8 Depression Clinical Trials in Denver, CO (2026)

Q: How do I join a clinical trial in Denver?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Denver research site will contact you.

Recruiting Depression Studies in Denver

NCT03388606Recruiting

Characterization and Treatment of Adolescent Depression

This research study seeks to find causes and treatments of depression in teenagers. The study goals are to increase our knowledge of treatments for depression and understand how the brain changes when...

Denver, CO4,100 participantsNational Institute of Mental Health (NIMH)

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NCT05766475Recruiting

In-person vs. Virtual Delivery of a Group-based Prevention of Postpartum Depression

The goal of this clinical trial is to test whether an established preventive intervention (group interpersonal therapy) delivered virtually shows the same benefits for preventing postpartum depression...

Denver, CONA900 participantsUniversity of Denver

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NCT05772897Recruiting

Parenting Skills Group for Mothers With Postpartum Depression

The goal of this longitudinal study is to study the effects of a parenting skills group (Circle of Security Parenting, aka COSP) in mothers with postpartum depression. The main questions it aims to an...

Denver, CONA750 participantsUniversity of Colorado, Denver

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NCT06564818Recruiting

"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"

The purpose of this study is to examine the efficacy, safety, and tolerability of CYB003 compared to matching placebo as adjunctive treatment in participants with MDD....

Denver, COPHASE3220 participantsCybin IRL Limited

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NCT07592689Recruiting

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Ascend...

Denver, COPHASE3165 participantsDefinium Therapeutics US, Inc.

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NCT06547489Recruiting

GATE-251 or Placebo for the Reduction of Symptoms of Major Depressive Disorder

The goal of this clinical trial is to learn if GATE-251 works to treat depression in adults. It will also learn about the safety of GATE-251. The main questions it aims to answer are: Does GATE-251 r...

Denver, COPHASE2164 participantsSyndeio Biosciences, Inc

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NCT07284667Recruiting

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

The goal of this clinical trial is to learn if ACP-211 can help treat adults with major depressive disorder (MDD) who have not improved with antidepressant therapy (ADT), including those with treatmen...

Denver, COPHASE2153 participantsACADIA Pharmaceuticals Inc.

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NCT06524830Recruiting

A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

This Phase 2 study (protocol number VLS-01-203) will determine the efficacy, safety, and tolerability of short-term treatment with a VLS-01 transmucosal buccal film (VLS-01-BU) in patients with treatm...

Denver, COPHASE2142 participantsatai Therapeutics, Inc.

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About Depression Clinical Trials in Denver

Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.

There are currently 8 depression clinical trials recruiting participants in Denver, CO. These studies are seeking a combined 6,594 participants. Research is being sponsored by National Institute of Mental Health (NIMH), University of Denver, University of Colorado, Denver and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Depression Clinical Trials in Denver — FAQ

Are there depression clinical trials in Denver?

Yes, there are 8 depression clinical trials currently recruiting in Denver, CO. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Denver?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Denver research site will contact you about next steps.

Are clinical trials in Denver free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Denver studies also compensate for your time and travel.

What depression treatments are being tested?

The 8 active trials in Denver are testing new therapies including novel drugs, biologics, and treatment approaches for depression.

Data updated July 22, 2026 from ClinicalTrials.gov