9 Major Depressive Disorder Clinical Trials in Glendale, CA (2026)

Q: How do I join a clinical trial in Glendale?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Glendale research site will contact you.

Recruiting Major Depressive Disorder Studies in Glendale

NCT06966401Recruiting

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

This study will evaluate the long-term safety and tolerability of NBI-1065845 as an adjunctive treatment in participants with MDD....

Glendale, CAPHASE3850 participantsNeurocrine Biosciences

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NCT06559306Recruiting

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

The purpose of this study is to know how well seltorexant works, and also to evaluate safety and maintenance effect of seltorexant compared with placebo as an adjunctive therapy to an antidepressant i...

Glendale, CAPHASE3752 participantsJanssen Research & Development, LLC

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NCT07484217Recruiting

Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

CLARITY (Clinical Assessment of Response in the Treatment of Depression with Daytime Sleepiness Using Solriamfetol) is a Phase 3, double-blind, placebo-controlled, multicenter randomized withdrawal tr...

Glendale, CAPHASE3508 participantsAxsome Therapeutics, Inc.

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NCT07065240Recruiting

A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

This is a randomized, parallel-group, double-blind, placebo-controlled, monotherapy study to evaluate the efficacy, safety, and tolerability of SPT-300 (GlyphAllo) in adults with major depressive diso...

Glendale, CAPHASE2360 participantsSeaport Therapeutics

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NCT06793397Recruiting

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

The purpose of this study is to determine the efficacy, safety and tolerability of CYB003 compared to matching placebo as adjunctive treatment in patients with MDD....

Glendale, CAPHASE3330 participantsCybin IRL Limited

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NCT05922878Recruiting

Study of ALTO-300 in MDD

The purpose of this study is to determine efficacy differences between ALTO-300 and placebo, used adjunctively to an antidepressant, related to patient characteristics....

Glendale, CAPHASE2321 participantsAlto Neuroscience

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NCT06633016Recruiting

Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

The goal of this clinical trial is to learn if ABX-002 added to an existing antidepressant treatment will benefit depression symptoms in adults with moderate to severe major depressive disorder who ha...

Glendale, CAPHASE2230 participantsAutobahn Therapeutics, Inc.

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NCT06911112Recruiting

NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depression....

Glendale, CAPHASE3200 participantsNeurocrine Biosciences

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NCT07284667Recruiting

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

The goal of this clinical trial is to learn if ACP-211 can help treat adults with major depressive disorder (MDD) who have not improved with antidepressant therapy (ADT), including those with treatmen...

Glendale, CAPHASE2153 participantsACADIA Pharmaceuticals Inc.

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About Major Depressive Disorder Clinical Trials in Glendale

Major depressive disorder (MDD) is a severe form of depression characterized by persistent sadness, loss of interest, and impaired daily functioning. Treatment-resistant depression (TRD) affects patients who do not respond to standard therapies. Novel treatments like ketamine, psilocybin, and neuromodulation are being studied.

There are currently 9 major depressive disorder clinical trials recruiting participants in Glendale, CA. These studies are seeking a combined 3,704 participants. Research is being sponsored by Neurocrine Biosciences, Janssen Research & Development, LLC, Axsome Therapeutics, Inc. and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Major Depressive Disorder Clinical Trials in Glendale — FAQ

Are there major depressive disorder clinical trials in Glendale?

Yes, there are 9 major depressive disorder clinical trials currently recruiting in Glendale, CA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Glendale?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Glendale research site will contact you about next steps.

Are clinical trials in Glendale free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Glendale studies also compensate for your time and travel.

What major depressive disorder treatments are being tested?

The 9 active trials in Glendale are testing new therapies including novel drugs, biologics, and treatment approaches for major depressive disorder.

Data updated October 18, 2026 from ClinicalTrials.gov