NCT06220721 · Medical College of Wisconsin
Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia
(REPAIR)
What this study is about
The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfunction generated by hypertensive disorders of pregnancy, thus attenuating the lifelong trajectory of cardiovascular disease risk.
View original scientific description
The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfunction generated by hypertensive disorders of pregnancy, thus attenuating the lifelong trajectory of cardiovascular disease risk.
Interventions
DRUG
Nifedipine ER
Initiation of nifedipine ER postpartum at randomly assigned threshold during the first 6 weeks postpartum.
Primary outcome measures
Chronic hypertension
Time frame: One year postpartum
Diagnosis of chronic hypertension, defined as stage I hypertension with BP \>130/80 mmHg
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Hypertensive disorders of pregnancy (HDP) diagnosis, specifically gestational hypertension, preeclampsia, eclampsia, or HELLP syndrome, according to ACOG guidelines
- Postpartum day 0-4
- Age ≥ 18 years
- Able to communicate in English or in Spanish
- Has an established OBGYN at an MCW or NU health system practice that has access to Epic electronic medical records.
Exclusion criteria
- Pre-gestational hypertension
- Type 1 or type 2 diabetes mellitus
- Admitted to intensive care unit at the time of screening
- Diagnosed with HDP during postpartum readmission after discharge from delivery hospitalization
- Getting discharged on the day of screening
- Known allergy or contraindication to nifedipine ER
- Inability or unwillingness to provide informed consent
- Already taking long-acting antihypertensive medication for standard care
- Maternal conditions that impact study outcomes: sickle cell disease, systemic lupus erythematosus
Where
- Chicago, Illinois
- Milwaukee, Wisconsin
Collaborators
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced May 11, 2025 · Source of record for eligibility and locations