12 Brain Cancer Clinical Trials in Cincinnati, OH (2026)

Q: How do I join a clinical trial in Cincinnati?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Cincinnati research site will contact you.

Recruiting Brain Cancer Studies in Cincinnati

NCT03101813Recruiting

International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository

Doctors and other medical scientists want learn about the biology of DIPG/DMG and to develop better ways to diagnose and treat patients with DIPG/DMG. To do this, they need more information about the ...

Cincinnati, OH1,500 participantsChildren's Hospital Medical Center, Cincinnati

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NCT05839379Recruiting

Targeted Pediatric High-Grade Glioma Therapy

The goal of this study is to perform genetic sequencing on brain tumors from children, adolescents, and young adult patients who have been newly diagnosed with a high-grade glioma. This molecular prof...

Cincinnati, OH350 participantsNationwide Children's Hospital

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NCT05096481Recruiting

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

This study will address the question of whether targeting CMV antigens with PEP-CMV can serve as a novel immunotherapeutic approach in pediatric patients with newly-diagnosed high-grade glioma (HGG) o...

Cincinnati, OHPHASE2120 participantsNationwide Children's Hospital

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NCT05843253Recruiting

Study of Ribociclib and Everolimus in HGG and DIPG

The goal of this study is to determine the efficacy of the study drugs ribociclib and everolimus to treat pediatric and young adult patients newly diagnosed with a high-grade glioma (HGG), including D...

Cincinnati, OHPHASE2120 participantsNationwide Children's Hospital

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NCT07321353Recruiting

Survivors Journey+

The main goal of this pilot randomized controlled trial is to learn if an online program called "Survivors Journey" (SJ+) can help teens and young adults, ages 15-25, who are Pediatric Brain Tumor Sur...

Cincinnati, OHNA72 participantsChildren's Hospital Medical Center, Cincinnati

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NCT05278208Recruiting

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

This study will evaluate the safety and efficacy of Lutathera (177Lu-DOTATATE) in patients with progressive or recurrent High-Grade Central Nervous System (CNS) tumors and meningiomas that demonstrate...

Cincinnati, OHPHASE165 participantsNationwide Children's Hospital

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NCT06161974Recruiting

Study of Olutasidenib and Temozolomide in HGG

The goal of this study is to determine the efficacy of the study drug olutasidenib to treat newly diagnosed pediatric and young adult patients with a high-grade glioma (HGG) harboring an IDH1 mutation...

Cincinnati, OHPHASE260 participantsRigel Pharmaceuticals

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NCT06838676Recruiting

ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas

This is a Phase II open-label study to investigate the safety and efficacy of ACT001 in patients with DIPG and H3K27-altered HGG....

Cincinnati, OHPHASE260 participantsNationwide Children's Hospital

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NCT04774718Recruiting

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors

This study will evaluate the safety, pharmacokinetics, and efficacy of alectinib in children and adolescents with ALK fusion-positive solid or CNS tumors for whom prior treatment has proven to be inef...

Cincinnati, OHPHASE142 participantsHoffmann-La Roche

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NCT03122197Recruiting

Study of Letrozole in Recurrent Gliomas

The purpose of this study is to determine the ability of letrozole to penetrate the blood brain barrier and concentrate in gliomas....

Cincinnati, OHEARLY_PHASE139 participantsUniversity of Cincinnati

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NCT06333899Recruiting

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

The goal of this study is to determine the response of the study drug loratinib in treating children who are newly diagnosed high-grade glioma with a fusion in ALK or ROS1. It will also evaluate the s...

Cincinnati, OHEARLY_PHASE115 participantsNationwide Children's Hospital

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NCT04655404Recruiting

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

This is a pilot study that will evaluate disease status in children that have been newly diagnosed high-grade glioma with TRK fusion. The evaluation will occur after 2 cycles of the medication (Larotr...

Cincinnati, OHEARLY_PHASE115 participantsNationwide Children's Hospital

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About Brain Cancer Clinical Trials in Cincinnati

Brain cancer includes tumors that originate in the brain (primary) or spread from other areas (metastatic). Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Treatment typically combines surgery, radiation, and chemotherapy, with immunotherapy trials underway.

There are currently 12 brain cancer clinical trials recruiting participants in Cincinnati, OH. These studies are seeking a combined 2,458 participants. Research is being sponsored by Children's Hospital Medical Center, Cincinnati, Nationwide Children's Hospital, Rigel Pharmaceuticals and 2 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Brain Cancer Clinical Trials in Cincinnati — FAQ

Are there brain cancer clinical trials in Cincinnati?

Yes, there are 12 brain cancer clinical trials currently recruiting in Cincinnati, OH. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Cincinnati?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Cincinnati research site will contact you about next steps.

Are clinical trials in Cincinnati free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Cincinnati studies also compensate for your time and travel.

What brain cancer treatments are being tested?

The 12 active trials in Cincinnati are testing new therapies including novel drugs, biologics, and treatment approaches for brain cancer.

Data updated July 19, 2026 from ClinicalTrials.gov