9 Bipolar Disorder Clinical Trials in Orange, MA (2026)

Q: How do I join a clinical trial in Orange?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Orange research site will contact you.

Recruiting Bipolar Disorder Studies in Orange

NCT07140913Recruiting

A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine

The purpose of this study is to evaluate the efficacy and safety of adjunctive KarXT for the treatment of mania in participants with Bipolar-I Disorder....

Orange, MA424 participantsBristol-Myers Squibb

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NCT07286175Recruiting

A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)

The purpose of this study is to assess the efficacy and safety of brenipatide when administered with standard of care (SoC), compared with placebo plus SoC in delaying the worsening of bipolar disorde...

Orange, MA400 participantsEli Lilly and Company

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NCT07172516Recruiting

A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)

X-CEED is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of azetukalner in adult participants diagnosed with bipolar I or II disorder wh...

Orange, MA400 participantsXenon Pharmaceuticals Inc.

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NCT04777357Recruiting

A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.

Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States. The treatment of the depressive episodes of ...

Orange, MA380 participantsAbbVie

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NCT06462612Recruiting

Study of Lumateperone in the Treatment of Patients With Bipolar Mania

This is a multicenter, randomized, double-blind, placebo-controlled, study in the acute treatment of patients with a diagnosis of bipolar I disorder with manic episodes or manic episodes with mixed fe...

Orange, MA350 participantsIntra-Cellular Therapies, Inc.

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NCT07494305Recruiting

Multicenter Study to Assess the Efficacy and Safety of LB-102 in the Treatment of Adult Patients With BP1MDE.

Phase II study for patients with Bipolar 1 Disorder experiencing major depressive episode. Patient eligible for enrollment will be randomized (like flipping a coin) to either active drug (LB-102 or pl...

Orange, MA320 participantsLB Pharmaceuticals Inc.

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NCT06951698Recruiting

A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder

The purpose of this study is to evaluate the efficacy and safety of KarXT for the treatment of manic episodes in Bipolar-I Disorder...

Orange, MA274 participantsBristol-Myers Squibb

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NCT07046494Recruiting

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Bipolar I Disorder

This is a clinical research study for an investigational drug called RAP-219 in participants with bipolar I disorder. This study is being conducted to determine if RAP-219 is safe and effective in par...

Orange, MA250 participantsRapport Therapeutics Inc.

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NCT06696755Recruiting

A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder

Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States. This study will assess how safe and effectiv...

Orange, MA195 participantsAbbVie

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About Bipolar Disorder Clinical Trials in Orange

Bipolar disorder is a mental health condition marked by extreme mood swings including emotional highs (mania or hypomania) and lows (depression). It affects about 2.8% of adults in the U.S. Treatment typically involves mood stabilizers, antipsychotics, and psychotherapy.

There are currently 9 bipolar disorder clinical trials recruiting participants in Orange, MA. These studies are seeking a combined 2,993 participants. Research is being sponsored by Bristol-Myers Squibb, Eli Lilly and Company, Xenon Pharmaceuticals Inc. and 4 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Bipolar Disorder Clinical Trials in Orange — FAQ

Are there bipolar disorder clinical trials in Orange?

Yes, there are 9 bipolar disorder clinical trials currently recruiting in Orange, MA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Orange?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Orange research site will contact you about next steps.

Are clinical trials in Orange free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Orange studies also compensate for your time and travel.

What bipolar disorder treatments are being tested?

The 9 active trials in Orange are testing new therapies including novel drugs, biologics, and treatment approaches for bipolar disorder.

Data updated July 13, 2026 from ClinicalTrials.gov