8 Depression Clinical Trials in Huntsville, NC (2026)

Q: How do I join a clinical trial in Huntsville?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Huntsville research site will contact you.

Recruiting Depression Studies in Huntsville

NCT03887715Recruiting

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multip...

Huntsville, NC6,800 participantsLivaNova

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NCT06966401Recruiting

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

This study will evaluate the long-term safety and tolerability of NBI-1065845 as an adjunctive treatment in participants with MDD....

Huntsville, NC850 participantsNeurocrine Biosciences

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NCT05850689Recruiting

Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

This is a multicenter, randomized, double-blind, placebo-controlled parallel-group, fixed-dose study in patients with a primary diagnosis of MDD according to criteria of the Diagnostic and Statistical...

Huntsville, NC470 participantsIntra-Cellular Therapies, Inc.

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NCT07076407Recruiting

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

X-NOVA3 is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of azetukalner as a monotherapy in adult participants ...

Huntsville, NC450 participantsXenon Pharmaceuticals Inc.

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NCT04923685Recruiting

MicroRNA Correlates of Childhood Maltreatment and Suicidality

This is a research study to find out if childhood trauma and stress are associated with depression or suicidal risk. The study will assess the effects of both short-term and long-term stress on biomar...

Huntsville, NC450 participantsUniversity of Alabama at Birmingham

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NCT05437588Recruiting

Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents

This study is dedicated to help identify biomarkers for depression and suicide. The purpose of the study is to better understand these links to improve medical and psychiatric care in the future. This...

Huntsville, NC240 participantsUniversity of Alabama at Birmingham

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NCT06911112Recruiting

NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depression....

Huntsville, NC200 participantsNeurocrine Biosciences

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NCT06547489Recruiting

GATE-251 or Placebo for the Reduction of Symptoms of Major Depressive Disorder

The goal of this clinical trial is to learn if GATE-251 works to treat depression in adults. It will also learn about the safety of GATE-251. The main questions it aims to answer are: Does GATE-251 r...

Huntsville, NC164 participantsSyndeio Biosciences, Inc

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About Depression Clinical Trials in Huntsville

Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.

There are currently 8 depression clinical trials recruiting participants in Huntsville, NC. These studies are seeking a combined 9,624 participants. Research is being sponsored by LivaNova, Neurocrine Biosciences, Intra-Cellular Therapies, Inc. and 3 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Depression Clinical Trials in Huntsville — FAQ

Are there depression clinical trials in Huntsville?

Yes, there are 8 depression clinical trials currently recruiting in Huntsville, NC. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Huntsville?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Huntsville research site will contact you about next steps.

Are clinical trials in Huntsville free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Huntsville studies also compensate for your time and travel.

What depression treatments are being tested?

The 8 active trials in Huntsville are testing new therapies including novel drugs, biologics, and treatment approaches for depression.

Data updated July 13, 2026 from ClinicalTrials.gov