16 Depression Clinical Trials in San Diego, CA (2026)

Q: How do I join a clinical trial in San Diego?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the San Diego research site will contact you.

Recruiting Depression Studies in San Diego

NCT03887715Recruiting

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multip...

San Diego, CANA6,800 participantsLivaNova

View Study Details

NCT07420205Recruiting

Sleep Health in U.S. Marines

The goal of this study is to test a sleep health program designed specifically for U.S. Marine Corps personnel. Researchers want to determine if this program helps Marines improve the participants sle...

San Diego, CAPHASE2860 participantsSan Diego State University

View Study Details

NCT06966401Recruiting

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

This study will evaluate the long-term safety and tolerability of NBI-1065845 as an adjunctive treatment in participants with MDD....

San Diego, CAPHASE3850 participantsNeurocrine Biosciences

View Study Details

NCT07076407Recruiting

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

X-NOVA3 is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of azetukalner as a monotherapy in adult participants ...

San Diego, CAPHASE3450 participantsXenon Pharmaceuticals Inc.

View Study Details

NCT06372964Recruiting

Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients

This is a multicenter, randomized, double-blind, placebo-controlled study in pediatric patients who are experiencing major depressive episodes (MDEs) associated with a primary diagnosis of bipolar I o...

San Diego, CAPHASE3384 participantsIntra-Cellular Therapies, Inc.

View Study Details

NCT07621237Recruiting

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

The goal of this clinical trial is to learn if a drug called TNX-102 SL works to treat moderate to severe major depressive disorder in adults. It will also learn about the safety of TNX-102 SL. The ma...

San Diego, CAPHASE2360 participantsTonix Pharmaceuticals, Inc.

View Study Details

NCT06223880Recruiting

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

This is a randomized, double-blind, active-controlled, multi-center study to evaluate the efficacy of AXS-05, compared to bupropion, in preventing the relapse of depressive symptoms in subjects with m...

San Diego, CAPHASE4350 participantsAxsome Therapeutics, Inc.

View Study Details

NCT07300969Recruiting

A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

The goal of this clinical trial is to learn if DT-101 can treat depression in adults. The effect of DT-101 will be compared to placebo. Subjects will attend the clinic every couple of weeks complete g...

San Diego, CAPHASE2300 participantsDraig Therapeutics Ltd

View Study Details

NCT06786624Recruiting

Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depression....

San Diego, CAPHASE3200 participantsNeurocrine Biosciences

View Study Details

NCT07553637Recruiting

ALTO-207 in Adults With Treatment-resistant Depression (TRD)

The purpose of this trial is to measure depressive symptoms following treatment with ALTO-207 compared with placebo in participants with TRD....

San Diego, CAPHASE2178 participantsAlto Neuroscience

View Study Details

NCT07592689Recruiting

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Ascend...

San Diego, CAPHASE3165 participantsDefinium Therapeutics US, Inc.

View Study Details

NCT07512284Recruiting

Mindfulness Engaged Neurostimulation for Depression (MEND II)

Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal c...

San Diego, CAPHASE2120 participantsUniversity of California, San Diego

View Study Details

NCT06678880Recruiting

Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction

The goal of this clinical trial is to learn more about mood, sleep, and activity during menopause. The main question it aims to answer is: can mood and sleep dysfunction in menopause be improved by re...

San Diego, CANA120 participantsUniversity of California, San Diego

View Study Details

NCT06938841Recruiting

Maintenance rTMS for Depression (Maitr-De)

Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising intervention for treatment-resistant depression (TRD), yet substantial uncertainties persist regarding its efficacy as a ...

San Diego, CANA75 participantsUniversity of California, San Diego

View Study Details

NCT06753123Recruiting

Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 2)

This study develops and tests a dynamic workplace-based depression intervention that is tailored to the specific social and behavioral needs of low-wage hospital service workers. The intervention invo...

San Diego, CANA10 participantsSan Diego State University

View Study Details

NCT07217223Recruiting

Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study

The investigators propose a single-arm, open-label study to evaluate the effectiveness, safety, tolerability and feasibility of at-home transcranial direct current stimulation (tDCS) as a treatment fo...

San Diego, CANA10 participantsUniversity of California, San Diego

View Study Details

About Depression Clinical Trials in San Diego

Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.

There are currently 16 depression clinical trials recruiting participants in San Diego, CA. These studies are seeking a combined 11,232 participants. Research is being sponsored by LivaNova, San Diego State University, Neurocrine Biosciences and 8 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Depression Clinical Trials in San Diego — FAQ

Are there depression clinical trials in San Diego?

Yes, there are 16 depression clinical trials currently recruiting in San Diego, CA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in San Diego?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the San Diego research site will contact you about next steps.

Are clinical trials in San Diego free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many San Diego studies also compensate for your time and travel.

What depression treatments are being tested?

The 16 active trials in San Diego are testing new therapies including novel drugs, biologics, and treatment approaches for depression.

Data updated July 17, 2026 from ClinicalTrials.gov