Houston, TX9 Active Studies

Esophageal Cancer Clinical Trials in Houston, TX

Find 9 actively recruiting esophageal cancer clinical trials in Houston, TX. Connect with local research sites and explore new treatment options.

9
Active Trials
7
Sponsors
1,549
Enrolling

Recruiting Esophageal Cancer Studies in Houston

NCT03948100Recruiting

Dyadic Yoga Intervention in Improving Physical Performance and Quality of Life in Patients With Stage I-IV Non-small Cell Lung or Esophageal Cancer Undergoing Radiotherapy and Their Caregivers

This trial studies how well dyadic yoga intervention works in improving physical performance and quality of life in patients with stage I-IV non-small cell lung or esophageal cancer undergoing radioth...

Houston, TXNA400 participantsM.D. Anderson Cancer Center
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NCT07290985Recruiting

AACR Adaptive Biomarker-Driven Organ Preservation Trial in Gastroesophageal Adenocarcinomas

This study will test a new personalized treatment approach for patients with stomach or esophageal cancer. It will take place in two stages and aims to find the best combination of chemotherapy, immun...

Houston, TXPHASE2242 participantsAmerican Association for Cancer Research
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NCT06445972Recruiting

Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)

This is a phase 1/2 multicenter, open-label umbrella platform study that will evaluate the safety and efficacy of sacituzumab tirumotecan (MK-2870) plus paclitaxel versus ramucirumab plus paclitaxel, ...

Houston, TXPHASE1210 participantsMerck Sharp & Dohme LLC
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NCT06435286Recruiting

Effectiveness and Performance of an Optical Biopsy Technology for Esophageal Cancer in Brazil and the United States

In a previous clinical trial in China and the United States (US), the investigators developed and validated a mobile, high-resolution microendoscope (mHRME) for screening and surveillance of esophagea...

Houston, TXPHASE2200 participantsBaylor College of Medicine
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NCT06469944Recruiting

Substudy 06C: A Study of Sacituzumab Tirumotecan (MK-2870) With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)

This is a phase 1/2, multicenter, open-label umbrella platform study that will evaluate the safety and tolerability of sacituzumab tirumotecan with pembrolizumab and fluoropyrimidine chemotherapy for ...

Houston, TXPHASE1160 participantsMerck Sharp & Dohme LLC
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NCT07503808Recruiting

A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types

This is a Phase 1a/1b, open-label, multicenter dose escalation and dose expansion clinical study to evaluate the safety, PK, immunogenicity and preliminary efficacy of IDE034 in participants with loca...

Houston, TXPHASE1150 participantsIDEAYA Biosciences
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NCT05563766Recruiting

A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer

Esophageal cancer, which has a low 5-year overall survival rate (\<20%) is increasing in incidence. Previous studies have shown that Hedgehog, AKT, and angiogenic signaling pathways are activated in a...

Houston, TXPHASE278 participantsVA Office of Research and Development
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NCT06414902Recruiting

18F-AraG PET/CT as a Non-Invasive Imaging Biomarker for Chemoradiation Treatment Response in Esophageal Cancer

To learn if 18F-FAraG PET scans can find tumors in participants with esophageal cancer and predict a participant's response to treatment....

Houston, TXPHASE160 participantsM.D. Anderson Cancer Center
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NCT06123338Recruiting

A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

The purpose of this study to find out whether adding trastuzumab and pembrolizumab to standard chemotherapy is an effective treatment for resectable HER2+ esophagogastric cancer....

Houston, TXPHASE249 participantsMemorial Sloan Kettering Cancer Center
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About Esophageal Cancer Clinical Trials in Houston

Esophageal cancer occurs in the esophagus, the tube connecting the throat to the stomach. The two main types are squamous cell carcinoma and adenocarcinoma. Treatment may include surgery, chemotherapy, radiation, and immunotherapy.

There are currently 9 esophageal cancer clinical trials recruiting participants in Houston, TX. These studies are seeking a combined 1,549 participants. Research is being sponsored by M.D. Anderson Cancer Center, American Association for Cancer Research, Merck Sharp & Dohme LLC and 4 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Esophageal Cancer Clinical Trials in Houston — FAQ

Are there esophageal cancer clinical trials in Houston?

Yes, there are 9 esophageal cancer clinical trials currently recruiting in Houston, TX. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Houston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Houston research site will contact you about next steps.

Are clinical trials in Houston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Houston studies also compensate for your time and travel.

What esophageal cancer treatments are being tested?

The 9 active trials in Houston are testing new therapies including novel drugs, biologics, and treatment approaches for esophageal cancer.

Data updated October 12, 2026 from ClinicalTrials.gov