10 Brain Cancer Clinical Trials in Gainesville, FL (2026)

Q: How do I join a clinical trial in Gainesville?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Gainesville research site will contact you.

Recruiting Brain Cancer Studies in Gainesville

NCT05366881Recruiting

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers inc...

Gainesville, FL7,000 participantsAdela, Inc

View Study Details

NCT00811148Recruiting

Florida Center for Brain Tumor Research

The purpose of this research study is to collect and store brain tumor tissue samples for future research. The samples will become part of the University of Florida Brain Tumor Tissue Bank/Florida Cen...

Gainesville, FL4,000 participantsUniversity of Florida

View Study Details

NCT06556563Recruiting

EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

This is a multicenter, two-arm, randomized, double-blind, placebo-controlled study of Optune® (Tumor Treating Fields at 200 kHz) together with maintenance Temozolomide (TMZ) chemotherapy agent and pem...

Gainesville, FLPHASE3741 participantsNovoCure GmbH

View Study Details

NCT05303519Recruiting

Safusidenib Phase 2 Study in IDH1 Mutant Glioma

This is a 2-part study. The purpose of Part 1 of the study is to evaluate the efficacy, safety, and pharmacokinetic (PK) characteristics of safusidenib in participants with recurrent/progressive IDH1-...

Gainesville, FLPHASE3365 participantsNuvation Bio Inc.

View Study Details

NCT04485559Recruiting

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

This phase I trial studies the side effects and best dose of trametinib and everolimus in treating pediatric and young adult patients with gliomas that have come back (recurrent). Trametinib acts by t...

Gainesville, FLPHASE150 participantsUniversity of California, San Francisco

View Study Details

NCT05353530Recruiting

IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma

This is a phase I study to assess the safety and feasibility of IL-8 receptor modified patient-derived activated CD70 CAR T cell therapy in CD70+ adult glioblastoma...

Gainesville, FLPHASE139 participantsUniversity of Florida

View Study Details

NCT04573140Recruiting

A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)

The primary objective will be to demonstrate the manufacturing feasibility and safety, and to determine the maximum tolerated dose (MTD) of RNA-LP vaccines in (Stratum 1) adult patients with newly dia...

Gainesville, FLPHASE128 participantsUniversity of Florida

View Study Details

NCT06389591Recruiting

RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)

This is a Phase I study to demonstrate the manufacturing feasibility and safety, and to determine the maximum tolerated dose (MTD) of RNA-LP vaccines in adult patients with recurrent glioblastoma....

Gainesville, FLPHASE124 participantsUniversity of Florida

View Study Details

NCT06558214Recruiting

OPTIMUS PRIME: Safety and Feasibility of OPTune GIO® Integrated With MRI-gUided Laser Ablation Surgery and Pembrolizumab for Recurrent GlIoblastoMa, A randomizEd Trial

In this study we are evaluating the safety and feasibility of the triple combination (TTFields, MLA, pembrolizumab) in adult patients diagnosed with recurrent or progressive glioblastoma (GBM) WHO Gra...

Gainesville, FLPHASE220 participantsUniversity of Florida

View Study Details

NCT06254326Recruiting

ADAGiO: Adoptive Cellular Therapy for the TreAtment of Recurrent OliGodendrogliOma (OG) Adult Patients

This study will enroll 6 DLT evaluable subjects (up to 12 patients total) where we will evaluate feasibility and safety of adoptive cellular therapy combined with IDH1/2 inhibitors in patients with re...

Gainesville, FLPHASE112 participantsUniversity of Florida

View Study Details

About Brain Cancer Clinical Trials in Gainesville

Brain cancer includes tumors that originate in the brain (primary) or spread from other areas (metastatic). Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Treatment typically combines surgery, radiation, and chemotherapy, with immunotherapy trials underway.

There are currently 10 brain cancer clinical trials recruiting participants in Gainesville, FL. These studies are seeking a combined 12,279 participants. Research is being sponsored by Adela, Inc, University of Florida, NovoCure GmbH and 2 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Brain Cancer Clinical Trials in Gainesville — FAQ

Are there brain cancer clinical trials in Gainesville?

Yes, there are 10 brain cancer clinical trials currently recruiting in Gainesville, FL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Gainesville?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Gainesville research site will contact you about next steps.

Are clinical trials in Gainesville free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Gainesville studies also compensate for your time and travel.

What brain cancer treatments are being tested?

The 10 active trials in Gainesville are testing new therapies including novel drugs, biologics, and treatment approaches for brain cancer.

Data updated July 18, 2026 from ClinicalTrials.gov