25 Heart Attack Clinical Trials in Pittsburgh, PA (2026)

Q: How do I join a clinical trial in Pittsburgh?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Pittsburgh research site will contact you.

Recruiting Heart Attack Studies in Pittsburgh

NCT00001373Recruiting

Familial Mediterranean Fever and Related Disorders: Genetics and Disease Characteristics

This study is designed to explore the genetics and pathophysiology of diseases presenting with intermittent fever, including familial Mediterranean fever, TRAPS, hyper-IgD syndrome, and related diseas...

Pittsburgh, PA5,000 participantsNational Human Genome Research Institute (NHGRI)

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NCT00078078Recruiting

Clinical and Laboratory Study of Methylmalonic Acidemia

Methylmalonic acidemia (MMA), one of the most common inborn errors of organic acid metabolism, is heterogeneous in etiology and clinical manifestations. Affected patients with cblA, cblB and mut class...

Pittsburgh, PA2,275 participantsNational Human Genome Research Institute (NHGRI)

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NCT06661291Recruiting

Pip Care to Improve Surgical Patient Outcomes

Pip Care is developing a personalized, interactive surgical journey platform with a live health coach that works directly with health systems to optimize the perioperative care process. Our Health Ins...

Pittsburgh, PANA1,300 participantsUniversity of Pittsburgh

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NCT05983757Recruiting

Combined Thrombectomy for Distal MediUm Vessel Occlusion StroKe

A phase III, randomized, multi-center, investigational, open label clinical trial that will examine whether treatment with endovascular thrombectomy is superior to standard medical therapy alone in pa...

Pittsburgh, PANA584 participantsRaul Nogueira

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NCT05933083Recruiting

MCNAIR Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac Rehabilitation

Cardiac rehabilitation is a medically recommended program for patients with certain heart conditions. It includes exercise training, health education, and counseling. Unfortunately, many patients do n...

Pittsburgh, PANA516 participantsUniversity of California, San Francisco

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NCT06351631Recruiting

A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)

The primary purpose of the study is to transition participants into an extension study to collect long-term safety and efficacy data. The study will include participants who are safely tolerating bome...

Pittsburgh, PAPHASE3400 participantsMerck Sharp & Dohme LLC

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NCT06396247Recruiting

Impact of Brief Daily Functional Resistance Training on Lower Extremity Physical Performance

In this study, we will randomly assign 360 older adults to 12 months of 5 minutes per day of functional resistance training or to a delayed treatment control condition, and measure the impact of the t...

Pittsburgh, PAPHASE2360 participantsMilton S. Hershey Medical Center

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NCT06370182Recruiting

Safety and Effectiveness of Mechanical Thrombectomy Using the Anaconda ANA Funnel Catheter

The objective of this study is to assess the safety and effectiveness of mechanical thrombectomy (MT) using the ANA funnel catheter in its intended use, which is to facilitate the navigation and deplo...

Pittsburgh, PANA327 participantsAnaconda Biomed S.L.

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NCT06819904Recruiting

Acceptance and Commitment Therapy Integrated Vestibular Rehabilitation (ACTIVE) RCT

The primary objective of this multi-site randomized clinical trial (RCT) is to compare Acceptance and Commitment Therapy Integrated Rehabilitation (ACT) with usual care rehabilitation (CONTROL) in 250...

Pittsburgh, PANA250 participantsUniversity of Pittsburgh

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NCT05475925Recruiting

A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas

This is a multicenter, first-in-human, Phase 1/2 study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and anti-tumor activity of DR-01 in adult patients with large granular ...

Pittsburgh, PAPHASE1200 participantsDren Bio

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NCT05073419Recruiting

Arrhythmia Detection After MI

Patients post acute myocardial infarction (AMI) have a high risk of mortality but the use of an implantable defibrillator in the early aftermath of an AMI has not been shown to improve patients' survi...

Pittsburgh, PANA200 participantsSamir Saba

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NCT06675344Recruiting

The Apollo Device in Systemic Sclerosis for the Management of fatiguE, Raynaud Phenomenon and qualiTy of Life

The purpose of this study it to test the efficacy of a wearable device to improve symptom management and maximize qualify of life in systemic Sclerosis (SSc) patients in a randomized trial. Specifical...

Pittsburgh, PANA160 participantsRobyn T. Domsic, MD, MPH

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NCT03970096Recruiting

Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)

This phase II trial investigates two strategies and how well they work for the reduction of graft versus host disease in patients with acute leukemia or MDS in remission. Giving chemotherapy and total...

Pittsburgh, PAPHASE2120 participantsFred Hutchinson Cancer Center

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NCT07271667Recruiting

A Study of Emavusertib + An Approved Bruton Tyrosine Kinase Inhibitor (BTKi) in Participants With Chronic Lymphocytic Leukemia (CLL) and Other B-cell Malignancies

The primary objective of the study for Cohort 1 and Cohort 2 is to assess the anticancer activity of emavusertib in combination with zanubrutinib in participants with CLL....

Pittsburgh, PAPHASE2108 participantsCuris, Inc.

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NCT07037771Recruiting

A Phase 3 Study of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial Hypercholesterolemia (YOSEMITE)

This multicenter, randomized, placebo-controlled study will evaluate the efficacy and safety of zodasiran subcutaneous (SC) injection in subjects 12 years of age and older with genetically or clinical...

Pittsburgh, PAPHASE360 participantsArrowhead Pharmaceuticals

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NCT07012044Recruiting

A Study to Find the Highest Dose of Cedazuridine and Decitabine Combination With Filgrastim as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With High-Risk Acute Myeloid Leukemia

This phase I trial tests the safety, side effects, and best dose of ASTX727 and filgrastim for the treatment of children with high risk acute myeloid leukemia that has come back after a period of impr...

Pittsburgh, PAPHASE147 participantsNational Cancer Institute (NCI)

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NCT06529731Recruiting

Interferon-γ (IFN-γ) With Donor Leukocyte Infusion to Treat Relapsed Acute Myeloid Leukemia and Myelodysplastic Syndromes Post Allogeneic Hematopoietic Stem Cell Transplantation

This phase 2 study aims to confirm the efficacy seen in the prior phase 1 trial, and further contribute to this effort through the collection of leukemia cells pre- and post- in vivo IFN-γ therapy. As...

Pittsburgh, PAPHASE245 participantsSawa Ito, MD

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NCT06654037Recruiting

Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal Cancer

This phase I trial tests the safety, side effects, and best dose of abemaciclib in combination with 5-fluorouracil and how well it works in treating patients with colorectal cancer that has spread fro...

Pittsburgh, PAPHASE139 participantsNational Cancer Institute (NCI)

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NCT06666439Recruiting

Longitudinal Tumor Burden Quantification Using Circulating Tumor DNA in Metastatic Lobular Breast Cancer

The goal of this study is to characterize early dynamic changes in ctDNA, which can aid in tailoring early therapy in patients with metastatic Invasive lobular carcinoma (ILC). Response assessment usi...

Pittsburgh, PA20 participantsJulia Foldi

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NCT06672822Recruiting

Intralesional Injection of STS in Treatment of Calcinosis

The specific objective of this study is to perform a small, open-label study to assess the safety and efficacy of intralesional, subcutaneous injection of STS on calcinosis symptoms and lesion size in...

Pittsburgh, PAPHASE220 participantsRobyn T. Domsic, MD, MPH

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NCT07061951Recruiting

Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia

This phase II trial tests the effect of mirdametinib in treating patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back after a period of improvement (...

Pittsburgh, PAPHASE220 participantsNational Cancer Institute (NCI)

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NCT06355895Recruiting

Liver Volume Variation Effect on SBRT Planning and Delivery for Upper Abdominal Malignancies

Standard planning constraints for liver SBRT incorporate strict dose-volume limits for normal liver parenchyma to minimize the risk of radiation-induced liver disease. The presence of diurnal and fast...

Pittsburgh, PANA17 participantsUniversity of Pittsburgh

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NCT07330778Recruiting

A Study of CDX-622 in Participants With Mild to Moderate Asthma

This is a study to determine the safety, pharmacodynamics (PD), and pharmacokinetics (PK) of CDX-622 in adults with mild to moderate asthma....

Pittsburgh, PAPHASE112 participantsCelldex Therapeutics

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NCT07583251Recruiting

Safety And Tolerability Of Gamma Glutamylcysteine (GGC) Oral Supplementation In MCI Patients

The goal of this study is to evaluate the safety and tolerability of Gamma Glutamylcysteine (GGC) supplement at different doses (400mg/day or 800mg/day or 1200mg/day) when administered orally to patie...

Pittsburgh, PAPHASE19 participantsPravat Mandal

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NCT03630211Recruiting

Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis

The purpose of this study is to determine whether a regimen of high-dose immunoablative therapy will demonstrate safety that is consistent or improved with other published regimens in SSc patients, wh...

Pittsburgh, PAPHASE28 participantsPaul Szabolcs

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About Heart Attack Clinical Trials in Pittsburgh

A heart attack (myocardial infarction) occurs when blood flow to part of the heart muscle is blocked, usually by a blood clot. It is a medical emergency requiring immediate treatment. Long-term management includes medications, lifestyle changes, and cardiac rehabilitation.

There are currently 25 heart attack clinical trials recruiting participants in Pittsburgh, PA. These studies are seeking a combined 12,097 participants. Research is being sponsored by National Human Genome Research Institute (NHGRI), University of Pittsburgh, Raul Nogueira and 16 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Heart Attack Clinical Trials in Pittsburgh — FAQ

Are there heart attack clinical trials in Pittsburgh?

Yes, there are 25 heart attack clinical trials currently recruiting in Pittsburgh, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Pittsburgh?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Pittsburgh research site will contact you about next steps.

Are clinical trials in Pittsburgh free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Pittsburgh studies also compensate for your time and travel.

What heart attack treatments are being tested?

The 25 active trials in Pittsburgh are testing new therapies including novel drugs, biologics, and treatment approaches for heart attack.

Data updated July 19, 2026 from ClinicalTrials.gov