Newport Beach, CALIFORNIA10 Active Studies

Breast Cancer Clinical Trials in Newport Beach, CALIFORNIA

Find 10 actively recruiting breast cancer clinical trials in Newport Beach, CALIFORNIA. Connect with local research sites and explore new treatment options.

10
Active Trials
9
Sponsors
12,177
Enrolling

Recruiting Breast Cancer Studies in Newport Beach

RecruitingNewport Beach, CALIFORNIANCT01042379

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learn...

5,000 participants
QuantumLeap Healthcare Collaborative
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RecruitingNewport Beach, CALIFORNIANCT06492616

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

The primary goal of this study is to evaluate the effectiveness of elacestrant versus standard endocrine therapy in participants with node-positive, Estrogen Receptor-positive (ER+), Human Epidermal G...

4,220 participants
Stemline Therapeutics, Inc.
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RecruitingNewport Beach, CALIFORNIANCT06065748

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

This is a Phase III, randomized, open-label multicenter study that will evaluate the efficacy and safety of giredestrant compared with fulvestrant, both in combination with the investigator's choice o...

1,050 participants
Hoffmann-La Roche
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RecruitingNewport Beach, CALIFORNIANCT04862663

Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)

A Phase Ib/III Open-label, Randomised Study of Capivasertib plus CDK4/6 Inhibitors and Fulvestrant versus CDK4/6 Inhibitors and Fulvestrant in Hormone Receptor-Positive and Human Epidermal Growth Fact...

895 participants
AstraZeneca
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RecruitingNewport Beach, CALIFORNIANCT06380751

Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

The primary objective of the study is to measure efficacy of saruparib (AZD5305) plus camizestrant compared with physician's choice CDK4/6i plus ET in patients with BRCA1, BRCA2, or PALB2m, HR-positiv...

500 participants
AstraZeneca
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RecruitingNewport Beach, CALIFORNIANCT06993844

Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors

Phase 1/2, open-label study of ETX-636 in participants with advanced solid tumors...

233 participants
Ensem Therapeutics
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RecruitingNewport Beach, CALIFORNIANCT06428396

Study of Belzutifan (MK-6482) Plus Fulvestrant for ER+/HER2- Metastatic Breast Cancer (MK-6482-029/LITESPARK-029)

The purpose of this study is to assess the efficacy and safety of belzutifan (MK-6482) plus fulvestrant compared to everolimus plus endocrine therapy (ET) (investigator's choice of fulvestrant or exem...

120 participants
Merck Sharp & Dohme LLC
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RecruitingNewport Beach, CALIFORNIANCT04829604

ARX788 in HER2-positive, Metastatic Breast Cancer Subjects (ACE-Breast-03)

A Global, Phase 2 Study of ARX788 in HER2-positive Metastatic Breast Cancer Patients who were previously treated with T-DXd...

71 participants
Ambrx, Inc.
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RecruitingNewport Beach, CALIFORNIANCT06247995

A Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/6 Inhibitor.

In the phase I part, to determine the recommended doses (RD) and dosing regimens of \[177Lu\]Lu-NeoB in combination with capecitabine in adult patients with gastrin releasing peptide receptor positive...

58 participants
Novartis Pharmaceuticals
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RecruitingNewport Beach, CALIFORNIANCT04092673

Study of eFT226 in Subjects With Selected Advanced Solid Tumor Malignancies

This clinical trial is a Phase 1-2, open-label, sequential-group, dose-escalation and cohort-expansion study evaluating the safety, pharmacokinetics (PK), pharmacodynamics, and antitumor activity of Z...

30 participants
Effector Therapeutics
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About Breast Cancer Clinical Trials in Newport Beach

Breast cancer is a disease in which cells in the breast grow out of control. It is the most common cancer in women worldwide and can also occur in men. Treatment options include surgery, radiation, chemotherapy, hormone therapy, and targeted therapies.

There are currently 10 breast cancer clinical trials recruiting participants in Newport Beach, CALIFORNIA. These studies are seeking a combined 12,177 participants. Research is being sponsored by QuantumLeap Healthcare Collaborative, Stemline Therapeutics, Inc., Hoffmann-La Roche and 6 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Breast Cancer Clinical Trials in Newport Beach — FAQ

Are there breast cancer clinical trials in Newport Beach?

Yes, there are 10 breast cancer clinical trials currently recruiting in Newport Beach, CALIFORNIA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Newport Beach?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Newport Beach research site will contact you about next steps.

Are clinical trials in Newport Beach free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Newport Beach studies also compensate for your time and travel.

What breast cancer treatments are being tested?

The 10 active trials in Newport Beach are testing new therapies including novel drugs, biologics, and treatment approaches for breast cancer.

Data updated March 2, 2026 from ClinicalTrials.gov