15 Brain Cancer Clinical Trials in Columbus, OH (2026)

Q: How do I join a clinical trial in Columbus?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Columbus research site will contact you.

Recruiting Brain Cancer Studies in Columbus

NCT05839379Recruiting

Targeted Pediatric High-Grade Glioma Therapy

The goal of this study is to perform genetic sequencing on brain tumors from children, adolescents, and young adult patients who have been newly diagnosed with a high-grade glioma. This molecular prof...

Columbus, OH350 participantsNationwide Children's Hospital

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NCT05843253Recruiting

Study of Ribociclib and Everolimus in HGG and DIPG

The goal of this study is to determine the efficacy of the study drugs ribociclib and everolimus to treat pediatric and young adult patients newly diagnosed with a high-grade glioma (HGG), including D...

Columbus, OHPHASE2120 participantsNationwide Children's Hospital

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NCT05096481Recruiting

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

This study will address the question of whether targeting CMV antigens with PEP-CMV can serve as a novel immunotherapeutic approach in pediatric patients with newly-diagnosed high-grade glioma (HGG) o...

Columbus, OHPHASE2120 participantsNationwide Children's Hospital

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NCT07225621Recruiting

Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

The purpose of this research is to test an investigational device using ultrasound along with an investigational drug to see if it is useful in treating glioblastoma following standard of care therapy...

Columbus, OHPHASE2103 participantsAlpheus Medical, Inc.

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NCT07680439Recruiting

Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG).

This study will evaluate BCB-276, an investigational B7-H3-targeted Chimeric Antigen Receptor (CAR) T cell therapy, in children and young adults with diffuse intrinsic pontine glioma (DIPG). DIPG is a...

Columbus, OHPHASE275 participantsBrainChild Bio, Inc

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NCT07321353Recruiting

Survivors Journey+

The main goal of this pilot randomized controlled trial is to learn if an online program called "Survivors Journey" (SJ+) can help teens and young adults, ages 15-25, who are Pediatric Brain Tumor Sur...

Columbus, OHNA72 participantsChildren's Hospital Medical Center, Cincinnati

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NCT07346144Recruiting

Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma

The goal of this clinical trial is to first define the Safety and Optimal Biological Dose (OBD) of study drug TGX-007 and to then further investigate the safety and efficacy in patients with newly dia...

Columbus, OHPHASE168 participantsTrogenix ltd

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NCT05278208Recruiting

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

This study will evaluate the safety and efficacy of Lutathera (177Lu-DOTATATE) in patients with progressive or recurrent High-Grade Central Nervous System (CNS) tumors and meningiomas that demonstrate...

Columbus, OHPHASE165 participantsNationwide Children's Hospital

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NCT06838676Recruiting

ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas

This is a Phase II open-label study to investigate the safety and efficacy of ACT001 in patients with DIPG and H3K27-altered HGG....

Columbus, OHPHASE260 participantsNationwide Children's Hospital

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NCT06161974Recruiting

Study of Olutasidenib and Temozolomide in HGG

The goal of this study is to determine the efficacy of the study drug olutasidenib to treat newly diagnosed pediatric and young adult patients with a high-grade glioma (HGG) harboring an IDH1 mutation...

Columbus, OHPHASE260 participantsRigel Pharmaceuticals

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NCT06964737Recruiting

Anti-GARP Chimeric Antigen Receptor T Cell Therapy for the Treatment of Recurrent Grade III or IV Gliomas

This phase I trial tests the safety, side effects, and best dose of anti-glycoprotein-A repetitions predominant (GARP) chimeric antigen receptor (CAR) T cell therapy and how well it works in treating ...

Columbus, OHPHASE130 participantsOhio State University Comprehensive Cancer Center

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NCT04254419Recruiting

Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells

Each patient will receive up to 12 cycles of TGFβi NK cell infusions. Each cycle will be of 4 weeks duration. During the first 3 weeks, TGFβi NK cells will be infused once weekly. The 4th week will be...

Columbus, OHPHASE118 participantsNationwide Children's Hospital

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NCT06333899Recruiting

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

The goal of this study is to determine the response of the study drug loratinib in treating children who are newly diagnosed high-grade glioma with a fusion in ALK or ROS1. It will also evaluate the s...

Columbus, OHEARLY_PHASE115 participantsNationwide Children's Hospital

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NCT04655404Recruiting

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

This is a pilot study that will evaluate disease status in children that have been newly diagnosed high-grade glioma with TRK fusion. The evaluation will occur after 2 cycles of the medication (Larotr...

Columbus, OHEARLY_PHASE115 participantsNationwide Children's Hospital

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NCT06910306Recruiting

Alpha Radiation Emitters Device (DaRT) for the Treatment of Recurrent Glioblastoma

A unique approach for cancer treatment employing intratumoral diffusing alpha radiation emitter device for the treatment of recurrent Glioblastoma...

Columbus, OHNA10 participantsAlpha Tau Medical LTD.

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About Brain Cancer Clinical Trials in Columbus

Brain cancer includes tumors that originate in the brain (primary) or spread from other areas (metastatic). Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Treatment typically combines surgery, radiation, and chemotherapy, with immunotherapy trials underway.

There are currently 15 brain cancer clinical trials recruiting participants in Columbus, OH. These studies are seeking a combined 1,181 participants. Research is being sponsored by Nationwide Children's Hospital, Alpheus Medical, Inc., BrainChild Bio, Inc and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Brain Cancer Clinical Trials in Columbus — FAQ

Are there brain cancer clinical trials in Columbus?

Yes, there are 15 brain cancer clinical trials currently recruiting in Columbus, OH. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Columbus?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Columbus research site will contact you about next steps.

Are clinical trials in Columbus free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Columbus studies also compensate for your time and travel.

What brain cancer treatments are being tested?

The 15 active trials in Columbus are testing new therapies including novel drugs, biologics, and treatment approaches for brain cancer.

Data updated September 1, 2026 from ClinicalTrials.gov