12 Brain Cancer Clinical Trials in Cleveland, TX (2026)

Q: How do I join a clinical trial in Cleveland?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Cleveland research site will contact you.

Recruiting Brain Cancer Studies in Cleveland

NCT02977780Recruiting

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

This research study is studying several investigational drugs as a possible treatment for Glioblastoma (GBM). The drugs involved in this study are : * Abemaciclib * Temozolomide (temodar) * Neratini...

Cleveland, TX460 participantsPatrick Wen, MD

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NCT05124912Recruiting

REMASTer: REcurrent Brain Metastases After SRS Trial

Randomized, post-market multi-center study investigating the efficacy of two sets of treatment algorithms in brain metastases (BM) patients at the time of first intervention for radiographic progressi...

Cleveland, TX261 participantsMonteris Medical

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NCT07248228Recruiting

Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)

Participants in this research study have cancer that has spread to their brain, called brain metastases. One treatment for this type of cancer is called whole brain radiotherapy that stays away from a...

Cleveland, TX90 participantsCase Comprehensive Cancer Center

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NCT06101069Recruiting

Development of MRF for Characterization of Brain Tumors After Radiotherapy

The purpose of this study is to discover the potential convenience and ease of using a Magnetic Resonance Imaging (MRI) technique, named Magnetic Resonance Fingerprinting (or MRF), to achieve high-qua...

Cleveland, TX90 participantsCase Comprehensive Cancer Center

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NCT05879367Recruiting

Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma

The purpose of this study is to establish the recommended phase 2 dose of eflornithine in combination with temozolomide in patients whose glioblastoma or astrocytoma is newly diagnosed, and to evaluat...

Cleveland, TX66 participantsOrbus Therapeutics, Inc.

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NCT02704858Recruiting

Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma

This multi-site, Phase 1/2a clinical trial is an open-label study to identify the safety, pharmacokinetics, and efficacy of a repeated dose regimen of NEO100 (perillyl alcohol) for the treatment of pa...

Cleveland, TX49 participantsNeonc Technologies, Inc.

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NCT07003542Recruiting

A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas

The purpose of this study is to evaluate whether treating glioblastoma patients with sitagliptin can improve immune response against the tumor by targeting specific immune cells called myeloid-derived...

Cleveland, TX48 participantsCase Comprehensive Cancer Center

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NCT01891318Recruiting

Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study

This Phase I/II trial studies the ability to stop brain metastases from coming back after treatment with radiosurgery followed by surgical resection. It will also evaluate the side effects of these co...

Cleveland, TX36 participantsCase Comprehensive Cancer Center

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NCT04559230Recruiting

Sacituzumab Govitecan in Recurrent Glioblastoma

This is an open-label single arm study. All patients will receive the study drug. The aim of the study is to compare overall survival (OS) of patients with recurrent brain tumor, known as Glioblastoma...

Cleveland, TX32 participantsThe University of Texas Health Science Center at San Antonio

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NCT05607407Recruiting

Methimazole in Patients With Progressive Glioblastoma

The purpose of this study is to test the effectiveness, safety, and tolerability of a drug called Methimazole. The investigational drug, Methimazole is not FDA approved for brain tumors, but it is use...

Cleveland, TX19 participantsCase Comprehensive Cancer Center

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NCT05052957Recruiting

hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM)

This phase II trial studies the effect of P140K MGMT hematopoietic stem cells, O6-benzylguanine, temozolomide, and carmustine in treating participants with supratentorial glioblastoma or gliosarcoma w...

Cleveland, TX16 participantsLeland Metheny

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NCT05565118Recruiting

Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression

The purpose of this study is to test the safety and feasibility of recording brain activity within and around high-grade glioma tumors at the time of surgery. A small biopsy will be taken at the sites...

Cleveland, TX10 participantsCase Comprehensive Cancer Center

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About Brain Cancer Clinical Trials in Cleveland

Brain cancer includes tumors that originate in the brain (primary) or spread from other areas (metastatic). Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Treatment typically combines surgery, radiation, and chemotherapy, with immunotherapy trials underway.

There are currently 12 brain cancer clinical trials recruiting participants in Cleveland, TX. These studies are seeking a combined 1,177 participants. Research is being sponsored by Patrick Wen, MD, Monteris Medical, Case Comprehensive Cancer Center and 4 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Brain Cancer Clinical Trials in Cleveland — FAQ

Are there brain cancer clinical trials in Cleveland?

Yes, there are 12 brain cancer clinical trials currently recruiting in Cleveland, TX. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Cleveland?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Cleveland research site will contact you about next steps.

Are clinical trials in Cleveland free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Cleveland studies also compensate for your time and travel.

What brain cancer treatments are being tested?

The 12 active trials in Cleveland are testing new therapies including novel drugs, biologics, and treatment approaches for brain cancer.

Data updated July 13, 2026 from ClinicalTrials.gov