8 Depression Clinical Trials in La Jolla, CA (2026)

Q: How do I join a clinical trial in La Jolla?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the La Jolla research site will contact you.

Recruiting Depression Studies in La Jolla

NCT03887715Recruiting

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multip...

La Jolla, CANA6,800 participantsLivaNova

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NCT07076407Recruiting

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

X-NOVA3 is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of azetukalner as a monotherapy in adult participants ...

La Jolla, CAPHASE3450 participantsXenon Pharmaceuticals Inc.

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NCT06564818Recruiting

"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"

The purpose of this study is to examine the efficacy, safety, and tolerability of CYB003 compared to matching placebo as adjunctive treatment in participants with MDD....

La Jolla, CAPHASE3220 participantsCybin IRL Limited

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NCT07284667Recruiting

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

The goal of this clinical trial is to learn if ACP-211 can help treat adults with major depressive disorder (MDD) who have not improved with antidepressant therapy (ADT), including those with treatmen...

La Jolla, CAPHASE2153 participantsACADIA Pharmaceuticals Inc.

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NCT06524830Recruiting

A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

This Phase 2 study (protocol number VLS-01-203) will determine the efficacy, safety, and tolerability of short-term treatment with a VLS-01 transmucosal buccal film (VLS-01-BU) in patients with treatm...

La Jolla, CAPHASE2142 participantsatai Therapeutics, Inc.

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NCT05682677Recruiting

Combined Neuromodulation and Cognitive Training for Post-mTBI Depression

The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in...

La Jolla, CANA72 participantsUniversity of California, San Diego

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NCT07490782Recruiting

Nutritional Intervention for College Students With Depression

The goal of this clinical trial is to assess the feasibility of nutritional interventions in college students with depression. The main outcomes it aims to measure are: * Nutritional content, meal ti...

La Jolla, CANA30 participantsUniversity of California, San Diego

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NCT06675240Recruiting

Meditative Neurofeedback for Depression

The goal of this open-label single-arm study is to test a meditative neurofeedback intervention for depressed mood....

La Jolla, CANA27 participantsUniversity of California, San Diego

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About Depression Clinical Trials in La Jolla

Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.

There are currently 8 depression clinical trials recruiting participants in La Jolla, CA. These studies are seeking a combined 7,894 participants. Research is being sponsored by LivaNova, Xenon Pharmaceuticals Inc., Cybin IRL Limited and 3 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Depression Clinical Trials in La Jolla — FAQ

Are there depression clinical trials in La Jolla?

Yes, there are 8 depression clinical trials currently recruiting in La Jolla, CA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in La Jolla?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the La Jolla research site will contact you about next steps.

Are clinical trials in La Jolla free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many La Jolla studies also compensate for your time and travel.

What depression treatments are being tested?

The 8 active trials in La Jolla are testing new therapies including novel drugs, biologics, and treatment approaches for depression.

Data updated July 18, 2026 from ClinicalTrials.gov