Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Scleroderma Clinical Trials
Scleroderma clinical trials are recruiting across 59 cities. Here are the cities with the most active studies:
About Scleroderma
Scleroderma is an autoimmune connective tissue disease characterized by hardening and tightening of the skin and connective tissues. Systemic sclerosis can also affect internal organs including lungs, kidneys, and heart. Treatment is directed at specific symptoms and organ involvement.
Clinical trials are advancing new treatments for scleroderma. Currently, 26 studies are recruiting a combined 3,120 participants across the United States. Research is being conducted by 22 organizations including University of Texas Southwestern Medical Center, Scleroderma Research Foundation, Inc., GlaxoSmithKline and 19 others.
2026 Scleroderma Research Landscape
As of July 2026, the scleroderma clinical trial landscape includes 26 actively recruiting studies across 59 cities in the United States. These studies are collectively seeking 3,120 participants, with an average enrollment target of 120 per study.
Research is being led by 22 different organizations, including University of Texas Southwestern Medical Center, Scleroderma Research Foundation, Inc., GlaxoSmithKline, Hospital for Special Surgery, New York, Nkarta, Inc., and 17 others. The large number of sponsors reflects significant research interest and investment in scleroderma treatment advancement.
Geographically, scleroderma trials are most concentrated in Ann Arbor, Michigan (12 trials); Chicago, Illinois (10 trials); Los Angeles, California (6 trials); Boston, Massachusetts (5 trials); New York, New York (5 trials) and 7 other cities.
Featured Scleroderma Studies
Highlighted recruiting studies for scleroderma, selected by enrollment size and research scope.
Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository
The Morphea in Adults and Children (MAC) cohort is the first registry for both children and adults with morphea (also known as localized scleroderma) in the country. The purpose of the registry is to learn more about morphea, specifically: * How morphea behaves over time * How frequently specific problems occur along with morphea (for example, arthritis) * Whether morphea has an autoimmune backgr...
Platform Clinical Study for Conquering Scleroderma
The goal of this clinical trial is to test efficacy of different investigational products (IPs) compared with placebo on the change from baseline to the end of the treatment period at Week 52 in lung capacity in participants with Interstitial Lung Disease Secondary to Systemic Sclerosis.
A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease
This study investigates the efficacy and safety of belimumab compared to placebo, in addition to standard therapy, for the treatment of participants with systemic sclerosis associated interstitial lung disease (SSc-ILD). The study will evaluate the effect of belimumab treatment on lung function as well as on extra-pulmonary disease manifestations, including skin thickening and general symptoms, su...
Frequently Asked Questions About Scleroderma Clinical Trials
Are there scleroderma clinical trials near me?
Yes, there are 26 scleroderma clinical trials currently recruiting across 59+ cities in the United States, including Ann Arbor, Michigan; Chicago, Illinois; Los Angeles, California. Browse the studies above to find one at a location convenient for you.
How do I join a scleroderma clinical trial?
To join a scleroderma clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are scleroderma clinical trials free?
Yes, participation in scleroderma clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of scleroderma treatments are being studied?
Current scleroderma clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 22 research organizations.
Is it safe to participate in scleroderma clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 13, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 13, 2026 · Data from ClinicalTrials.gov