9 Head and Neck Cancer Clinical Trials in La Jolla, CA (2026)

Q: How do I join a clinical trial in La Jolla?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the La Jolla research site will contact you.

Recruiting Head and Neck Cancer Studies in La Jolla

NCT06525220Recruiting

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

This is a Phase 3 randomized, open-label study to evaluate the efficacy and safety of petosemtamab plus pembrolizumab vs pembrolizumab in first-line treatment of recurrent or metastatic PD-L1+ head an...

La Jolla, CAPHASE3700 participantsMerus N.V.

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NCT06788990Recruiting

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

Ficerafusp alfa is directed against two targets, Epidermal Growth Factor Receptor (EGFR) and Transforming Growth Factor beta (TGF-β). This study intends to evaluate the safety and efficacy of ficeraf...

La Jolla, CAPHASE2650 participantsBicara Therapeutics

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NCT01810913Recruiting

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage I...

La Jolla, CAPHASE2613 participantsNational Cancer Institute (NCI)

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NCT06496178Recruiting

A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients

This is a phase 3 open-label, randomized, controlled, multicenter study to compare petosemtamab vs investigator's choice monotherapy in HNSCC patients for the second- and third-line treatment of incur...

La Jolla, CAPHASE3600 participantsMerus N.V.

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NCT04892173Recruiting

JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC

This is a global, open-label, randomized, 2-arm, Investigator's choice Phase 3 (Pivotal Stage) study to investigate the efficacy and safety of JNJ-90301900 (NBTXR3) / radiation therapy (RT)±cetuximab ...

La Jolla, CAPHASE3500 participantsJohnson & Johnson Enterprise Innovation Inc.

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NCT06385080Recruiting

A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Recurrent/Metastatic Head and Neck Cancer

The purpose of this study is to determine safety and preliminary efficacy of amivantamab monotherapy, amivantamab in addition to pembrolizumab, amivantamab in addition to paclitaxel and amivantamab in...

La Jolla, CAPHASE1287 participantsJanssen Research & Development, LLC

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NCT04671667Recruiting

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

This phase II trial studies the effect of pembrolizumab alone compared to the usual approach (chemotherapy \[cisplatin and carboplatin\] plus radiation therapy) after surgery in treating patients with...

La Jolla, CAPHASE2188 participantsNational Cancer Institute (NCI)

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NCT03480971Recruiting

Treatment of Radiation and Cisplatin Induced Toxicities with Tempol

A 10 week trial to assess the ability of Tempol to prevent and/or reduce toxicities associated with cisplatin and radiation treatment in head and neck cancer patients. Over the course of the 10 week t...

La Jolla, CAPHASE2120 participantsMatrix Biomed, Inc.

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NCT06532279Recruiting

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

This phase II trial compares the effectiveness of adding BMX-001 to usual symptom management versus usual symptom management alone for reducing oral mucositis in patients who are receiving chemoradiat...

La Jolla, CAPHASE298 participantsNRG Oncology

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About Head and Neck Cancer Clinical Trials in La Jolla

Head and neck cancers develop in the mouth, throat, larynx, sinuses, or salivary glands. HPV-related oropharyngeal cancers have been increasing in prevalence. Treatment includes surgery, radiation, chemotherapy, and immunotherapy.

There are currently 9 head and neck cancer clinical trials recruiting participants in La Jolla, CA. These studies are seeking a combined 3,756 participants. Research is being sponsored by Merus N.V., Bicara Therapeutics, National Cancer Institute (NCI) and 4 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Head and Neck Cancer Clinical Trials in La Jolla — FAQ

Are there head and neck cancer clinical trials in La Jolla?

Yes, there are 9 head and neck cancer clinical trials currently recruiting in La Jolla, CA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in La Jolla?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the La Jolla research site will contact you about next steps.

Are clinical trials in La Jolla free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many La Jolla studies also compensate for your time and travel.

What head and neck cancer treatments are being tested?

The 9 active trials in La Jolla are testing new therapies including novel drugs, biologics, and treatment approaches for head and neck cancer.

Data updated July 18, 2026 from ClinicalTrials.gov