Newport Beach, CALIFORNIA10 Active Studies

Lung Cancer Clinical Trials in Newport Beach, CALIFORNIA

Find 10 actively recruiting lung cancer clinical trials in Newport Beach, CALIFORNIA. Connect with local research sites and explore new treatment options.

10
Active Trials
8
Sponsors
4,688
Enrolling

Recruiting Lung Cancer Studies in Newport Beach

RecruitingNewport Beach, CALIFORNIANCT05555732

Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)

This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab in combination with pemetrexed and platinum chemoth...

1,170 participants
Daiichi Sankyo
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RecruitingNewport Beach, CALIFORNIANCT06216301

LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

This study, known as LUNAR-2, aims to investigate the effectiveness and safety of using TTFields, delivered by the NovoTTF-200T device, concomitantly administered with pembrolizumab and platinum-based...

734 participants
NovoCure GmbH
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RecruitingNewport Beach, CALIFORNIANCT06357533

Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

The purpose of this study is to evaluate efficacy and safety of Dato-DXd in combination with rilvegostomig or rilvegostomig monotherapy compared with pembrolizumab monotherapy as a first line therapy ...

675 participants
AstraZeneca
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RecruitingNewport Beach, CALIFORNIANCT06564844

A Phase III, Randomised Study of Adjuvant Dato-DXd in Combination With Rilvegostomig or Rilvegostomig Monotherapy Versus Standard of Care, Following Complete Tumour Resection, in Participants With Stage I Adenocarcinoma NSCLC Who Are ctDNA-positive or Have High-risk Pathological Features

This is a Phase III, randomised, open-label, multicentre, global study assessing the efficacy and safety of adjuvant Dato-DXd in combination with rilvegostomig compared with SoC, after complete surgic...

660 participants
AstraZeneca
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RecruitingNewport Beach, CALIFORNIANCT06875310

A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemothera...

630 participants
Mirati Therapeutics Inc.
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RecruitingNewport Beach, CALIFORNIANCT06120140

Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib

The purpose of this study is to evaluate whether enhanced dermatologic management can reduce incidence of grade greater than or equal to (\>=) 2 dermatologic adverse events of interest (DAEIs) when co...

300 participants
Janssen Research & Development, LLC
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RecruitingNewport Beach, CALIFORNIANCT06452277

A Study to Learn More About How Well Sevabertinib (BAY 2927088) Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

Researchers are looking for a better way to treat people who have advanced non-small cell lung cancer (NSCLC) with specific genetic changes called human epidermal growth factor receptor 2 (HER2) mutat...

278 participants
Bayer
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RecruitingNewport Beach, CALIFORNIANCT06362252

A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer (IDeate-Lung03)

This study is designed to evaluate the safety and efficacy of ifinatamab deruxtecan (I-DXd) in combination with immune checkpoint inhibitor (ICI) atezolizumab with or without carboplatin in participan...

123 participants
Daiichi Sankyo
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RecruitingNewport Beach, CALIFORNIANCT06946797

A Study to Evaluate Two Dosing Regimens of Subcutaneous Nivolumab in Combination With Intravenous Ipilimumab and Chemotherapy in Participants With Previously Untreated Metastatic or Recurrent Non-Small Cell Lung Cancer (NSCLC)

The purpose of this study is to evaluate two dosing regimens of subcutaneous Nivolumab in combination with intravenous Ipilimumab and chemotherapy in participants with previously untreated metastatic ...

76 participants
Bristol-Myers Squibb
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RecruitingNewport Beach, CALIFORNIANCT05198830

Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer

This phase II trial tests whether TRC102 (methoxyamine hydrochloride) in combination usual care treatment comprised of pemetrexed, cisplatin or carboplatin, and radiation therapy followed by durvaluma...

42 participants
National Cancer Institute (NCI)
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About Lung Cancer Clinical Trials in Newport Beach

Lung cancer is the leading cause of cancer death worldwide, starting in the cells of the lungs. The two main types are non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Treatments include surgery, chemotherapy, radiation, immunotherapy, and targeted drugs.

There are currently 10 lung cancer clinical trials recruiting participants in Newport Beach, CALIFORNIA. These studies are seeking a combined 4,688 participants. Research is being sponsored by Daiichi Sankyo, NovoCure GmbH, AstraZeneca and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Lung Cancer Clinical Trials in Newport Beach — FAQ

Are there lung cancer clinical trials in Newport Beach?

Yes, there are 10 lung cancer clinical trials currently recruiting in Newport Beach, CALIFORNIA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Newport Beach?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Newport Beach research site will contact you about next steps.

Are clinical trials in Newport Beach free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Newport Beach studies also compensate for your time and travel.

What lung cancer treatments are being tested?

The 10 active trials in Newport Beach are testing new therapies including novel drugs, biologics, and treatment approaches for lung cancer.

Data updated March 2, 2026 from ClinicalTrials.gov