25 Brain Cancer Clinical Trials in Rochester, MI (2026)

Q: How do I join a clinical trial in Rochester?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Rochester research site will contact you.

Recruiting Brain Cancer Studies in Rochester

NCT05366881Recruiting

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers inc...

Rochester, MI7,000 participantsAdela, Inc

View Study Details

NCT02977780Recruiting

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

This research study is studying several investigational drugs as a possible treatment for Glioblastoma (GBM). The drugs involved in this study are : * Abemaciclib * Temozolomide (temodar) * Neratini...

Rochester, MI460 participantsPatrick Wen, MD

View Study Details

NCT03750227Recruiting

Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

This phase III trial studies the side effects and how well stereotactic radiosurgery (SRS) works before or after surgery in patients with tumors that has spread to the brain or that can be removed by ...

Rochester, MI140 participantsMayo Clinic

View Study Details

NCT06160206Recruiting

Retifanlimab with Bevacizumab and Hypofractionated Radiotherapy for the Treatment of Recurrent Glioblastoma

This phase II trial tests how well retifanlimab with bevacizumab and hypofractionated radiotherapy, compared to bevacizumab and hypofractionated radiotherapy alone, works in treating patients with gli...

Rochester, MI134 participantsAcademic and Community Cancer Research United

View Study Details

NCT07074756Recruiting

A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma

This clinical trial tests how well a digital treatment platform using a mobile application works for the delivery of home-based sequential therapy in patients with glioma. Access to specialized neuro-...

Rochester, MI120 participantsMayo Clinic

View Study Details

NCT07091864Recruiting

Continuous Glucose Monitoring for the Management of Hyperglycemia in Patients With Glioblastoma

This clinical trial studies whether continuous glucose monitoring (CGM) can be used to help patients with glioblastoma manage their blood sugar (glucose) levels and improve survival. Glioblastoma is t...

Rochester, MI116 participantsMayo Clinic

View Study Details

NCT07225621Recruiting

Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

The purpose of this research is to test an investigational device using ultrasound along with an investigational drug to see if it is useful in treating glioblastoma following standard of care therapy...

Rochester, MI103 participantsAlpheus Medical, Inc.

View Study Details

NCT04692337Recruiting

Ommaya Reservoir Placement for Brain Tumor Biomarker Access

The purpose of this study is to determine the safety and feasibility of intra-operative Ommaya Reservoir placement during a clinically indicated operation for brain tumor. The Ommaya reservoir will fa...

Rochester, MI100 participantsMayo Clinic

View Study Details

NCT04047264Recruiting

Feasibility of Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies

This clinical trial evaluates the use of microdialysis catheters during surgery to collect biomarkers, and studies the feasibility of intraoperative microdialysis during neurosurgery for central nervo...

Rochester, MI100 participantsMayo Clinic

View Study Details

NCT05917145Recruiting

ATM-Inhibitor WSD0628 in Combination With Radiation Therapy for Treatment of Recurrent High-Grade Glioma

The purpose of this study is to test WSD0628 in combination with radiation therapy for recurrent brain tumors....

Rochester, MI94 participantsMayo Clinic

View Study Details

NCT07282587Recruiting

Study of ONC206 (JZP3507) in Advanced Pheochromocytoma and Paraganglioma

This is a two-stage Phase 2 trial evaluating the efficacy and safety of ONC206 in participants with Pheochromocytoma and Paraganglioma (PCPG)....

Rochester, MI90 participantsJazz Pharmaceuticals

View Study Details

NCT05222620Recruiting

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

This phase II trial compares the effect of single fraction stereotactic radiosurgery to fractionated stereotactic radiosurgery for the treatment of patients with cancer that has spread to the brain (m...

Rochester, MI90 participantsMayo Clinic

View Study Details

NCT04065776Recruiting

Evaluation of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma

Low-grade gliomas (LGGs) are the most common brain tumors in children, and a subset of these tumors are treated definitively with focal radiation therapy (RT). These patients often survive for many ye...

Rochester, MI74 participantsSt. Jude Children's Research Hospital

View Study Details

NCT06482905Recruiting

Safety and Efficacy Study of TX103 CAR-T Cell Therapy for Recurrent or Progressive Grade 4 Glioma.

This is a phase I, open-Label, single/multiple dose, dose-escalation study to evaluate the safety, tolerability and antitumor activity of anti-B7-H3 CAR-T cell injection (TX103) in subjects with recur...

Rochester, MI52 participantsTcelltech Inc.

View Study Details

NCT04543201Recruiting

Telehealth Visits to Discuss Advanced Directives for Patients Newly Diagnosed With High Grade Glioma

High grade gliomas (HGGs) are rapidly progressive brain tumors resulting in death for most patients between 6 months and 2 years after diagnosis. It is important for patients with HGG to discuss and d...

Rochester, MI50 participantsUniversity of Rochester

View Study Details

NCT07185880Recruiting

A Phase 1/2 Study of the Safety and Tolerability of MT-125 in GBM Patients

The purpose of the study is to determine the recommended dose and further understand the safety of MT-125 in participants who have been diagnosed with glioblastoma, a primary brain tumor, when adminis...

Rochester, MI36 participantsMyosin Therapeutics Inc.

View Study Details

NCT07301268Recruiting

GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma

This phase II trial compares the effect of GI-102 alone and in combination with pembrolizumab given before surgery in treating patients with IDH wildtype glioblastoma and IDH mutated grade 4 astrocyto...

Rochester, MI36 participantsMayo Clinic

View Study Details

NCT07468136Recruiting

Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas

This phase I/II trial tests the safety, side effects best dose and effect of retifanlimab with or without difluoromethylornithine (DFMO) for the treatment of high grade gliomas that are growing, sprea...

Rochester, MI33 participantsMayo Clinic

View Study Details

NCT06011109Recruiting

Treatment of Patients With Recurrent High-Grade Glioma With APG-157 and Bevacizumab

The goal of this interventional study is to evaluate the efficacy of APG-157 in combination with Bevacizumab in subjects with recurrent high-grade glioma. The main questions the study aims to answer a...

Rochester, MI30 participantsAveta Biomics, Inc.

View Study Details

NCT07025226Recruiting

Medication Combinations of Dasatinib, Quercetin, Fisetin, Temozolomide, LMP744, and Autologous TLPO Vaccine for the Treatment of Previously Treated Glioma With Residual Disease

This early phase I trial tests the safety, side effects and how well medication combinations of dasatinib, quercetin, fisetin, temozolomide, LMP744, and autologous tumor lysate particle only (TLPO) va...

Rochester, MI30 participantsMayo Clinic

View Study Details

NCT05077735Recruiting

Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study

This phase II trial studies the clinical outcomes of hypofractionated radiation therapy in patients with diffuse midline gliomas. This study aims to change the way radiation is delivered, from giving ...

Rochester, MI29 participantsMayo Clinic

View Study Details

NCT06444412Recruiting

An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients With Glioma

This clinical trial evaluates whether gallium-68 (Ga-68) prostate specific membrane antigen (PSMA)-11 positron emission tomography (PET)/computed tomography (CT) imaging is useful in differentiating b...

Rochester, MI25 participantsMayo Clinic

View Study Details

NCT05717153Recruiting

Intratumoral Extracellular Metabolic Impact of DFMO and AMXT 1501 in Patients With Diffuse or High Grade Glioma

This early phase I trial studies brain tumor (glioma) metabolism in response to eflornithine (DFMO) and polyamine transport inhibitor AMXT-1501 dicaprate (AMXT 1501) in patients with diffused or high ...

Rochester, MI18 participantsMayo Clinic

View Study Details

NCT07076472Recruiting

Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma

This early phase I trial tests the safety, best dose, and effectiveness of SONALA-001 or 5-ALA HCL in combination with magnetic resonance imaging-guided focused ultrasound (MRgFUS), also called sonody...

Rochester, MI8 participantsMayo Clinic

View Study Details

NCT05733312Recruiting

Extracellular Impact of Ultrasound-induced Blood-brain Barrier Disruption

This study seeks to determine the impact of focused ultrasound (FUS) on the composition of the tumor extracellular microenvironment. Researchers will evaluate regions that are very abnormal, as well a...

Rochester, MI6 participantsMayo Clinic

View Study Details

About Brain Cancer Clinical Trials in Rochester

Brain cancer includes tumors that originate in the brain (primary) or spread from other areas (metastatic). Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Treatment typically combines surgery, radiation, and chemotherapy, with immunotherapy trials underway.

There are currently 25 brain cancer clinical trials recruiting participants in Rochester, MI. These studies are seeking a combined 8,974 participants. Research is being sponsored by Adela, Inc, Patrick Wen, MD, Mayo Clinic and 8 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Brain Cancer Clinical Trials in Rochester — FAQ

Are there brain cancer clinical trials in Rochester?

Yes, there are 25 brain cancer clinical trials currently recruiting in Rochester, MI. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Rochester?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Rochester research site will contact you about next steps.

Are clinical trials in Rochester free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Rochester studies also compensate for your time and travel.

What brain cancer treatments are being tested?

The 25 active trials in Rochester are testing new therapies including novel drugs, biologics, and treatment approaches for brain cancer.

Data updated July 13, 2026 from ClinicalTrials.gov