11 Spinal Muscular Atrophy Clinical Trials in Lexington, MA (2026)

Q: How do I join a clinical trial in Lexington?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Lexington research site will contact you.

Recruiting Spinal Muscular Atrophy Studies in Lexington

NCT04165798Recruiting

KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

This study is referred to as the "umbrella master protocol" for pembrolizumab (MK-3475) in the treatment of non-small cell lung cancer (NSCLC). This pembrolizumab NSCLC umbrella master protocol uses a...

Lexington, MA1,065 participantsMerck Sharp & Dohme LLC

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NCT06203210Recruiting

A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer

This study was designed to compare the efficacy and safety of I-DXd with treatment of physician's choice in participants with relapsed small cell lung cancer (SCLC)....

Lexington, MAPHASE3540 participantsDaiichi Sankyo

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NCT04165070Recruiting

KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

The purpose of this study is to assess the efficacy and safety of pembrolizumab (MK-3475) with or without chemotherapy in combination with vibostolimab (MK-7684), boserolimab (MK-5890), MK-4830, MK-04...

Lexington, MAPHASE1450 participantsMerck Sharp & Dohme LLC

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NCT05142189Recruiting

Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer

This first-in-human (FIH) study for BNT116 aims to establish the safety profile and a safe dose for BNT116 monotherapy as well as for BNT116 in combination with approved medicinal products and/or in c...

Lexington, MAPHASE1320 participantsBioNTech SE

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NCT05882058Recruiting

DAREON™-5: A Study to Test Whether Different Doses of BI 764532 Help People With Small Cell Lung Cancer or Other Neuroendocrine Cancers

This study is open to adults with small cell lung cancer and other neuroendocrine tumours. The study is in people with advanced cancer for whom previous treatment was not successful or no standard tre...

Lexington, MAPHASE2204 participantsBoehringer Ingelheim

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NCT07155174Recruiting

A Study to Evaluate the Optimal Dose, Adverse Events and Change in Disease Activity of Intravenous ABBV-706 in Combination With Atezolizumab Versus Standard of Care as First-Line Treatment in Adult Participants With Previously Untreated Extensive Stage Small Cell Lung Cancer

Small cell lung cancer (SCLC) is characterized by aggressive and rapid growth and a tendency to develop early spread to distant sites including mediastinal lymph nodes, liver, bones, adrenal glands, a...

Lexington, MAPHASE2180 participantsAbbVie

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NCT06780085Recruiting

A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)

Researchers are looking for new ways to treat metastatic nonsquamous non-small cell lung cancer (NSCLC) that has been treated before. Metastatic means the cancer has spread to other parts of the body....

Lexington, MAPHASE296 participantsMerck Sharp & Dohme LLC

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NCT06731907Recruiting

A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)

Researchers are investigating new treatments for untreated advanced non-small cell lung cancer (NSCLC), which is the most common form of lung cancer and lung cancer that has spread beyond surgical rem...

Lexington, MAPHASE290 participantsMerck Sharp & Dohme LLC

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NCT07564401Recruiting

A Study to Evaluate DJI136, a DLL3-targeted CAR-T Therapy

This is a Phase I/II, open-label, non-randomized, multi-center study in patients with extensive-stage small cell lung cancer (ES-SCLC) to determine the recommended dose(s) (RD) and to evaluate the saf...

Lexington, MAPHASE180 participantsNovartis Pharmaceuticals

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NCT06592638Recruiting

A Phase 1 Dose Escalation Study of ZG006 in Patients With Small Cell Lung Cancer

This is a multi-center, open-label, Phase 1 clinical study of ZG006 in the US for the treatment of subjects with small cell lung cancer who have failed or are intolerant to available standard treatmen...

Lexington, MAPHASE130 participantsSuzhou Zelgen Biopharmaceuticals Co.,Ltd

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NCT06119061Recruiting

Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With External Ventricular Drainage

The proposed study aims to evaluate the CNS penetration of telavancin in a critically ill population using cerebrospinal fluid (CSF) drawn from external ventricular drains (EVDs). Patients with EVDs w...

Lexington, MAPHASE420 participantsAaron Cook

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About Spinal Muscular Atrophy Clinical Trials in Lexington

Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder that causes loss of motor neurons, leading to progressive muscle weakness and atrophy. It is the leading genetic cause of infant death. Revolutionary gene therapies and SMN-enhancing drugs have transformed treatment.

There are currently 11 spinal muscular atrophy clinical trials recruiting participants in Lexington, MA. These studies are seeking a combined 3,075 participants. Research is being sponsored by Merck Sharp & Dohme LLC, Daiichi Sankyo, BioNTech SE and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Spinal Muscular Atrophy Clinical Trials in Lexington — FAQ

Are there spinal muscular atrophy clinical trials in Lexington?

Yes, there are 11 spinal muscular atrophy clinical trials currently recruiting in Lexington, MA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Lexington?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Lexington research site will contact you about next steps.

Are clinical trials in Lexington free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Lexington studies also compensate for your time and travel.

What spinal muscular atrophy treatments are being tested?

The 11 active trials in Lexington are testing new therapies including novel drugs, biologics, and treatment approaches for spinal muscular atrophy.

Data updated July 18, 2026 from ClinicalTrials.gov