13 Sleep Apnea Clinical Trials in Philadelphia, PA (2026)

Q: How do I join a clinical trial in Philadelphia?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you.

Recruiting Sleep Apnea Studies in Philadelphia

NCT03487185Recruiting

Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

A randomized controlled trial of 1,500 women to assess whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a reduction in the rate ...

Philadelphia, PANA1,500 participantsThe George Washington University Biostatistics Center

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NCT06189755Recruiting

MicroRNAs as Biomarkers for Obstructive Sleep Apnea

Although obstructive sleep apnea (OSA) is a common disorder, there are no blood biomarkers for identification and management of these patients. This project will study microRNAs in order to develop an...

Philadelphia, PA500 participantsUniversity of Pennsylvania

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NCT05382754Recruiting

Home Apnea Testing in CHildren Trial

This clinical trial will compare home sleep apnea testing with the gold standard in-lab polysomnography in terms of 1) accuracy, 2) therapeutic decision-making, and 3) parent/child acceptability in ch...

Philadelphia, PANA317 participantsChildren's Hospital of Philadelphia

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NCT05050383Recruiting

DISE: Phenotyping Obstruction Patterns

Drug-induced sleep endoscopy (DISE) represents an opportunity to evaluate the upper airway in sleep-like conditions. In its current clinical form, however, DISE does not routinely determine the functi...

Philadelphia, PANA241 participantsUniversity of Pennsylvania

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NCT06043440Recruiting

Down Syndrome Obstructive Sleep Apnea

The purpose of this study is to assess whether oxygen supplementation during sleep improves working memory and other clinical and patient-reported outcomes among children who have Down Syndrome (DS) w...

Philadelphia, PAPHASE2230 participantsBrigham and Women's Hospital

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NCT05742360Recruiting

Effect of CPAP on Blood Pressure in Excessively Sleepy Obstructive Sleep Apnea Subtype

The primary objective of this study is to determine the longer-term (6 months) effect of CPAP therapy on change in 24-hour mean blood pressure (24hMBP) in OSA subjects with the excessively sleepy symp...

Philadelphia, PA227 participantsOhio State University

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NCT07280468Recruiting

Endotype DIrected Treatment for OSA in Down Syndrome

Down syndrome is the most common genetic cause of intellectual disability. People with Down syndrome often have obstructive sleep apnea (OSA), a condition where people have difficulties with breathing...

Philadelphia, PAPHASE4200 participantsUniversity of Arizona

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NCT04457154Recruiting

Pediatric Post-Approval Registry

This registry is a prospective, multi-center, single-arm study of pediatric subjects (ages 18-21 years) who are undergoing implant of the Inspire Upper Airway Stimulation (UAS) System for the treatmen...

Philadelphia, PA60 participantsInspire Medical Systems, Inc.

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NCT06789445Recruiting

A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)

Study OpCT-001-101 is a Phase 1/2a first-in-human, multisite, 2-part interventional study to evaluate the safety, tolerability, and the effect on clinical outcomes of OpCT-001 in up to approximately 5...

Philadelphia, PAPHASE154 participantsBlueRock Therapeutics

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NCT06436846Recruiting

Genomic Risk in Retroperitoneal Sarcoma

The protocol intends to explore the biology which may underlie recurrences of retroperitoneal liposarcoma. Surgery remains the only curative intent intervention for this disease. Often, tumors recur i...

Philadelphia, PA50 participantsFox Chase Cancer Center

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NCT06789770Recruiting

Nasal vs Oral Breathing in Drug Induced Sleep vs Natural Sleep

This project will provide important new information regarding (1) the relationship between route of breathing and airway collapsibility and (2) whether route of breathing during DISE (Drug-Induced Sle...

Philadelphia, PA50 participantsUniversity of Pennsylvania

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NCT06008626Recruiting

Clinical Trial of the Cryosa System for the Treatment of Obstructive Sleep Apnea

This is a prospective, multicenter, non-randomized single-arm safety and performance study to collect data to evaluate the safety of the Cryosa procedure to treat obstructive sleep apnea (OSA) in pati...

Philadelphia, PANA25 participantsCryosa, Inc.

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NCT04173650Recruiting

MSC EVs in Dystrophic Epidermolysis Bullosa

INVESTIGATIONAL PRODUCT: AGLE-102 is an allogeneic extracellular vesicle (EV) product derived from normal donor mesenchymal stem cells (MSCs). INDICATION AND RATIONALE: The aim of the study is to ass...

Philadelphia, PAPHASE18 participantsAegle Therapeutics

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About Sleep Apnea Clinical Trials in Philadelphia

Sleep apnea is a potentially serious sleep disorder in which breathing repeatedly stops and starts during sleep. Obstructive sleep apnea (OSA) is the most common form. Treatment includes CPAP therapy, oral appliances, lifestyle changes, and in some cases surgery.

There are currently 13 sleep apnea clinical trials recruiting participants in Philadelphia, PA. These studies are seeking a combined 3,462 participants. Research is being sponsored by The George Washington University Biostatistics Center, University of Pennsylvania, Children's Hospital of Philadelphia and 8 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Sleep Apnea Clinical Trials in Philadelphia — FAQ

Are there sleep apnea clinical trials in Philadelphia?

Yes, there are 13 sleep apnea clinical trials currently recruiting in Philadelphia, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Philadelphia?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you about next steps.

Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Philadelphia studies also compensate for your time and travel.

What sleep apnea treatments are being tested?

The 13 active trials in Philadelphia are testing new therapies including novel drugs, biologics, and treatment approaches for sleep apnea.

Data updated July 17, 2026 from ClinicalTrials.gov