NCT06355895 · University of Pittsburgh
Liver Volume Variation Effect on SBRT Planning and Delivery for Upper Abdominal Malignancies
What this study is about
Standard planning constraints for liver SBRT incorporate strict dose-volume limits for normal liver parenchyma to minimize the risk of radiation-induced liver disease.
View original scientific description
Standard planning constraints for liver SBRT incorporate strict dose-volume limits for normal liver parenchyma to minimize the risk of radiation-induced liver disease. The presence of diurnal and fasting/fed variations in liver volume therefore carry substantial potential for introducing errors into estimates of dose-volume distribution within normal liver tissue, as well as affecting day-to-day setup fidelity and organ alignment for treatment. This prospective study will examine how diurnal and fast-fed variations in liver volume affect treatment planning for abdominal SBRT.
Interventions
DIETARY_SUPPLEMENT
Standardized high-carbohydrate meal
8 ounces of Ensure® nutritional protein shake or a similar meal
Primary outcome measures
Diurnal Difference in Liver Volumes
Time frame: At baseline and at 4 hours post intervention
Percentage diurnal difference in total liver volumes (change in liver volume), as measured by Stereotactic Body Radiation Therapy (SBRT) planning software.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- • Have primary upper abdominal (pancreatic, bile duct, liver) cancer or upper abdominal metastases (liver, adrenal, upper abdominal lymph nodes) planned to undergo SBRT.
Exclusion criteria
- Had prior Radiation Therapy to the liver
- Contraindication to receipt of iodinated IV contrast for CT (such as renal insufficiency or allergy that cannot be overcome by premedication)
- Pregnancy/lactation OR woman of childbearing potential who is unable or unwilling to use adequate contraception during Radiation Therapy.
- Inability to fast.
Where
- Pittsburgh, Pennsylvania
Collaborators
American College of Radiation Oncology
Related conditions & keywords
Frequently asked questions
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Data: ClinicalTrials.gov · synced Jun 11, 2026 · Source of record for eligibility and locations