4 Sickle Cell Disease Clinical Trials in Indianapolis, IN (2026)

Q: How do I join a clinical trial in Indianapolis?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Indianapolis research site will contact you.

Recruiting Sickle Cell Disease Studies in Indianapolis

NCT06941389Recruiting

Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease

The WeDecide study is a large observational study comparing the long-term effects of matched related donor hematopoietic stem cell transplantation (MRD HCT) and non-transplant disease-modifying therap...

Indianapolis, IN480 participantsUniversity of Rochester

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NCT06975865Recruiting

The Efficacy and Safety of Rilzabrutinib in Patients Aged 10 to 65 Years With Sickle-cell Disease

This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, group-sequential study (Part A), followed by an open-label LTE period (Part B) to investigate the efficacy, and saf...

Indianapolis, INPHASE3192 participantsSanofi

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NCT07656415Recruiting

A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)

The primary objective of this study is to determine the effect of mitapivat versus placebo on the need for transfusions in subjects with SCD....

Indianapolis, INPHASE3159 participantsAgios Pharmaceuticals, Inc.

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NCT07187973Recruiting

A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)

This is an open-label, multicenter, within-participant dose-escalation study examining up to 3 dose levels of DISC-3405 and will assess the safety, tolerability, PK, and PD of DISC 3405 in participant...

Indianapolis, INPHASE124 participantsDisc Medicine, Inc

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About Sickle Cell Disease Clinical Trials in Indianapolis

Sickle cell disease is a group of inherited blood disorders where abnormal hemoglobin causes red blood cells to become rigid and sickle-shaped. It causes pain crises, organ damage, and shortened life expectancy. Treatment includes hydroxyurea, blood transfusions, and gene therapy.

There are currently 4 sickle cell disease clinical trials recruiting participants in Indianapolis, IN. These studies are seeking a combined 855 participants. Research is being sponsored by University of Rochester, Sanofi, Agios Pharmaceuticals, Inc. and 1 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Sickle Cell Disease Clinical Trials in Indianapolis — FAQ

Are there sickle cell disease clinical trials in Indianapolis?

Yes, there are 4 sickle cell disease clinical trials currently recruiting in Indianapolis, IN. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Indianapolis?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Indianapolis research site will contact you about next steps.

Are clinical trials in Indianapolis free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Indianapolis studies also compensate for your time and travel.

What sickle cell disease treatments are being tested?

The 4 active trials in Indianapolis are testing new therapies including novel drugs, biologics, and treatment approaches for sickle cell disease.

Data updated October 15, 2026 from ClinicalTrials.gov