13 Depression Clinical Trials in Houston, NC (2026)

Q: How do I join a clinical trial in Houston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Houston research site will contact you.

Recruiting Depression Studies in Houston

NCT06257095Recruiting

Improving Adult Protective Services Client Outcomes: A Stepped-Care Social and Mental Health Engagement Program

The purpose of this study is to ascertain the feasibility and effectiveness of an 8-week social engagement program aimed at reducing depression and increasing social engagement among seniors who are t...

Houston, NC400 participantsThe University of Texas Health Science Center, Houston

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NCT06864715Recruiting

Behavioral Activation for the PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors

The overall objective of the project is to determine the effectiveness of tele-delivered behavioral activation (BA) by trained lay counselors (Tele-BA-S) to prevent Post-stroke depression (PSD) in low...

Houston, NC350 participantsThe University of Texas Health Science Center, Houston

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NCT06273995Recruiting

Telehealth Behavioral Activation for Teens

Behavioral activation is one such empirically supported intervention. Derived from cognitive-behavioral therapy, a well-established treatment for depression, behavioral activation uses psychoeducation...

Houston, NC250 participantsBaylor College of Medicine

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NCT06923995Recruiting

Expansion and Evaluation of AI-generated Clinical Assessment (AI-COA®) of Depression and Anxiety Severity

The SEQUOIA-1 study evaluates the effectiveness of Artificial Intelligence (AI) in measuring depression and anxiety severity in adults. Investigators from Deliberate Solutions, Inc. and Baylor College...

Houston, NC120 participantsDeliberate Solutions Inc.

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NCT05418894Recruiting

Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing

The overall goal of this study is to map the spatiotemporal dynamics of social affective processing and to examine selective modulation of these dynamics in humans undergoing invasive intracranial mon...

Houston, NC84 participantsBaylor College of Medicine

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NCT05871372Recruiting

Intracranial Investigation of Neural Circuity Underlying Human Mood

Depression is one of the most common disorders of mental health, affecting 7-8% of the population and causing tremendous disability to afflicted individuals and economic burden to society. In order to...

Houston, NC58 participantsBaylor College of Medicine

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NCT06910267Recruiting

Leveraging Adult Protective Service Interaction to Offer Evidence-Based Treatment for Depression in Elder Neglect/Self Neglect

The purpose of this study is to test the feasibility and acceptability of an evidence-based treatment for depression delivered over an ipad, computer, or smartphone can help Adult Protective Services ...

Houston, NC50 participantsThe University of Texas Health Science Center, Houston

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NCT03522545Recruiting

Adjunctive Allogeneic Mesenchymal Stem Cells for Treatment-resistant Bipolar Depression

The overall objective of the investigators is to assess the therapeutic efficacy and tolerability of Allogeneic Bone Marrow Derived Multipotent Mesenchymal Stromal Cells (MSCs) isolated from hematogen...

Houston, NC30 participantsThe University of Texas Health Science Center, Houston

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NCT06200155Recruiting

Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy

To learn about the feasibility, safety, and effects of psilocybin-assisted psychotherapy on depression and/or anxiety in participants who are being treated for advanced cancer....

Houston, NC30 participantsM.D. Anderson Cancer Center

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NCT06801041Recruiting

TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors

This clinical research study is to learn about the feasibility, safety, and effects of psilocybin-assisted psychotherapy for cancer survivors with depression and/or anxiety....

Houston, NC20 participantsM.D. Anderson Cancer Center

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NCT06695767Recruiting

Neurobehavioral Therapy For Epilepsy And Major Depressive Disorder

The purpose of this study is to examine the feasibility and acceptability of an online group Neuro-behavioral Therapy (NBT) with text messaging intervention for Veterans with epilepsy and major depres...

Houston, NC16 participantsThe University of Texas Health Science Center, Houston

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NCT03437928Recruiting

DBS for Depression

The goal of the study is to address the unmet need of TRD patients by identifying brain networks critical for treating depression and to use next generation precision DBS with steering capability to e...

Houston, NC12 participantsBaylor College of Medicine

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NCT06599099Recruiting

Deep Brain Stimulation of Treatment-Resistant Bipolar Depression

This study is only enrolling at Baylor College of Medicine. The other research locations listed serve to support data analysis only. This research study is to investigate the use of technology called...

Houston, NC10 participantsWayne Goodman MD

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About Depression Clinical Trials in Houston

Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.

There are currently 13 depression clinical trials recruiting participants in Houston, NC. These studies are seeking a combined 1,430 participants. Research is being sponsored by The University of Texas Health Science Center, Houston, Baylor College of Medicine, Deliberate Solutions Inc. and 2 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Depression Clinical Trials in Houston — FAQ

Are there depression clinical trials in Houston?

Yes, there are 13 depression clinical trials currently recruiting in Houston, NC. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Houston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Houston research site will contact you about next steps.

Are clinical trials in Houston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Houston studies also compensate for your time and travel.

What depression treatments are being tested?

The 13 active trials in Houston are testing new therapies including novel drugs, biologics, and treatment approaches for depression.

Data updated July 13, 2026 from ClinicalTrials.gov