Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Head and Neck Cancer Clinical Trials
Head and Neck Cancer clinical trials are recruiting across 166 cities. Here are the cities with the most active studies:
Head and Neck Cancer Trial Phases
70 research organizations are sponsoring head and neck cancer trials.
About Head and Neck Cancer
Head and neck cancers develop in the mouth, throat, larynx, sinuses, or salivary glands. HPV-related oropharyngeal cancers have been increasing in prevalence. Treatment includes surgery, radiation, chemotherapy, and immunotherapy.
Clinical trials are advancing new treatments for head and neck cancer. Currently, 100 studies are recruiting a combined 35,913 participants across the United States. Research is being conducted by 70 organizations including Vanderbilt University Medical Center, University Hospital Freiburg, M.D. Anderson Cancer Center and 67 others.
2026 Head and Neck Cancer Research Landscape
As of July 2026, the head and neck cancer clinical trial landscape includes 100 actively recruiting studies across 166 cities in the United States. These studies are collectively seeking 35,913 participants, with an average enrollment target of 359 per study.
The research spans multiple phases of development: 37 studies are in PHASE2, 21 studies are in NA, 16 studies are in PHASE3, 6 studies are in PHASE1, 2 studies are in PHASE4. The presence of Phase 3 trials indicates that some head and neck cancer treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 70 different organizations, including Vanderbilt University Medical Center, University Hospital Freiburg, M.D. Anderson Cancer Center, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, AstraZeneca, and 65 others. The large number of sponsors reflects significant research interest and investment in head and neck cancer treatment advancement.
Geographically, head and neck cancer trials are most concentrated in New York, New York (15 trials); Los Angeles, California (15 trials); La Jolla, California (10 trials); Birmingham, Alabama (9 trials); Houston, Texas (8 trials) and 7 other cities.
Featured Head and Neck Cancer Studies
Highlighted recruiting studies for head and neck cancer, selected by enrollment size and research scope.
Tissue Sample Collection From Patients With Head and Neck Cancer and From Healthy Participants
RATIONALE: Collecting and storing samples of tissue, saliva, and blood from patients with cancer and from healthy participants to study in the laboratory may help the study of cancer in the future. PURPOSE: This research study is collecting and storing tissue samples from patients with head and neck cancer and from healthy participants.
Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy
The number of elderly head-and-neck squamous cell carcinoma (HNSCC) patients is increasing; however, the evidence regarding the ideal treatment for this often vulnerable and frail patient cohort is limited. Although the benefit of concomitant chemotherapy has been reported to decrease in elderly HNSCC patients based on the MACH-NC meta-analysis, it remains unknown whether state-of-the art radiothe...
Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Diagnosing Osteoradionecrosis in Patients With Head and Neck Cancer That Is Primary, Has Come Back, or Has Spread to Other Places in the Body
This trial studies how well dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) works in diagnosing osteoradionecrosis in patients with head and neck cancer that is primary, has come back, or has spread to other places in the body who are undergoing radiation therapy. DCE-MRI may help doctors to predict osteoradionecrosis in patient with head and neck cancer undergoing radiation therapy...
Frequently Asked Questions About Head and Neck Cancer Clinical Trials
Are there head and neck cancer clinical trials near me?
Yes, there are 100 head and neck cancer clinical trials currently recruiting across 166+ cities in the United States, including New York, New York; Los Angeles, California; La Jolla, California. Browse the studies above to find one at a location convenient for you.
How do I join a head and neck cancer clinical trial?
To join a head and neck cancer clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are head and neck cancer clinical trials free?
Yes, participation in head and neck cancer clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of head and neck cancer treatments are being studied?
Current head and neck cancer clinical trials are testing a range of approaches across PHASE2 (37 studies), NA (21 studies), PHASE3 (16 studies), PHASE1 (6 studies), PHASE4 (2 studies). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 70 research organizations.
Is it safe to participate in head and neck cancer clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 17, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 17, 2026 · Data from ClinicalTrials.gov