7 Melanoma Clinical Trials in Palo Alto, CA (2026)

Q: How do I join a clinical trial in Palo Alto?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Palo Alto research site will contact you.

Recruiting Melanoma Studies in Palo Alto

NCT03860883Recruiting

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. Thi...

Palo Alto, CANA2,998 participantsMelanoma and Skin Cancer Trials Limited

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NCT06112314Recruiting

IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)

This is a phase 3, randomized, controlled study of brenetafusp (IMC-F106C) plus nivolumab compared to standard nivolumab regimens in HLA-A\*02:01-positive participants with previously untreated advanc...

Palo Alto, CAPHASE3680 participantsImmunocore Ltd

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NCT07015190Recruiting

Neoadjuvant Darovasertib in Primary Uveal Melanoma

This is a Phase 3, randomized, multi-center, open-label study of neoadjuvant darovasertib in subjects with primary non-metastatic uveal melanoma (OptimUM-10)...

Palo Alto, CAPHASE3520 participantsIDEAYA Biosciences

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NCT06264180Recruiting

VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]

This is a randomized, controlled, multicenter, open-label Phase 3 clinical study comparing VO in combination with nivolumab versus Physician's Choice treatment for patients with unresectable Stage III...

Palo Alto, CAPHASE3400 participantsReplimune Inc.

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NCT06581406Recruiting

A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

The purpose of this study is to measure the clinical benefits of the combination of RP2 and nivolumab as compared with the combination of nivolumab and ipilimumab in patients with metastatic uveal mel...

Palo Alto, CAPHASE2280 participantsReplimune Inc.

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NCT06007690Recruiting

A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma

The primary objective is to determine the safety and efficacy of belzupacap sarotalocan (bel-sar) compared to sham control in patients with primary indeterminate lesions (IL) or small choroidal melano...

Palo Alto, CAPHASE3100 participantsAura Biosciences

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NCT06712927Recruiting

Trial of Relatlimab, Nivolumab, and Ipilimumab in Patients With Asymptomatic and Symptomatic Melanoma Brain Metastases

This is a multicenter, phase II trial of relatlimab (rela), nivolumab (nivo), and ipilimumab (ipi) in patients with asymptomatic and symptomatic melanoma brain metastases....

Palo Alto, CAPHASE260 participantsStanford University

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About Melanoma Clinical Trials in Palo Alto

Melanoma is the most serious type of skin cancer, developing from the pigment-producing cells known as melanocytes. While less common than other skin cancers, melanoma is more likely to spread. Immunotherapy and targeted therapy have revolutionized melanoma treatment.

There are currently 7 melanoma clinical trials recruiting participants in Palo Alto, CA. These studies are seeking a combined 5,038 participants. Research is being sponsored by Melanoma and Skin Cancer Trials Limited, Immunocore Ltd, IDEAYA Biosciences and 3 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Melanoma Clinical Trials in Palo Alto — FAQ

Are there melanoma clinical trials in Palo Alto?

Yes, there are 7 melanoma clinical trials currently recruiting in Palo Alto, CA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Palo Alto?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Palo Alto research site will contact you about next steps.

Are clinical trials in Palo Alto free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Palo Alto studies also compensate for your time and travel.

What melanoma treatments are being tested?

The 7 active trials in Palo Alto are testing new therapies including novel drugs, biologics, and treatment approaches for melanoma.

Data updated July 17, 2026 from ClinicalTrials.gov