCT05287126

A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis

The purpose of this study is to determine the safety, efficacy, and pharmacokinetics (PK) of etrasimod for the treatment of moderately to severely active ulcerative colitis in adolescents (≥ 12 years ...

10 locations(Little Rock, Little Rock, Garden Grove)
36 participants
Pfizer
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RecruitingNCT06835387

Study of NALIRIFOX in Advanced Unresectable Small Bowel Tumors

The study regimen will be administered on an outpatient basis and all medications are administered intravenously (IV). Subjects will receive treatment on Day 1 and Day 15 of each 28-day cycle consisti...

4 locations(Tampa, Chicago, St Louis)
36 participants
Tiago Biachi de Castria
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RecruitingNCT06973785

Non-Narcotic Pain Control After ACL Reconstruction

This is a double-blind randomized controlled trial of standard of care therapy, either oral ketorolac (experimental group) or oral oxycodone (control group) to demonstrate efficacy in reducing the per...

3 locations(Coral Springs, Garfield, Strongsville)
30 participants
The Cleveland Clinic
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RecruitingNCT07024693

DT-168 in Keratoplasty Patients With Fuchs Endothelial Corneal Dystrophy

The purpose of this study is to evaluate the pharmacodynamics, safety, and tolerability of DT-168 Ophthalmic Solution in pre-keratoplasty patients with Fuchs endothelial corneal dystrophy....

2 locations(Indianapolis, Grand Rapids)
28 participants
Design Therapeutics, Inc.
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RecruitingNCT05412394

Once Weekly Infant Corticosteroid Trial for DMD

The hypothesis tested here is that a lower dose of intermittent oral corticosteroids (5mg/kg/week) will be equally effective to the 10mg/kg/week dose....

4 locations(Chicago, Cincinnati, Columbus)
26 participants
Anne M. Connolly
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RecruitingNCT06864403

Mirikizumab in the Treatment of Chronic Inflammatory Conditions of the Pouch

The goal of this clinical trial is to learn if mirikizumab works to treat pouch disorders in adults. The main questions it aims to answer are: Does mirikizumab reduce symptoms of pouch disorders Par...

4 locations(Rochester, New York, Chapel Hill)
25 participants
University of North Carolina, Chapel Hill
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RecruitingNCT05996003

NS-089/NCNP-02-201 in Boys With Duchenne Muscular Dystrophy (DMD)

This is a Phase 2, open-label, multi-center, 2-part study of NS-089/NCNP-02 administered by weekly IV infusion to ambulant boys aged ≥4 to \<15 years with DMD due to mutations amenable to exon 44 skip...

10 locations(Aurora, Kissimmee, Atlanta)
20 participants
NS Pharma, Inc.
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RecruitingNCT05642455

SPEARHEAD-3 Pediatric Study

This is a pediatric basket study to investigate the safety and efficacy of afamitresgene autoleucel in HLA-A\*02 eligible and MAGE-A4 positive subjects aged 2-17 years of age with advanced cancers....

10 locations(Palo Alto, Bethesda, Boston)
20 participants
Adaptimmune
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RecruitingNCT06053814

NS-050/NCNP-03 in Boys With DMD (Meteor50)

This is a Phase 1/2 study of Multiple-Ascending Dose (MAD) levels for 12 weeks of treatment followed by 24 weeks of open-label treatment with a selected dose of NS-050/NCNP-03 administered once weekly...

10 locations(Los Angeles, Aurora, Chicago)
20 participants
NS Pharma, Inc.
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RecruitingNCT05384496

Axitinib and Nivolumab for the Treatment of Mucosal Melanoma

The researchers are doing this study to find out whether the combination of axitinib and nivolumab is an effective and safe treatment for people with advanced or metastatic mucosal melanoma that has n...

2 locations(Harrison, New York)
20 participants
Memorial Sloan Kettering Cancer Center
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RecruitingNCT06312683

Rifaximin for the Secondary Prevention of Recurrent Pouchitis

Although many people will develop recurrent pouchitis (inflammation of the ileal pouch-anal anastomosis or J-pouch after colectomy for ulcerative colitis) after an initial episode of pouchitis, there ...

2 locations(New York, Chapel Hill)
16 participants
University of North Carolina, Chapel Hill
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RecruitingNCT05487599

A Clinical Trial of PR001 (LY3884961) in Patients With Peripheral Manifestations of Gaucher Disease (PROCEED)

Study J3Z-MC-OJAE is a Phase 1/2, multicenter, open-label, dose-finding study of LY3884961 evaluating the safety and tolerability in adults with peripheral manifestations of GD. Up to 3 dose levels o...

8 locations(Chicago, Durham, Fairfax)
15 participants
Prevail Therapeutics
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Top Cities for Ulcerative Colitis Clinical Trials

Ulcerative Colitis clinical trials are recruiting across 233 cities. Here are the cities with the most active studies:

About Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory bowel disease that causes inflammation and ulcers in the innermost lining of the colon and rectum. It typically presents with bloody diarrhea, abdominal pain, and urgency. Treatment includes aminosalicylates, corticosteroids, immunosuppressants, and biologics.

Clinical trials are advancing new treatments for ulcerative colitis. Currently, 75 studies are recruiting a combined 15,391 participants across the United States. Research is being conducted by 50 organizations including Merck Sharp & Dohme LLC, Eli Lilly and Company, Yale University and 47 others.

2026 Ulcerative Colitis Research Landscape

As of March 2026, the ulcerative colitis clinical trial landscape includes 75 actively recruiting studies across 233 cities in the United States. These studies are collectively seeking 15,391 participants, with an average enrollment target of 205 per study.

Research is being led by 50 different organizations, including Merck Sharp & Dohme LLC, Eli Lilly and Company, Yale University, AbbVie, Spyre Therapeutics, Inc., and 45 others. The large number of sponsors reflects significant research interest and investment in ulcerative colitis treatment advancement.

Geographically, ulcerative colitis trials are most concentrated in New York, New York (17 trials); Atlanta, Georgia (16 trials); Miami, Florida (15 trials); Lancaster, California (14 trials); Los Angeles, California (13 trials) and 7 other cities.

Featured Ulcerative Colitis Studies

Highlighted recruiting studies for ulcerative colitis, selected by enrollment size and research scope.

RecruitingNCT06651281

Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)

Researchers want to learn more about tulisokibart (also known as MK-7240) in an extension study. Tulisokibart is a medicine designed to treat active, moderate to severe Crohn's disease (CD) and ulcerative colitis (UC). An extension study is a type of study where people who received tulisokibart in certain other studies for CD or UC (called a parent study) may be able to join this study. The goals ...

Sponsor: Merck Sharp & Dohme LLC· 1,380 participants· 10 locations (Bristol, Ypsilanti, Liberty, New York)
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RecruitingNCT03519945

A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)

This study is designed to evaluate the long-term efficacy and safety of mirikizumab in participants with moderately to severely active ulcerative colitis (UC). The study will last up to 3 years. Participants who complete the 3-year study may continue to receive mirikizumab until it is (outside of this study) in their country or until they meet other discontinuation criteria.

Sponsor: Eli Lilly and Company· 1,063 participants· 10 locations (Dothan, Litchfield Park, Phoenix, Arcadia)
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RecruitingNCT06052059

A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)

The purpose of this protocol is to evaluate the efficacy of tulisokibart in participants with moderately to severely active ulcerative colitis. Study 1's primary hypotheses are that at least 1 tulisokibart dose level is superior to Placebo in the proportion of participants achieving clinical remission according to the Modified Mayo Score at Week 12, and that at least 1 tulisokibart dose level is s...

Sponsor: Merck Sharp & Dohme LLC· 1,020 participants· 10 locations (Dothan, Fairhope, Litchfield Park, Scottsdale)
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Frequently Asked Questions About Ulcerative Colitis Clinical Trials

Are there ulcerative colitis clinical trials near me?

Yes, there are 75 ulcerative colitis clinical trials currently recruiting across 233+ cities in the United States, including New York, New York; Atlanta, Georgia; Miami, Florida. Browse the studies above to find one at a location convenient for you.

How do I join a ulcerative colitis clinical trial?

To join a ulcerative colitis clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.

Are ulcerative colitis clinical trials free?

Yes, participation in ulcerative colitis clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.

What types of ulcerative colitis treatments are being studied?

Current ulcerative colitis clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 50 research organizations.

Is it safe to participate in ulcerative colitis clinical trials?

Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.

Data updated March 1, 2026 from ClinicalTrials.gov

About This Data

Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.

Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.

Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov