8 Melanoma Clinical Trials in Orange, NJ (2026)

Q: How do I join a clinical trial in Orange?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Orange research site will contact you.

Recruiting Melanoma Studies in Orange

NCT03860883Recruiting

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. Thi...

Orange, NJ2,998 participantsMelanoma and Skin Cancer Trials Limited

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NCT06246916Recruiting

A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

This study is researching an experimental drug called fianlimab (also known as REGN3767), combined with another medication called cemiplimab (also known as REGN2810), called "study drugs". The study i...

Orange, NJ560 participantsRegeneron Pharmaceuticals

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NCT07015190Recruiting

Neoadjuvant Darovasertib in Primary Uveal Melanoma

This is a Phase 3, randomized, multi-center, open-label study of neoadjuvant darovasertib in subjects with primary non-metastatic uveal melanoma (OptimUM-10)...

Orange, NJ520 participantsIDEAYA Biosciences

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NCT06264180Recruiting

VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]

This is a randomized, controlled, multicenter, open-label Phase 3 clinical study comparing VO in combination with nivolumab versus Physician's Choice treatment for patients with unresectable Stage III...

Orange, NJ400 participantsReplimune Inc.

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NCT05655312Recruiting

MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

In this first-in human, phase I/IIa study, the safety and efficacy of \[212Pb\]VMT01, an alpha-particle emitting therapeutic agent targeted to melanocortin sub-type 1 receptor (MC1R) is being evaluate...

Orange, NJ300 participantsPerspective Therapeutics

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NCT03567889Recruiting

Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C Melanoma Patients

The trial aims to evaluate the efficacy of Daromun neoadjuvant treatment followed by surgery and adjuvant therapy to improve in a statistically significant manner the recurrence-free survival (RFS) of...

Orange, NJ186 participantsPhilogen S.p.A.

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NCT05136196Recruiting

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

This phase II trial studies the good and bad effects of the combination of drugs called cabozantinib and nivolumab in treating patients with melanoma or squamous cell head and neck cancer that may hav...

Orange, NJ150 participantsNational Cancer Institute (NCI)

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NCT06771544Recruiting

Metronomic Cyclophosphamide With Pembrolizumab in Checkpoint Inhibitor Refractory Melanoma

This is a phase 2, single-arm, open label clinical trial determining efficacy of Cyclophosphamide and Pembrolizumab in subjects with melanoma....

Orange, NJ14 participantsUniversity of California, Irvine

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About Melanoma Clinical Trials in Orange

Melanoma is the most serious type of skin cancer, developing from the pigment-producing cells known as melanocytes. While less common than other skin cancers, melanoma is more likely to spread. Immunotherapy and targeted therapy have revolutionized melanoma treatment.

There are currently 8 melanoma clinical trials recruiting participants in Orange, NJ. These studies are seeking a combined 5,128 participants. Research is being sponsored by Melanoma and Skin Cancer Trials Limited, Regeneron Pharmaceuticals, IDEAYA Biosciences and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Melanoma Clinical Trials in Orange — FAQ

Are there melanoma clinical trials in Orange?

Yes, there are 8 melanoma clinical trials currently recruiting in Orange, NJ. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Orange?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Orange research site will contact you about next steps.

Are clinical trials in Orange free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Orange studies also compensate for your time and travel.

What melanoma treatments are being tested?

The 8 active trials in Orange are testing new therapies including novel drugs, biologics, and treatment approaches for melanoma.

Data updated July 13, 2026 from ClinicalTrials.gov