23 Sarcoma Clinical Trials in Houston, NC (2026)

Q: How do I join a clinical trial in Houston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Houston research site will contact you.

Recruiting Sarcoma Studies in Houston

NCT06797999Recruiting

First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma

The goal of this clinical trial is to learn about the safety, tolerability and efficacy of ADCE-D01....

Houston, NC270 participantsAdcendo ApS

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NCT04751409Recruiting

Evaluating the Impact of Limited Compared With Intense Post-Operative Surveillance on Patient-Reported Outcomes in Patients With Stage II-III Soft Tissue Sarcoma of the Trunk and Extremities

This phase II trial studies how anxiety is affected by 2 types of follow-up after surgery, limited follow-up and intense follow-up, in patients with stage II-III soft tissue sarcoma of the trunk and e...

Houston, NC227 participantsM.D. Anderson Cancer Center

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NCT05653388Recruiting

Metastatic Leiomyosarcoma Biomarker Protocol

Leiomyosarcoma (LMS) is one of the most prevalent soft tissue sarcomas (STS) and can occur in various sites including soft tissue, uterus and retroperitoneal large vessels. Metastatic disease occurs i...

Houston, NC200 participantsUniversity of Michigan Rogel Cancer Center

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NCT05054335Recruiting

Patient-Specific Computational Walking Models in Improving Surgical and Rehabilitation Treatment in Patients With Pelvic Sarcomas

This trial studies the development of patient-specific computational walking models to improve the surgical planning and rehabilitation treatment of patients with pelvic sarcomas. Every pelvis and pel...

Houston, NC130 participantsM.D. Anderson Cancer Center

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NCT07377747Recruiting

Prospective Study Evaluating the Treatment Outcomes for Localised Recurrent, Resectable Retroperitoneal Liposarcoma

The aim of the study is to collect prospective data on the treatment outcomes in patients with first localized, resectable recurrent retroperitoneal well-differentiated and/or dedifferentiated liposar...

Houston, NC100 participantsAustralia and New Zealand Sarcoma Association

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NCT07215611Recruiting

Financial Toxicity in Patients With Resected Soft Tissue and Bone Sarcomas

To learn about the financial stress patients undergoing surgery to treat orthopedic cancer experience because of the costs of cancer care, and to learn about the effects of financial stress on partici...

Houston, NC100 participantsM.D. Anderson Cancer Center

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NCT01659203Recruiting

Proton or Photon RT for Retroperitoneal Sarcomas

This research study is a Phase I clinical trial. Phase I clinical trials test the safety of an investigational intervention. Phase I studies also try to define the appropriate dose of the investigatio...

Houston, NC80 participantsMassachusetts General Hospital

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NCT06498648Recruiting

Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma

This phase I/II trial tests the side effects and best dose of abemaciclib when added to gemcitabine and compares the effectiveness of that treatment to the usual treatment of gemcitabine with docetaxe...

Houston, NC74 participantsNational Cancer Institute (NCI)

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NCT07193550Recruiting

A Phase 2 Trial of Zanzalintinib in Advanced/Metastatic Bone Sarcomas (ZAMBONE)

To study the treatment efficacy of zanzalintinib monotherapy in patients with advanced and/or metastatic bone sarcomas....

Houston, NC70 participantsM.D. Anderson Cancer Center

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NCT07049848Recruiting

SATURN-STS: Phase II Study of Neoadjuvant Atezolizumab With Doxorubicin, Concurrent Atezolizumab With Pre-operative Radiation Therapy and Adjuvant Atezolizumab in Patients With High-risk Surgically Resectable Extremity and Truncal Soft Tissue Sarcoma

The goal of this clinical research study is to look at the effectiveness of giving a combination of chemotherapy, immunotherapy, radiation therapy, and surgery to treat soft tissue sarcomas that can b...

Houston, NC50 participantsM.D. Anderson Cancer Center

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NCT06083883Recruiting

Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1

The goal of this clinical research study is to find a recommended dose of donated NK cells that can be given along with chemotherapy to patients with advanced cancers. The safety and effects of this t...

Houston, NC44 participantsM.D. Anderson Cancer Center

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NCT04305691Recruiting

Trial of Ixazomib for Kaposi Sarcoma

This phase II trial studies how well ixazomib works in treating patients with Kaposi sarcoma. Ixazomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth....

Houston, NC41 participantsAIDS Malignancy Consortium

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NCT05019703Recruiting

Atezolizumab and Cabozantinib for the Treatment of Adolescents and Young Adults With Recurrent or Metastatic Osteosarcoma, TACOS Study

This phase II trial studies the effect of atezolizumab and cabozantinib in treating adolescents and young adults with osteosarcoma that has come back (recurrent) or has spread to other places in the b...

Houston, NC40 participantsM.D. Anderson Cancer Center

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NCT05621668Recruiting

A First-In-Human Phase 1 Trial of T-Cell Membrane-Anchored Tumor Targeted Il12 (Attil12)- T-Cell Therapy in Subjects With Advanced/Metastatic Soft Tissue and Bone Sarcoma

To find a recommended dose of attIL2-T cell therapy that can be given to patients with soft tissue or bone sarcomas and to see if it can help to control the disease....

Houston, NC40 participantsM.D. Anderson Cancer Center

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NCT06474676Recruiting

T Cell Membrane-Anchored Tumor-Targeted IL12 -Modified TIL Cell Therapy (attIL12-TIL) for Advanced/Metastatic Soft Tissue and Bone Sarcoma Patients.

To find a recommended dose of attIL2-TIL cell therapy that can be given to participant with either relapsed or metastatic sarcomas (has come back or spread to other parts of the body, respectively). ...

Houston, NC40 participantsM.D. Anderson Cancer Center

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NCT05726383Recruiting

Iscador® P (Mistletoe) Immunotherapy for Recurrent Osteogenic Sarcoma

This will be a phase II, single arm study of osteosarcoma patients with fully resected pulmonary metastases. The MTD corresponds to the dosage recommendations of the manufacturer of Iscador® P which i...

Houston, NC32 participantsHackensack Meridian Health

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NCT07156565Recruiting

Actinium Therapy for Late-stage Aggressive Sarcomas

The goal of this clinical trial is to learn about the safety of drug \[Ac225\]RTX-2358 and the diagnostic imaging agent \[Cu64\]LNTH-1363S. Additionally Ratio Therapeutics will learn if \[Ac225\]RTX-2...

Houston, NC30 participantsRatio Therapeutics, Inc.

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NCT05333458Recruiting

Testing Atezolizumab With Selinexor in People ≥ 12 Years Old With Alveolar Soft Part Sarcoma, The AXIOM Trial

This phase II trial tests whether atezolizumab in combination with selinexor works to shrink tumors in patients with alveolar soft part sarcoma and whether the study drugs are better than the usual ap...

Houston, NC27 participantsNational Cancer Institute (NCI)

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NCT04995003Recruiting

HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma

The purpose of this study is to learn whether it is safe to give HER2-CAR T cells in combination with an immune checkpoint inhibitor drug (pembrolizumab or nivolumab), to learn what the side effects a...

Houston, NC25 participantsBaylor College of Medicine

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NCT04991870Recruiting

Phase I CB-NK-TGF-ßR2-/NR3C1- in rGBM

This phase I trial is to find out the best dose, possible benefits and/or side effects of engineered natural killer (NK) cells containing deleted TGF-betaR2 and NR3C1 (cord blood \[CB\]-NK-TGF-betaR2-...

Houston, NC25 participantsM.D. Anderson Cancer Center

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NCT04199026Recruiting

Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent Sarcoma

This early phase I trial studies the side effects of implanting and removing a microdevice in patients with sarcomas that have spread to other places in the body (metastatic) or have come back (recurr...

Houston, NC20 participantsM.D. Anderson Cancer Center

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NCT06308419Recruiting

A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions

To find a recommended dose of gemcitabine and nab-sirolimus that can be given in combination to participants with advanced leiomyosarcomas or soft-tissue sarcomas....

Houston, NC18 participantsM.D. Anderson Cancer Center

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NCT07007273Recruiting

Pembrolizumab for Advanced Cutaneous Sarcomas Not Including Angiosarcoma

This is a single arm, open-label phase II study to assess the efficacy of single agent pembrolizumab for the treatment of advanced cutaneous sarcomas. Adult patients ≥18 years old who have been diagno...

Houston, NC17 participantsH. Lee Moffitt Cancer Center and Research Institute

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About Sarcoma Clinical Trials in Houston

Sarcomas are rare cancers that arise in bone and soft tissues including muscle, fat, blood vessels, and connective tissue. There are more than 70 subtypes of sarcoma. Treatment usually involves surgery combined with radiation and/or chemotherapy.

There are currently 23 sarcoma clinical trials recruiting participants in Houston, NC. These studies are seeking a combined 1,700 participants. Research is being sponsored by Adcendo ApS, M.D. Anderson Cancer Center, University of Michigan Rogel Cancer Center and 8 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Sarcoma Clinical Trials in Houston — FAQ

Are there sarcoma clinical trials in Houston?

Yes, there are 23 sarcoma clinical trials currently recruiting in Houston, NC. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Houston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Houston research site will contact you about next steps.

Are clinical trials in Houston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Houston studies also compensate for your time and travel.

What sarcoma treatments are being tested?

The 23 active trials in Houston are testing new therapies including novel drugs, biologics, and treatment approaches for sarcoma.

Data updated July 13, 2026 from ClinicalTrials.gov