Palo Alto, CALIFORNIA6 Active Studies

Head and Neck Cancer Clinical Trials in Palo Alto, CALIFORNIA

Find 6 actively recruiting head and neck cancer clinical trials in Palo Alto, CALIFORNIA. Connect with local research sites and explore new treatment options.

6
Active Trials
3
Sponsors
1,714
Enrolling

Recruiting Head and Neck Cancer Studies in Palo Alto

RecruitingPalo Alto, CALIFORNIANCT06496178

A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients

This is a phase 3 open-label, randomized, controlled, multicenter study to compare petosemtamab vs investigator's choice monotherapy in HNSCC patients for the second- and third-line treatment of incur...

500 participants
Merus N.V.
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RecruitingPalo Alto, CALIFORNIANCT06525220

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

This is a Phase 3 randomized, open-label study to evaluate the efficacy and safety of petosemtamab plus pembrolizumab vs pembrolizumab in first-line treatment of recurrent or metastatic PD-L1+ head an...

500 participants
Merus N.V.
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RecruitingPalo Alto, CALIFORNIANCT04534205

A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1

An open-label, controlled, multi-site, interventional, 2-arm, Phase II/III trial of BNT113 in combination with pembrolizumab vs pembrolizumab monotherapy as first line treatment in patients with unres...

350 participants
BioNTech SE
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RecruitingPalo Alto, CALIFORNIANCT06589804

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

This phase III trial compares the effect of adding cetuximab to pembrolizumab versus pembrolizumab alone in treating patients with head and neck squamous cell carcinoma (HNSCC) that has come back afte...

158 participants
National Cancer Institute (NCI)
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RecruitingPalo Alto, CALIFORNIANCT06029270

Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancer

This phase II trial tests the addition of BMS-986016 (relatlimab) to the usual immunotherapy after initial treatment for nasopharyngeal cancer that has come back after a period of improvement (recurre...

156 participants
National Cancer Institute (NCI)
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RecruitingPalo Alto, CALIFORNIANCT05904080

Testing Nivolumab and Ipilimumab Immunotherapy With or Without the Targeted Drug Cabozantinib in Recurrent, Metastatic, or Incurable Nasopharyngeal Cancer

This phase II trial tests how well nivolumab and ipilimumab immunotherapy with or without cabozantinib works in treating patients with nasopharyngeal cancer that has come back (after a period of impro...

50 participants
National Cancer Institute (NCI)
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About Head and Neck Cancer Clinical Trials in Palo Alto

Head and neck cancers develop in the mouth, throat, larynx, sinuses, or salivary glands. HPV-related oropharyngeal cancers have been increasing in prevalence. Treatment includes surgery, radiation, chemotherapy, and immunotherapy.

There are currently 6 head and neck cancer clinical trials recruiting participants in Palo Alto, CALIFORNIA. These studies are seeking a combined 1,714 participants. Research is being sponsored by Merus N.V., BioNTech SE, National Cancer Institute (NCI). Clinical trial participation is free and participants receive study-related medical care at no cost.

Head and Neck Cancer Clinical Trials in Palo Alto — FAQ

Are there head and neck cancer clinical trials in Palo Alto?

Yes, there are 6 head and neck cancer clinical trials currently recruiting in Palo Alto, CALIFORNIA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Palo Alto?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Palo Alto research site will contact you about next steps.

Are clinical trials in Palo Alto free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Palo Alto studies also compensate for your time and travel.

What head and neck cancer treatments are being tested?

The 6 active trials in Palo Alto are testing new therapies including novel drugs, biologics, and treatment approaches for head and neck cancer.

Data updated March 2, 2026 from ClinicalTrials.gov