Is NCT06428396 recruiting?

Yes, NCT06428396 is currently recruiting. This breast cancer study is enrolling participants at 14 locations.

What is the status of NCT06428396?

NCT06428396 is currently recruiting. This is a Clinical Trial trial for breast cancer sponsored by Merck Sharp & Dohme LLC. Status verified Dec 26, 2025 via ClinicalTrials.gov.

Where is NCT06428396 enrolling participants?

NCT06428396 has 14 active sites including Goodyear, Arizona; Beverly Hills, California; La Jolla, California and 11 more locations.

Who is eligible for NCT06428396?

This breast cancer trial is targeting 120 participants. Detailed eligibility criteria including age requirements and medical history are listed on this page.

Who can participate in this Breast Cancer study?

Eligibility varies by study, but generally includes adults diagnosed with Breast Cancer who meet specific medical criteria. Complete the interest form above to learn if you may qualify.

Is the study available in Goodyear, Arizona?

Yes! This study has active research sites in Goodyear, Beverly Hills, La Jolla. When you express interest, you'll be connected with the site nearest to you.

What are the benefits of joining a clinical trial for Breast Cancer?

Participants often receive: access to new treatments before they're widely available, close monitoring by medical professionals, study-related care at no cost, and the opportunity to contribute to medical research.

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NCT06428396 RECRUITINGIRB Ready

Study of Belzutifan (MK-6482) Plus Fulvestrant for ER+/HER2- Metastatic Breast Cancer (MK-6482-029/LITESPARK-029)

Express Your Interest Today

Interested in learning more? Complete the form below.

Why Participate?

No-Cost Study Care
Advance Medical Science
Contribute to groundbreaking research
Cutting-Edge Treatment
Access to innovative therapies
Expert Medical Care
Close monitoring by specialists
Possible Compensation*
For time and travel (varies by study)
Help Others
Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

1Submit this form
2Phone screening
3In-person assessment if eligible
4Begin participation

About This Study

The purpose of this study is to assess the efficacy and safety of belzutifan (MK-6482) plus fulvestrant compared to everolimus plus endocrine therapy (ET) (investigator's choice of fulvestrant or exemestane) in adults with estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+/HER2-) unresectable metastatic breast cancer. There is no formal hypothesis testing in this study.

Who Can Participate

Inclusion Criteria

Has a diagnosis of estrogen receptor positive (ER+)/human epidermal growth factor receptor negative (HER2-) invasive breast carcinoma that is either locally advanced disease not amenable to resection or metastatic disease not treatable with curative intent

Has documented radiographic confirmation of disease progression during or after the last administered endocrine therapy (ET)

Provides additional tissue from the same sample used to determine ER and HER2 status locally

Has received ET in the noncurative setting and has 1) Radiographic disease progression on 12 months or more of ET in combination with CDK4/6 inhibitor in the noncurative setting or 2) Received at least 2 lines of ET in the noncurative setting including CDK4/6 inhibitor where the CDK 4/6 inhibitor was discontinued due to intolerance

Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 assessed within 7 days of randomization

Participants who have AEs due to previou

❓ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

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Study Type

INTERVENTIONAL

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Target Enrollment

120 participants

⚧

Gender

ALL

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Sponsor

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

Express your interest in this groundbreaking clinical trial

🔒 Secure · 🏥 Expert Care

Find More Breast Cancer Trials by City

Browse all breast cancer clinical trials in these cities — not just this study.

Goodyear, Arizona Beverly Hills, California La Jolla, California Los Angeles, California Newport Beach, California Marietta, Georgia

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Looking for Breast Cancer Treatment in Goodyear?

Join others in Arizona exploring innovative treatment options through clinical research

Breast Cancer Treatment Options in Goodyear, Arizona

If you're searching for Breast Cancer treatment in Goodyear, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in Goodyear, Beverly Hills, La Jolla and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with Breast Cancer. All study-related care is provided at no cost to participants.

Local Sites

3 locations in Arizona

Now Enrolling

Up to 120 participants

Quick Start

Screening available now

Why Consider a Clinical Trial for Breast Cancer?

Potential Benefits

✓Access to new treatment approaches before public availability
✓Close monitoring by experienced medical professionals
✓Study-related care provided at no cost
✓Contribute to medical research for Breast Cancer

What to Expect

→Initial screening to determine eligibility
→Regular check-ups and monitoring visits
→Possible compensation for time and travel
→You can withdraw at any time

Frequently Asked Questions About This Breast Cancer Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT06428396. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.