Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Esophageal Cancer Clinical Trials
Esophageal Cancer clinical trials are recruiting across 95 cities. Here are the cities with the most active studies:
Esophageal Cancer Trial Phases
40 research organizations are sponsoring esophageal cancer trials.
About Esophageal Cancer
Esophageal cancer occurs in the esophagus, the tube connecting the throat to the stomach. The two main types are squamous cell carcinoma and adenocarcinoma. Treatment may include surgery, chemotherapy, radiation, and immunotherapy.
Clinical trials are advancing new treatments for esophageal cancer. Currently, 55 studies are recruiting a combined 29,854 participants across the United States. Research is being conducted by 40 organizations including Universitaire Ziekenhuizen KU Leuven, University of Pittsburgh, Memorial Sloan Kettering Cancer Center and 37 others.
2026 Esophageal Cancer Research Landscape
As of July 2026, the esophageal cancer clinical trial landscape includes 55 actively recruiting studies across 95 cities in the United States. These studies are collectively seeking 29,854 participants, with an average enrollment target of 543 per study.
The research spans multiple phases of development: 27 studies are in PHASE2, 17 studies are in PHASE1, 7 studies are in PHASE3, 7 studies are in NA. The presence of Phase 3 trials indicates that some esophageal cancer treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 40 different organizations, including Universitaire Ziekenhuizen KU Leuven, University of Pittsburgh, Memorial Sloan Kettering Cancer Center, University of Chicago, Pfizer, and 35 others. The large number of sponsors reflects significant research interest and investment in esophageal cancer treatment advancement.
Geographically, esophageal cancer trials are most concentrated in Houston, Texas (12 trials); Pittsburgh, Pennsylvania (8 trials); New York, New York (7 trials); Los Angeles, California (7 trials); Boston, Massachusetts (5 trials) and 7 other cities.
Featured Esophageal Cancer Studies
Highlighted recruiting studies for esophageal cancer, selected by enrollment size and research scope.
Metachronic Brain Metastases After Esophagectomy for Esophageal Cancer (METABREC)
Esophagectomy is the cornerstone of the curative treatment of esophageal carcinoma. Despite this treatment, patients can suffer from locoregional or distant metastatic disease and only a very selected group of patients can be cured: mostly those with recurrence in one single organ. Brain metastases are rare after esophagectomy for cancer, but they have a serious impact on survival. Agressive trea...
Esophageal Cancer Risk Registry
The purpose of this study is to identify markers in the blood and tissue that could indicate risk factors for the development and progression of esophagus cancer. This research aims to collect medical history, blood, and tissue samples from patients who present with an esophageal disorder. Identifying genetic and behavioral risk factors involved in the development of esophageal cancer might allow ...
Retrospective Review of Esophageal Cancer at MSKCC
Residual tumor at the proximal or distal margin after esophagectomy is a known prognostic factor for poor survival outcomes in patients with esophageal cancer; however, the significance of the circumferential resection margin (CRM) remains controversial. In this study, the investigators sought to evaluate the prognostic significance of the CRM in patients with esophageal cancer undergoing resectio...
Frequently Asked Questions About Esophageal Cancer Clinical Trials
Are there esophageal cancer clinical trials near me?
Yes, there are 55 esophageal cancer clinical trials currently recruiting across 95+ cities in the United States, including Houston, Texas; Pittsburgh, Pennsylvania; New York, New York. Browse the studies above to find one at a location convenient for you.
How do I join a esophageal cancer clinical trial?
To join a esophageal cancer clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are esophageal cancer clinical trials free?
Yes, participation in esophageal cancer clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of esophageal cancer treatments are being studied?
Current esophageal cancer clinical trials are testing a range of approaches across PHASE2 (27 studies), PHASE1 (17 studies), PHASE3 (7 studies), NA (7 studies). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 40 research organizations.
Is it safe to participate in esophageal cancer clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 16, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 16, 2026 · Data from ClinicalTrials.gov