8 Head and Neck Cancer Clinical Trials in Houston, TX (2026)

Q: How do I join a clinical trial in Houston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Houston research site will contact you.

Recruiting Head and Neck Cancer Studies in Houston

NCT03145077Recruiting

Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Diagnosing Osteoradionecrosis in Patients With Head and Neck Cancer That Is Primary, Has Come Back, or Has Spread to Other Places in the Body

This trial studies how well dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) works in diagnosing osteoradionecrosis in patients with head and neck cancer that is primary, has come back, ...

Houston, TXNA1,400 participantsM.D. Anderson Cancer Center

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NCT06550050Recruiting

Clinical and Molecular Features of Oral Premalignancy and Oral Cancer

Investigators will employ serial assessments of tissue biopsy and additional biomarkers that reflect burden of disease and predict treatment response. Patients enrolled on this study will be given the...

Houston, TX1,000 participantsM.D. Anderson Cancer Center

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NCT05793151Recruiting

Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

The goal of this clinical trial is to compare the effectiveness of a navigation-based multilevel intervention (ENDURE) with treatment as usual (TAU) to improve the initiation of guideline-adherent pos...

Houston, TXNA532 participantsMedical University of South Carolina

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NCT06699212Recruiting

A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases

The goal of this clinical trial is to learn if ASP-1929 photoimmunotherapy (PIT) in combination with pembrolizumab works to treat recurrent squamous cell cancer of the head and neck (HNSCC) with no di...

Houston, TXPHASE3412 participantsRakuten Medical, Inc.

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NCT04003051Recruiting

Web-Based Program in Helping Patients With Head and Neck Cancer Adhere to Swallowing Exercises and Coping Strategies

This phase II trial studies how well a web-based program called Project Prepare works in helping patients with head and neck cancer adhere to swallowing and trismus exercises and coping strategies. He...

Houston, TXPHASE2300 participantsM.D. Anderson Cancer Center

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NCT06030011Recruiting

Implementing the NYU Electronic Patient Visit Assessment (ePVA) for Head and Neck Cancer In Rural and Urban Populations

The PI and the research team developed the New York University (NYU) Electronic Patient Visit Assessment (ePVA) for head and neck cancer (HNC) as a patient-reported outcome measure (PRO) for the early...

Houston, TXNA270 participantsThe University of Texas Health Science Center, Houston

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NCT04870762Recruiting

Customized 3D Printed Oral Stents During Head and Neck Radiotherapy

This clinical trial studies the effect of customized 3 dimensional (3D) printed oral tents on patients with head and neck cancer who are receiving radiotherapy. Oral stents are made from the impressio...

Houston, TXPHASE2119 participantsM.D. Anderson Cancer Center

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NCT07101432Recruiting

Phase I Study of Preconditioning Radiation Therapy With IL-15 Transduced TGFBR2 KO CAR.TROP2-engineered Cord Blood-derived NK Cells in Patients With Advanced Head and Neck Cancer (RADIANCE-NK)

To find the recommended dose of an investigational therapy called chimeric antigen receptor (CAR).TROP2/interleukin (IL)15-transduced TGFBR2 KO cord blood (CB)-derived natural killer (NK) cells (TROP2...

Houston, TXPHASE133 participantsM.D. Anderson Cancer Center

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About Head and Neck Cancer Clinical Trials in Houston

Head and neck cancers develop in the mouth, throat, larynx, sinuses, or salivary glands. HPV-related oropharyngeal cancers have been increasing in prevalence. Treatment includes surgery, radiation, chemotherapy, and immunotherapy.

There are currently 8 head and neck cancer clinical trials recruiting participants in Houston, TX. These studies are seeking a combined 4,066 participants. Research is being sponsored by M.D. Anderson Cancer Center, Medical University of South Carolina, Rakuten Medical, Inc. and 1 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Head and Neck Cancer Clinical Trials in Houston — FAQ

Are there head and neck cancer clinical trials in Houston?

Yes, there are 8 head and neck cancer clinical trials currently recruiting in Houston, TX. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Houston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Houston research site will contact you about next steps.

Are clinical trials in Houston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Houston studies also compensate for your time and travel.

What head and neck cancer treatments are being tested?

The 8 active trials in Houston are testing new therapies including novel drugs, biologics, and treatment approaches for head and neck cancer.

Data updated August 30, 2026 from ClinicalTrials.gov