13 Depression Clinical Trials in San Francisco, CA (2026)

Q: How do I join a clinical trial in San Francisco?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the San Francisco research site will contact you.

Recruiting Depression Studies in San Francisco

NCT06966401Recruiting

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

This study will evaluate the long-term safety and tolerability of NBI-1065845 as an adjunctive treatment in participants with MDD....

San Francisco, CAPHASE3850 participantsNeurocrine Biosciences

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NCT07573150Recruiting

Pupillometry in Identifying Risk of Postoperative Opioid-induced Respiratory Depression in Children Undergoing Tonsillectomy

This study will evaluate whether quantitative pupillometry measurements can be used to identify children at risk for postoperative opioid-induced respiratory depression (OIRD) following tonsillectomy....

San Francisco, CA300 participantsNeurOptics Inc

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NCT06564818Recruiting

"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"

The purpose of this study is to examine the efficacy, safety, and tolerability of CYB003 compared to matching placebo as adjunctive treatment in participants with MDD....

San Francisco, CAPHASE3220 participantsCybin IRL Limited

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NCT07186816Recruiting

SUpport From PEeRs to Expand Access Study - Community

Investigators will evaluate the implementation of an evidence-based, Spanish-language, digital, cognitive-behavioral therapy (dCBT) intervention (SilverCloud) in the Mission community for Latino patie...

San Francisco, CANA213 participantsUniversity of California, Berkeley

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NCT06091527Recruiting

Treating Major Depression With Yoga Mono-therapy

The goal of this single-center, single-blind, randomized, controlled, parallel group, interventional trial is to evaluate antidepressant efficacy of yoga monotherapy of 12-weeks duration in 180 adults...

San Francisco, CANA180 participantsUniversity of California, San Francisco

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NCT07592689Recruiting

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Ascend...

San Francisco, CAPHASE3165 participantsDefinium Therapeutics US, Inc.

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NCT07115329Recruiting

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

The goal of this clinical trial is to learn if zelquistinel works to treat depression in adults. It will also learn about the safety of zelquistinel. The main questions it aims to answer are: Does ze...

San Francisco, CAPHASE2164 participantsSyndeio Biosciences, Inc

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NCT06080646Recruiting

Reward Processing and Depressive Subtypes: Identifying Neural Biotypes

Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related informat...

San Francisco, CA150 participantsSan Francisco Veterans Affairs Medical Center

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NCT02434393Recruiting

Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project

The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, ob...

San Francisco, CA120 participantsUniversity of Southern California

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NCT04061148Recruiting

Near Infrared Spectroscopy (NIRS) for Assessment of Depression

Develop a NIRSIT testing protocol that can be administered in the diagnostic setting and reliably distinguishes the symptoms and severity of depression, with the help of repeated measure (up to five v...

San Francisco, CANA90 participantsUniversity of California, San Francisco

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NCT06898788Recruiting

Probiotic Administration for Adolescent Depression

This double-blind, placebo-controlled clinical trial will examine the effect of probiotic Visbiome on the brain and gut microbiome of individuals 15 to 24 years of age....

San Francisco, CAEARLY_PHASE177 participantsUniversity of California, San Francisco

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NCT05194098Recruiting

Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression

Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward respons...

San Francisco, CANA45 participantsSan Francisco Veterans Affairs Medical Center

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NCT04004169Recruiting

Closed-Loop Deep Brain Stimulation for Major Depression

Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electric...

San Francisco, CANA12 participantsAndrew Krystal

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About Depression Clinical Trials in San Francisco

Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.

There are currently 13 depression clinical trials recruiting participants in San Francisco, CA. These studies are seeking a combined 2,586 participants. Research is being sponsored by Neurocrine Biosciences, NeurOptics Inc, Cybin IRL Limited and 7 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Depression Clinical Trials in San Francisco — FAQ

Are there depression clinical trials in San Francisco?

Yes, there are 13 depression clinical trials currently recruiting in San Francisco, CA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in San Francisco?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the San Francisco research site will contact you about next steps.

Are clinical trials in San Francisco free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many San Francisco studies also compensate for your time and travel.

What depression treatments are being tested?

The 13 active trials in San Francisco are testing new therapies including novel drugs, biologics, and treatment approaches for depression.

Data updated July 17, 2026 from ClinicalTrials.gov