23 Rheumatoid Arthritis Clinical Trials in Iowa City, IA (2026)

Q: How do I join a clinical trial in Iowa City?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Iowa City research site will contact you.

Recruiting Rheumatoid Arthritis Studies in Iowa City

NCT05354141Recruiting

Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS)

To evaluate the safety and efficacy of intravenous (IV) administration of bone marrow mesenchymal stem cell derived extracellular vesicles (EVs), ExoFlo, versus placebo for the treatment of hospitaliz...

Iowa City, IAPHASE3970 participantsDirect Biologics, LLC

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NCT05046600Recruiting

Registry of Arthrex Hand and Wrist Products

A Multi-Center, Prospective Registry to Evaluate the Continued Safety and Effectiveness of Hand and Wrist Products...

Iowa City, IA650 participantsArthrex, Inc.

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NCT05844982Recruiting

Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 Mg) Intravitreal Implants Vs Observation for Prevention of VA Loss Due to Radiation Retinopathy

This randomized controlled trial will evaluate the effect of intravitreal faricimab or fluocinolone acetonide (FAc) intravitreal implant compared with observation on long-term visual acuity following ...

Iowa City, IAPHASE3600 participantsJaeb Center for Health Research

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NCT06026410Recruiting

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

This first-in-human (FIH) dose-escalation and dose-validation/expansion study will assess KO-2806, a farnesyltransferase inhibitor (FTI), as a monotherapy and in combination, in adult patients with ad...

Iowa City, IAPHASE1300 participantsKura Oncology, Inc.

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NCT06013865Recruiting

Empagliflozin Treatment in Kidney Transplant Recipients

Kidney transplantation improves the health and quality of life for those Veterans with end stage kidney disease (ESKD). While early patient and graft survival are excellent, long-term outcomes continu...

Iowa City, IAPHASE4264 participantsVA Office of Research and Development

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NCT06213649Recruiting

Parasitic Ulcer Treatment Trial

The Parasitic Ulcer Treatment Trial (PUTT) is a multi-center, parallel-group, randomized clinical trial. The purpose of this study is to determine whether including topical corticosteroids in a regime...

Iowa City, IAPHASE3232 participantsJeremy Keenan, MD, MPH

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NCT07038200Recruiting

A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD

A Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous AOC 1020 for the Treatment of Facioscapulohumeral Muscular Dystrophy (FSHD)...

Iowa City, IAPHASE3200 participantsAvidity Biosciences, Inc.

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NCT04115241Recruiting

Activity Levels in Bone Marrow Transplant Patients

Participants in this study will be receiving a bone marrow transplant. This study is designed to evaluate correlations between activity levels and length of stay, quality of life, and hand grip streng...

Iowa City, IA200 participantsMichael Tomasson

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NCT06822426Recruiting

Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC)

This is a Phase 3, randomized, double-blind, controlled, adaptive, 2-arm, multicenter study to demonstrate the efficacy and safety of DefenCath in adult participants receiving home Total Parenteral Nu...

Iowa City, IAPHASE3200 participantsCorMedix

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NCT07180537Recruiting

Creating Health Course Study for People With Rheumatological Conditions

The goal of this project is to critically evaluate the effectiveness of an online health program designed to improve diet and self-care in patients with rheumatological conditions, including rheumatoi...

Iowa City, IANA200 participantsTerry L. Wahls

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NCT06406777Recruiting

Chronic Lung Allograft Dysfunction MRI Study

This studies purpose is to confirm the efficacy and efficiency of using OE-MRI and MRI with hyperpolarized gas techniques and Iodinated contrast CT scan, this will enhance understanding of CLAD pathop...

Iowa City, IAPHASE1100 participantsSean Fain

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NCT05654922Recruiting

Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant

The goal of this Phase 3 clinical trial is to compare ARINA-1 (a nebulized immunomodulatory agent) plus Standard of Care vs Standard of Care alone. The main question it aims to answer are: * Evaluate...

Iowa City, IAPHASE3100 participantsRenovion, Inc.

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NCT05932680Recruiting

Limited-duration Teclistamab

This is a single-arm, non-inferiority study in which patients who have achieved a very good partial response (VGPR) or better, according to International Myeloma Working Group (IMWG) response criteria...

Iowa City, IAPHASE275 participantsAbramson Cancer Center at Penn Medicine

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NCT06050668Recruiting

Essential Amino Acid Supplementation for Femoral Fragility Fractures

This trial will evaluate the impact of 4 weeks of postoperative essential amino acid (EAA)-based supplementation on muscle morphology after femoral fragility fracture. This trial will assess the abili...

Iowa City, IAPHASE260 participantsMichael C Willey

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NCT05868330Recruiting

Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties

Comparison of post-operative pain after total shoulder surgery. The Principle Investigator will be comparing Exparel single shot block to Interscalene catheter...

Iowa City, IAPHASE456 participantsMelinda Seering

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NCT07571746Recruiting

A Study to Assess the Effect of Surovatamig in Adult Participants With Antibody-mediated Kidney Disease

The purpose of this study is to assess the safety, tolerability, pharmacokinetic, and efficacy of surovatamig administered by subcutaneous injection in adult participants with primary membranous nephr...

Iowa City, IAPHASE243 participantsAstraZeneca

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NCT06194929Recruiting

Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma

The goal of this interventional clinical trial is to provide proof-of-principle data for the biologic activity of defactinib in combination with avutometinib in brain metastases from melanoma, and to ...

Iowa City, IAPHASE133 participantsUniversity of Utah

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NCT05582993Recruiting

A Study of Vonicog Alfa (rVWF) in Children With Severe Von Willebrand Disease (vWD)

The main aim of the study is to evaluate the effectiveness of prophylaxis with vonicog alfa (recombinant von Willebrand factor \[rVWF\]) in children. This study will enroll those participants who have...

Iowa City, IAPHASE324 participantsTakeda

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NCT00567073Recruiting

Pompe Pregnancy Sub-Registry

This Sub-registry is a multicenter, international, longitudinal, observational, and voluntary program designed to track pregnancy outcomes for any pregnant woman enrolled in the Pompe Registry, regard...

Iowa City, IA20 participantsGenzyme, a Sanofi Company

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NCT06664710Recruiting

Evaluation of the Automated Integration of a Robotics and ECochG System for Use With Cochlear Implant Surgery

Evaluation of the Automated Integration of a Robotics and ECochG System for Use with Cochlear Implant Surgery...

Iowa City, IANA10 participantsiotaMotion, Inc.

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NCT06422923Recruiting

A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)

This is a multicenter, single arm, open label clinical trial that is designed to test the safety and preliminary efficacy of single administration inhibitory nerve cells called interneurons (NRTX-1001...

Iowa City, IAPHASE110 participantsNeurona Therapeutics

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NCT05040373Recruiting

Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance Program

The purpose of this study is to collect and evaluate pregnancy outcomes, pregnancy complications, and fetal/neonatal/infant outcomes in women exposed to patisiran-LNP....

Iowa City, IA10 participantsAlnylam Pharmaceuticals

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NCT03420339Recruiting

Stimulant Effects on Disruptive Behavior

The goal of this study is to determine the effects of stimulant medication on disruptive behavior, function, preference and choice; however, it is primarily methodological and will add to current rese...

Iowa City, IAPHASE410 participantsMatthew J O'Brien, PhD, BCBA-D

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About Rheumatoid Arthritis Clinical Trials in Iowa City

Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting approximately 1.3 million Americans, where the immune system mistakenly attacks joint linings, causing painful swelling, bone erosion, and joint deformity. Early diagnosis and treatment are critical to prevent irreversible damage. Current standard treatments include methotrexate and other DMARDs, TNF inhibitors (etanercept, infliximab), IL-6 inhibitors (tocilizumab), T-cell costimulation modulators (abatacept), and JAK inhibitors (tofacitinib, baricitinib). Clinical trials are now exploring next-generation targeted therapies, dual-pathway inhibitors, and treatment strategies aimed at achieving sustained remission rather than just symptom control. Patients with inadequate response to conventional DMARDs or biologics are commonly eligible for enrollment.

There are currently 23 rheumatoid arthritis clinical trials recruiting participants in Iowa City, IA. These studies are seeking a combined 4,367 participants. Research is being sponsored by Direct Biologics, LLC, Arthrex, Inc., Jaeb Center for Health Research and 20 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Rheumatoid Arthritis Clinical Trials in Iowa City — FAQ

Are there rheumatoid arthritis clinical trials in Iowa City?

Yes, there are 23 rheumatoid arthritis clinical trials currently recruiting in Iowa City, IA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Iowa City?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Iowa City research site will contact you about next steps.

Are clinical trials in Iowa City free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Iowa City studies also compensate for your time and travel.

What rheumatoid arthritis treatments are being tested?

The 23 active trials in Iowa City are testing new therapies including novel drugs, biologics, and treatment approaches for rheumatoid arthritis.

Data updated July 16, 2026 from ClinicalTrials.gov