Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Colorectal Cancer Clinical Trials
Colorectal Cancer clinical trials are recruiting across 207 cities. Here are the cities with the most active studies:
Colorectal Cancer Trial Phases
75 research organizations are sponsoring colorectal cancer trials.
About Colorectal Cancer
Colorectal cancer starts in the colon or rectum and is the third most common cancer diagnosed in both men and women. Early detection through screening significantly improves outcomes. Treatments include surgery, chemotherapy, radiation, and targeted therapies.
Clinical trials are advancing new treatments for colorectal cancer. Currently, 100 studies are recruiting a combined 141,250 participants across the United States. Research is being conducted by 75 organizations including Natera, Inc., Geneoscopy, Inc., Universal Diagnostics and 72 others.
2026 Colorectal Cancer Research Landscape
As of October 2026, the colorectal cancer clinical trial landscape includes 100 actively recruiting studies across 207 cities in the United States. These studies are collectively seeking 141,250 participants, with an average enrollment target of 1,413 per study.
The research spans multiple phases of development: 21 studies are in NA, 21 studies are in PHASE3, 16 studies are in PHASE2, 12 studies are in PHASE1, 1 study is in PHASE4. The presence of Phase 3 trials indicates that some colorectal cancer treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 75 different organizations, including Natera, Inc., Geneoscopy, Inc., Universal Diagnostics, University of Utah, Vanderbilt University Medical Center, and 70 others. The large number of sponsors reflects significant research interest and investment in colorectal cancer treatment advancement.
Geographically, colorectal cancer trials are most concentrated in Los Angeles, California (23 trials); Duarte, California (15 trials); Aurora, Colorado (11 trials); New York, New York (11 trials); Boston, Massachusetts (11 trials) and 7 other cities.
Featured Colorectal Cancer Studies
Highlighted recruiting studies for colorectal cancer, selected by enrollment size and research scope.
Evaluation of the Natera Colorectal Cancer Screening Test in an Average Risk Population (FIND-CRC)
The FIND-CRC study is a prospective collection of samples and data from participants who are at average risk of developing colorectal cancer (CRC). Collected samples and data will be analyzed to evaluate the clinical performance of the Natera CRC Screening Test.
ColoSense Post-Approval Study
The post-approval study (PAS) described here will supplement existing data generated in the CRC-PREVENT clinical trial. The primary outcomes of this supplemental study will include: clinical sensitivity, clinical specificity, positive predictive value (PPV), and negative predictive value (NPV) of ColoSense.
A Prospective, Multi-center, Observational Study for Signal-C Test Evaluation
To evaluate the performance characteristics of Signal-C™ a plasma circulating free-DNA test, to detect colorectal cancer and advanced precancerous lesions (APL) in an average risk screening population for 45 and over.
Frequently Asked Questions About Colorectal Cancer Clinical Trials
Are there colorectal cancer clinical trials near me?
Yes, there are 100 colorectal cancer clinical trials currently recruiting across 207+ cities in the United States, including Los Angeles, California; Duarte, California; Aurora, Colorado. Browse the studies above to find one at a location convenient for you.
How do I join a colorectal cancer clinical trial?
To join a colorectal cancer clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are colorectal cancer clinical trials free?
Yes, participation in colorectal cancer clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of colorectal cancer treatments are being studied?
Current colorectal cancer clinical trials are testing a range of approaches across NA (21 studies), PHASE3 (21 studies), PHASE2 (16 studies), PHASE1 (12 studies), PHASE4 (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 75 research organizations.
Is it safe to participate in colorectal cancer clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated October 19, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated October 19, 2026 · Data from ClinicalTrials.gov