56 Osteogenesis Imperfecta Clinical Trials in Rochester, NY (2026)

Q: How do I join a clinical trial in Rochester?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Rochester research site will contact you.

Recruiting Osteogenesis Imperfecta Studies in Rochester

NCT06192875Recruiting

A Novel Molecular Approach to Blood DNA Screening for Cancer: Specificity Assessment (The NOMAD Study)

This study is being done to establish "normal' values for a new blood test and urine test approach to cancer screening. Patients undergo blood and urine sample collection on study. Patients' medical r...

Rochester, NY10,000 participantsMayo Clinic

View Study Details

NCT06304168Recruiting

Validation of DNA Methylation Markers for Universal and Site-specific Guided Cancer Detection, VANGUARD Study

This study explores the potential value of a new blood test approach for early detection of cancer....

Rochester, NY6,150 participantsMayo Clinic

View Study Details

NCT07325006Recruiting

Impact of Physician Behavior on Cancer Distress

This evaluates the impact of physician behaviors and other factors experienced during radiation treatment influence distress levels in cancer patients....

Rochester, NY5,000 participantsMayo Clinic

View Study Details

NCT05112614Recruiting

Role of Gut Microbiome in Cancer Therapy

This study examines how gut microbiome can affect cancer therapy in cancer patients undergoing cancer therapy or stem cell transplant. The human microbiome affects the way some cancer drugs are metabo...

Rochester, NY3,000 participantsMayo Clinic

View Study Details

NCT02958462Recruiting

Pre-myeloid Cancer and Bone Marrow Failure Clinic Study

This clinical trial tests next generation sequencing (NGS) for the detection of precursor features of pre-myeloid cancers and bone marrow failure syndromes. NGS is a procedure that looks at relevant c...

Rochester, NY2,000 participantsMayo Clinic

View Study Details

NCT06465810Recruiting

Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

The MaesTTRo study aims to enroll a global cohort of patients with transthyretin (ATTR) amyloidosis to longitudinally observe the natural course of the disease and describe real-world treatment patter...

Rochester, NY1,850 participantsAstraZeneca

View Study Details

NCT02523118Recruiting

OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages

The purpose of this observational study is to find the best measures to define how well a person with eosinophilic disorder is doing. People with EoE, EoG, EoN and EoC normally undergo endoscopy and/o...

Rochester, NY1,350 participantsChildren's Hospital Medical Center, Cincinnati

View Study Details

NCT06353191Recruiting

Biomarkers to Predict Cancer Therapy-related Cardiotoxicity

This study evaluates why some cancer patients but not others experience changes in heart function following treatment with chemotherapy....

Rochester, NY1,000 participantsMayo Clinic

View Study Details

NCT01376024Recruiting

Study on Basal Joint Arthritis Prospective

The data in this prospective registry will be used 1) to define which surgical and nonoperative techniques are most effective at providing pain relief, restoring function, are cost effective, and pati...

Rochester, NY800 participantsColumbia University

View Study Details

NCT06198010Recruiting

A Collaborative Intervention for Improving Cancer Pain Management in Cancer Survivors

This clinical trial tests a collaborative pain management intervention (ASCENT) for improving cancer pain in cancer survivors. Cancer pain is prevalent, under-treated, and remains a major cause of suf...

Rochester, NY660 participantsMayo Clinic

View Study Details

NCT06207188Recruiting

Identification and Differentiation of Thyroid Nodules by Acoustic Imaging and Viscoelastic Parameters

This study is being done to identify and differentiate thyroid nodules by acoustic imaging and viscoelastic parameters....

Rochester, NY650 participantsMayo Clinic

View Study Details

NCT01873924Recruiting

Clinical and Neuropsychological Investigations in Batten Disease

This study aims to assess the natural history of Batten disease (Neuronal Ceroid Lipofuscinosis) by obtaining information about the motor, behavioral, and functional capabilities of individuals with B...

Rochester, NY500 participantsUniversity of Rochester

View Study Details

NCT05090345Recruiting

A Prospective Registry of Pediatric Cellular Therapy Patients at Risk for Endothelial Dysfunction, Sinusoidal Obstruction Syndrome and/or Multi-Organ Dysfunction Syndrome (MODS).

This is a prospective international multi-center registry and biorepository trial of children and adolescents/young adults (AYA) undergoing hematopoietic cell transplantation (HCT) to assess the impac...

Rochester, NY500 participantsDuke University

View Study Details

NCT07218705Recruiting

A Study Of MCG In Cardiac Amyloidosis

The primary objective of this observational study is to evaluate the utility of magnetocardiography (MCG) in diagnosing and monitoring disease progression in patients with amyloidosis, and to assess i...

Rochester, NY500 participantsMayo Clinic

View Study Details

NCT06015932Recruiting

Group Cognitive Behavior Sessions (CBCSM) to Decrease Distress in Cancer Patients

This clinical trial tests how well cognitive behavioral cancer stress management (CBCSM) group sessions work to decrease psychological distress in cancer patients. CBCSM teaches patients how to recogn...

Rochester, NY400 participantsMayo Clinic

View Study Details

NCT01311258Recruiting

Monitoring Minimal Residual Disease of Patients With Acute Myelogenous Leukemia or High Grade Myelodysplastic Syndrome

This study is being performed to develop assays to determine the impact of the therapy patients receive for treatment of AML or MDS and to determine if these tests can identify those patients who are ...

Rochester, NY400 participantsUniversity of Rochester

View Study Details

NCT06458335Recruiting

Intervening on Opioid Use and Loneliness

This study aims to enroll 300 participants who will be assigned to one of three 3 groups. Each group will receive an intervention lasting 6, weekly sessions of 40-60 minutes. Eligibility include havin...

Rochester, NY300 participantsUniversity of Rochester

View Study Details

NCT05732103Recruiting

A Study of CTX-712 in Relapsed/Refractory Acute Myeloid Leukemia and Higher Risk Myelodysplastic Syndromes

The goal of this phase 1/2 multicenter, open-label, single-arm dose escalation and expansion study is to assess the safety, tolerability, pharmacokinetic and pharmacodynamic profile of CTX-712 in pati...

Rochester, NY225 participantsChordia Therapeutics, Inc.

View Study Details

NCT06689956Recruiting

Outcomes of Low-Risk Endometrial Cancer With Isolated Tumor Cells in the Sentinel Lymph Nodes: A Prospective, Multicenter, Single-Arm Observational Study

This study evaluates whether isolated tumor cells in the first lymph nodes near the tumor can tell researchers something important about the future of patients with a certain type of endometrial (uter...

Rochester, NY212 participantsMayo Clinic

View Study Details

NCT05875805Recruiting

A Telehealth Advance Care Planning Intervention

The objective of this project is to conduct a pilot randomized trial to assess the preliminary efficacy of a telehealth-delivered Serious Illness Care Program on healthcare communication, patient anxi...

Rochester, NY207 participantsUniversity of Rochester

View Study Details

NCT05386615Recruiting

Post-Exablate Pregnancy Outcomes Registry Study: Exablate Treatment of Symptomatic Uterine Fibroids

The goal of this Registry Study is to capture clinical pregnancy outcomes and fibroid treatment background data for any subject post-Exablate treatment for their symptomatic fibroids....

Rochester, NY200 participantsInSightec

View Study Details

NCT06008795Recruiting

BLOCK-SAH - PPF-Block for Post-SAH Headache

BLOCK-SAH is a phase II, multicenter, randomized, double-blinded, placebo-controlled clinical trial with a sequential parallel comparison design (SPCD) of bilateral pterygopalatine fossa (PPF) injecti...

Rochester, NY195 participantsUniversity of Florida

View Study Details

NCT06872905Recruiting

Real-World Data Collection of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis When Used in Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) to Treat Aortoiliac Occlusive Disease

The study will assess the safety and effectiveness of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis ("VBX Device" or also referred to as "VBX Stent Graft") in a post approval setting and ev...

Rochester, NY158 participantsW.L.Gore & Associates

View Study Details

NCT06143631Recruiting

Prescription of Letrozole for Uterine Myoma

The PLUM Study is a randomized, double-blinded, 2-arm, parallel-group, placebo-controlled trial is designed to compare the efficacy of letrozole versus placebo on leiomyoma-related symptoms and qualit...

Rochester, NY140 participantsUniversity of California, San Francisco

View Study Details

NCT07477886Recruiting

Ambient Sensing Room to Detect Early Signs of Adverse Events in Hospitalized Patients With Cancer

This study uses ambient sensing rooms to collect data from hospitalized cancer patients in order to improve safety and recovery. Being hospitalized increases the risk for delirium (acute confusion), f...

Rochester, NY134 participantsMayo Clinic

View Study Details

NCT07223203Recruiting

TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy

The purpose of this study is to: * Determine the efficacy of nucresiran in patients with hATTR-PN by evaluating the effect on neurologic impairment, quality of life, nutritional status, disability, a...

Rochester, NY125 participantsAlnylam Pharmaceuticals

View Study Details

NCT06549790Recruiting

Study of NMS-03597812 in Adult Patients With Relapsed/Refractory Acute Myeloid Leukemia

The aim of PERKA-812-003 study is to investigate the safety, pharmacokinetics and preliminary anti-tumor activity of treatment with NMS-03597812 as single agent in Relapsed/Refractory Acute Myeloid Le...

Rochester, NY124 participantsNerviano Medical Sciences

View Study Details

NCT07263074Recruiting

Considering alloHCT: Opportunities for Patient Reflection During Decision-Making Via Digital Stories

This is a two-arm pilot randomized trial that assesses the feasibility and preliminary efficacy of a digital story and values clarification intervention (Considering alloHCT: Opportunities for Patient...

Rochester, NY120 participantsUniversity of Rochester

View Study Details

NCT06630234Recruiting

A Master Protocol to Evaluate DCC-3009 in Gastrointestinal Stromal Tumor (GIST)

The purpose of this Phase 1/2 master protocol study is to evaluate if DCC-3009 is safe, tolerable and works effectively in the treatment of GIST. The study will use a modular approach with each module...

Rochester, NY120 participantsDeciphera Pharmaceuticals, LLC

View Study Details

NCT06680037Recruiting

A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders

The main objective of the study is to determine the recommended phase 2 dose (RP2D) of Azercabtagene zapreleucel (azer-cel)....

Rochester, NY100 participantsTG Therapeutics, Inc.

View Study Details

NCT05898646Recruiting

Daratumumab Maintenance Therapy for Improving Survival in Patients With Light Chain Amyloidosis, EMILIA Trial

This phase II trial compares shorter-duration versus longer-duration maintenance therapy with daratumumab for improving survival in patients who have received initial treatment with daratumumab for li...

Rochester, NY96 participantsMayo Clinic

View Study Details

NCT06205121Recruiting

Efficacy and Safety Study of OATD-01 in Patients With Active Pulmonary Sarcoidosis

This is a Phase 2, randomized, double-blind, placebo-controlled, adaptive, multicenter study to evaluate the efficacy, safety, tolerability, Pharmacodynamics (PD), and Pharmacokinetics (PK) of OATD-01...

Rochester, NY96 participantsMolecure S.A.

View Study Details

NCT07081646Recruiting

A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.

Open-label Phase 1b/2 study with primary objective of this study is to evaluate the safety, tolerability and efficacy of AZD0120 in participants with light chain (AL) amyloidosis....

Rochester, NY91 participantsAlexion Pharmaceuticals, Inc.

View Study Details

NCT06432543Recruiting

Polyethylene Wear Particle Analysis of THA

Purpose of research The purpose of this study was to demonstrate that polyethylene (Vitamin E-containing polyethylene), a newly introduced biomaterial for tibial inserts in hip replacement surgery and...

Rochester, NY90 participantsOsaka Metropolitan University

View Study Details

NCT06279572Recruiting

Immune Profile of Acute Myeloid Leukemia Patients Receiving Azacitidine Plus Venetoclax Induction Chemotherapy

This study investigates the immune profile of patients receiving treatment with venetoclax plus azacitidine for acute myeloid leukemia (AML). Studying the information gathered from the immune profile ...

Rochester, NY80 participantsMayo Clinic

View Study Details

NCT06723041Recruiting

Acupressure for the Reduction of Anxiety in Patients Receiving Cancer-Directed Therapy

This clinicaI trial is being done to determine if acupressure is helpful to reduce anxiety related to chemotherapy, compared with "sham" (or placebo) acupressure in patients with cancer. Anxiety, expe...

Rochester, NY78 participantsMayo Clinic

View Study Details

NCT06158854Recruiting

A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Immunoglobulin Light Chain (AL) Amyloidosis Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion

Immunoglobulin light chain (AL) amyloidosis is the most common form of systemic amyloidosis. AL amyloidosis has many root causes and is characterized by the overproduction of AL that are secreted by c...

Rochester, NY76 participantsAbbVie

View Study Details

NCT07549698Recruiting

Safety and Preliminary Efficacy of CTX112 in Adult Participants With Relapsed/Refractory Hematologic Autoimmune Disease

This is a single-arm, open-label, multicenter, ascending dose Phase 1/2 trial evaluating the safety and preliminary efficacy of CTX112 or Zugocabtagene geleucel (zugo-cel) in adult participants with r...

Rochester, NY60 participantsCRISPR Therapeutics AG

View Study Details

NCT05995886Recruiting

Using Facebook to Support Opioid Recovery Among American Indian Women

The purpose of this study is to find out whether a Facebook group will help Native women in recovery from opioid use....

Rochester, NY60 participantsMayo Clinic

View Study Details

NCT06660732Recruiting

Rilonacept in Subjects With Cardiac Sarcoidosis

The primary objective of this study is to evaluate the effect of rilonacept, added to standard therapy and compared with standard therapy alone, on improvement in myocardial inflammation in subjects w...

Rochester, NY60 participantsMayo Clinic

View Study Details

NCT07250724Recruiting

C. Difficile Toxin Levels in Stool From Healthy Individuals Following Standard of Care Antibiotic Treatment for CDI.

Hospitals and clinics interested in participating in this multi-site study, please contact the people mentioned under "Contacts and Locations". The goal of this study is to map the risk of having a C...

Rochester, NY60 participantsBactolife A/S

View Study Details

NCT02923011Recruiting

Comparative Effectiveness of MRgFUS Versus CTgRFA for Osteoid Osteomas

Osteoid osteomas are painful, benign bone tumors that occur most frequently in young males between ages 10 and 20 years. The goal of the proposed study is based on the premise that MRgFUS is noninferi...

Rochester, NY56 participantsMatthew Bucknor

View Study Details

NCT06533098Recruiting

A Study of Nipocalimab or Intravenous Immunoglobulin (IVIG) in Pregnancies At Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

The purpose of this study is to assess the efficacy and safety of nipocalimab in reducing the risk of severe fetal and neonatal alloimmune thrombocytopenia (FNAIT)....

Rochester, NY50 participantsJanssen Research & Development, LLC

View Study Details

NCT05530759Recruiting

Examining Blood and Tissue Samples to Identify Diagnostic Markers in Patients With Metastatic Cancer Undergoing Tumor Removal

This study characterizes deoxyribonucleic acid (DNA) and proteomic (protein) changes in both biopsies and tumors removed during surgery of patients who have been diagnosed with aggressive/metastatic (...

Rochester, NY50 participantsMayo Clinic

View Study Details

NCT06712810Recruiting

Q702 for the Treatment of Patients With Hematologic Malignancies

This phase I trial tests the safety, side effects, and best dose of Q702 in treating patients with hematologic malignancies. Q702 is in a class of medications called immunomodulatory agents. It works ...

Rochester, NY46 participantsMayo Clinic

View Study Details

NCT07406633Recruiting

KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line)

This study will test an experimental drug called KQB198 in combination with imatinib. The goal is to determine if this combination is safe and tolerable and assess how effective the combination is at ...

Rochester, NY46 participantsKumquat Biosciences Inc.

View Study Details

NCT07291011Recruiting

A Mindfulness-Based Stress Reduction Program for Improving Mental Health Outcomes for Underserved Cancer Patients in Minnesota

This clinical trial evaluates whether a virtual stress reduction program that uses mindfulness-based stress reduction (MBSR) techniques works to improve mental health outcomes in cancer patients livin...

Rochester, NY45 participantsMayo Clinic

View Study Details

NCT05197530Recruiting

Imaging of Lymphatic Vessels in People With Rheumatoid Arthritis (RA)

Lymphatic transport was previously examined by these investigators using Near InfraRed Indocyanine Green fluorescence imaging (NIR-ICG) of the upper extremities. They established reliable and reproduc...

Rochester, NY40 participantsUniversity of Rochester

View Study Details

NCT07381179Recruiting

Voices: Messages of Wisdom and Hope in the Face of Illness

This study may help doctors determine where patients and caregivers may need more support and identify ways to maintain patient and caregiver dignity while undergoing treatment....

Rochester, NY40 participantsMayo Clinic

View Study Details

NCT05854303Recruiting

Effect of Opioid Cessation on Opioid-Induced Esophageal Dysfunction

The purpose of this study is to evaluate the effect of opioid cessation on opioid-induced esophageal dysfunction (OIED)....

Rochester, NY26 participantsMayo Clinic

View Study Details

NCT03964506Recruiting

Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant

The purpose of this study is to determine if hyperbaric oxygen therapy is safe in the setting of stem cell transplantation. This study will also determine if hyperbaric oxygen therapy improves engraft...

Rochester, NY24 participantsOmar Aljitawi

View Study Details

NCT05575440Recruiting

Evaluation of 18F-TFB PET/CT Scan in Patients With Differentiated Thyroid Cancer

This phase II study evaluates F-18 tetrafluoroborate (18F-TFB) PET/CT scan in patients with differentiated thyroid cancer. Diagnostic imaging is necessary for planning treatment, monitoring therapy re...

Rochester, NY24 participantsMayo Clinic

View Study Details

NCT06643884Recruiting

Suprachoroidal Administration in Subjects With Choroidal Metastasis From Breast or Lung Primary Tumors

The primary objective is to assess the safety and tolerability of bel-sar treatment in subjects with choroidal metastasis from breast or lung primary tumors....

Rochester, NY24 participantsAura Biosciences

View Study Details

NCT07216469Recruiting

A Study Of Myocardial Stiffness In Amyloidosis With Magnetic Resonance Elastography

This is a prospective case control study to determine the feasibility and utility of myocardial stiffness assessment by cardiac magnetic resonance elastography (MRE) in patients with cardiac amyloidos...

Rochester, NY20 participantsMayo Clinic

View Study Details

NCT06106269Recruiting

Outcomes and Quality of Life Following Rectal Artery Embolization for Bleeding Internal Hemorrhoids

This study will assess how effective and safe rectal artery embolization works to treat symptomatic bleeding predominant internal hemorrhoids....

Rochester, NY20 participantsMayo Clinic

View Study Details

NCT06600659Recruiting

A Study to Determine Number of Patients Who Develop High Ammonia Levels After Receiving Recombinant Erwinia Asparaginase

This study evaluates the incidence of symptomatic hyperammonemia (high ammonia levels) in patients being treated with recombinant Erwinia asparaginase....

Rochester, NY10 participantsMayo Clinic

View Study Details

About Osteogenesis Imperfecta Clinical Trials in Rochester

Osteogenesis imperfecta is a group of genetic disorders mainly affecting the bones, causing them to break easily, often from little or no apparent cause. It is caused by defects in collagen production. Treatment includes bisphosphonates, physical therapy, and surgical rodding.

There are currently 56 osteogenesis imperfecta clinical trials recruiting participants in Rochester, NY. These studies are seeking a combined 38,488 participants. Research is being sponsored by Mayo Clinic, AstraZeneca, Children's Hospital Medical Center, Cincinnati and 23 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Osteogenesis Imperfecta Clinical Trials in Rochester — FAQ

Are there osteogenesis imperfecta clinical trials in Rochester?

Yes, there are 56 osteogenesis imperfecta clinical trials currently recruiting in Rochester, NY. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Rochester?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Rochester research site will contact you about next steps.

Are clinical trials in Rochester free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Rochester studies also compensate for your time and travel.

What osteogenesis imperfecta treatments are being tested?

The 56 active trials in Rochester are testing new therapies including novel drugs, biologics, and treatment approaches for osteogenesis imperfecta.

Data updated July 13, 2026 from ClinicalTrials.gov