6 Major Depressive Disorder Clinical Trials in Orlando, FL (2026)

Q: How do I join a clinical trial in Orlando?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Orlando research site will contact you.

Recruiting Major Depressive Disorder Studies in Orlando

NCT07196501Recruiting

A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

The primary objective of this study is to evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in delaying relapse of depressive symptoms (maintenance of effect) in pa...

Orlando, FLPHASE3550 participantsNeurocrine Biosciences

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NCT07065240Recruiting

A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

This is a randomized, parallel-group, double-blind, placebo-controlled, monotherapy study to evaluate the efficacy, safety, and tolerability of SPT-300 (GlyphAllo) in adults with major depressive diso...

Orlando, FLPHASE2360 participantsSeaport Therapeutics

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NCT07300969Recruiting

A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

The goal of this clinical trial is to learn if DT-101 can treat depression in adults. The effect of DT-101 will be compared to placebo. Subjects will attend the clinic every couple of weeks complete g...

Orlando, FLPHASE2300 participantsDraig Therapeutics Ltd

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NCT07592689Recruiting

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Ascend...

Orlando, FLPHASE3165 participantsDefinium Therapeutics US, Inc.

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NCT07610473Recruiting

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

In this study, researchers will learn more about a study drug called DT-101 in participants with Major Depressive Disorder (MDD), a form of depression. The goal of this clinical trial is to learn if D...

Orlando, FLPHASE2118 participantsDraig Therapeutics Ltd

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NCT05877885Recruiting

Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics

The goal of this randomized controlled trial is to evaluate the potential of a customized digital cognitive training intervention to target aspects of brain function in apathy of late-life depression ...

Orlando, FLNA84 participantsAdventHealth

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About Major Depressive Disorder Clinical Trials in Orlando

Major depressive disorder (MDD) is a severe form of depression characterized by persistent sadness, loss of interest, and impaired daily functioning. Treatment-resistant depression (TRD) affects patients who do not respond to standard therapies. Novel treatments like ketamine, psilocybin, and neuromodulation are being studied.

There are currently 6 major depressive disorder clinical trials recruiting participants in Orlando, FL. These studies are seeking a combined 1,577 participants. Research is being sponsored by Neurocrine Biosciences, Seaport Therapeutics, Draig Therapeutics Ltd and 2 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Major Depressive Disorder Clinical Trials in Orlando — FAQ

Are there major depressive disorder clinical trials in Orlando?

Yes, there are 6 major depressive disorder clinical trials currently recruiting in Orlando, FL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Orlando?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Orlando research site will contact you about next steps.

Are clinical trials in Orlando free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Orlando studies also compensate for your time and travel.

What major depressive disorder treatments are being tested?

The 6 active trials in Orlando are testing new therapies including novel drugs, biologics, and treatment approaches for major depressive disorder.

Data updated October 18, 2026 from ClinicalTrials.gov