19 Heart Failure Clinical Trials in San Francisco, CA (2026)

Q: How do I join a clinical trial in San Francisco?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the San Francisco research site will contact you.

Recruiting Heart Failure Studies in San Francisco

NCT06033950Recruiting

A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients with Heart Failure Who Are Intolerant or Not Eligible for Treatment with Steroidal Mineralocorticoid Receptor Antagonists

Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients with heart failure and reduced ejection fraction (HFrEF) who are intolerant or ineligible to receive tr...

San Francisco, CAPHASE32,600 participantsColorado Prevention Center

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NCT05934487Recruiting

PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

This is a prospective, multi-center, open label, randomized control clinical trial evaluating the safety and efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class II-III Heart Failure...

San Francisco, CANA1,750 participantsEndotronix, Inc.

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NCT06024746Recruiting

A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients with Heart Failure (CONFIRMATION-HF)

Combination therapy of finerenone plus empagliflozin will be compared to usual care to determine the efficacy and safety of treatment in patients hospitalized with heart failure....

San Francisco, CAPHASE31,500 participantsColorado Prevention Center

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NCT06526195Recruiting

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

The purpose of TEAM-HF IDE clinical trial is to evaluate safety and effectiveness of the HeartMate 3 LVAS compared to guideline directed medical therapy (GDMT) in a population of ambulatory advanced h...

San Francisco, CANA850 participantsAbbott Medical Devices

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NCT06678841Recruiting

ELEVATE-HFpEF Clinical Study

ELEVATE-HFpEF is a prospective, randomized, controlled, double-blinded, multi-center, global, interventional pivotal study evaluating the safety and efficacy of dual chamber personalized pacing compar...

San Francisco, CANA700 participantsMedtronic Cardiac Rhythm and Heart Failure

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NCT05685303Recruiting

Alleviant ALLAY-HF Study

Prospective, multicenter, randomized, sham-controlled, double blinded, adaptive study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the Alleviant ALV...

San Francisco, CANA700 participantsAlleviant Medical, Inc.

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NCT07084142Recruiting

Developing a Digital Aid to Improve ICD Decisions

Advanced heart failure, affecting 7 million Americans, has multiple causes and results in greatly increased risk of disability and death. A major problem is sudden cardiac death, when the damaged hear...

San Francisco, CANA600 participantsStanford University

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NCT07288398Recruiting

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

The purpose of this study is to assess the efficacy and safety of the study drug, levosimendan (given orally), compared to placebo in participants with pulmonary hypertension with heart failure with p...

San Francisco, CAPHASE3540 participantsTenax Therapeutics, Inc.

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NCT06378632Recruiting

AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

Study Design: This is an international, multicenter, observational, non-interventional, prospective, blinded, single-arm, two-period study, to collect patient utterances that will be retrospectively ...

San Francisco, CA500 participantsCordio Medical

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NCT06812533Recruiting

Alleviant ALLAY-HFrEF Study

Prospective, multicenter, randomized, sham-controlled, double blind (patient and observer), study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the A...

San Francisco, CANA350 participantsAlleviant Medical, Inc.

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NCT05677100Recruiting

Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

Aortix is a circulatory support device for chronic heart failure patients on medical management who have been hospitalized for acute decompensated heart failure (ADHF) and have persistent congestion d...

San Francisco, CANA320 participantsProcyrion

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NCT06979362Recruiting

A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

This study will look into how CDR132L (a potential new medicine) works on the structure and function of the heart in people living with heart failure. Participants will either get CDR132L or placebo (...

San Francisco, CAPHASE2200 participantsNovo Nordisk A/S

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NCT04592445Recruiting

Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF

The purpose of this clinical study is to evaluate the safety and early effectiveness of a catheter-based procedure that treats a nerve called the right greater splanchnic nerve. The study includes peo...

San Francisco, CANA150 participantsAxon Therapies, Inc.

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NCT05034432Recruiting

The PIVATAL Study -Study of Ventricular Arrhythmia (VTA) Ablation in Left Ventricular Assist Device (LVAD) Patients

To investigate the effect of VTA ablation at the time of LVAD implant to see if it can reduce the incidence of VTA after surgery...

San Francisco, CAPHASE4100 participantsUniversity of Rochester

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NCT06793371Recruiting

AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF

This is a Phase 2 dose-finding study in adult participants with symptomatic HFpEF....

San Francisco, CAPHASE260 participantsCytokinetics

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NCT07443670Recruiting

Voice Analysis to Detect Pulmonary Arterial Pressure Changes in Heart Failure

VAPP-HF is a prospective, multi-center, observational study assessing whether daily voice recordings analyzed by a machine learning algorithm can detect changes in pulmonary arterial (PA) pressure in ...

San Francisco, CA60 participantsNoah Labs

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NCT07335510Recruiting

Impact of Barostimulation on Hemodynamics in Adults With Heart Failure

This study evaluates the effects of the implantation and adjustment of the CVRx Barostim device in adult patients with heart failure with reduced ejection fraction who are receiving maximally tolerate...

San Francisco, CANA58 participantsColumbia University

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NCT04703842Recruiting

Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction

It is believed that targeted SERCA2a enzyme replacement in HFrEF patients will correct defective intracellular Ca2+ hemostasis, resulting in improved cardiac contractile function and energetics which ...

San Francisco, CAPHASE157 participantsSardocor Corp.

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NCT06360380Recruiting

Reducing Fluid Overload in Heart Failure Patients Using a Non-invasive, Renal Independent System

The REFORM-HF study aims to test a new technology, AQUAPASS, designed to assist patients experiencing symptoms of fluid overload due to Heart Failure. Patients will wear a lightweight suit that helps...

San Francisco, CANA40 participantsAquaPass Medical Ltd.

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About Heart Failure Clinical Trials in San Francisco

Heart failure is a chronic condition where the heart cannot pump blood efficiently to meet the body's needs. It affects millions of people worldwide and can result from various heart conditions. Treatment includes medications, lifestyle changes, devices, and in severe cases, heart transplant.

There are currently 19 heart failure clinical trials recruiting participants in San Francisco, CA. These studies are seeking a combined 11,135 participants. Research is being sponsored by Colorado Prevention Center, Endotronix, Inc., Abbott Medical Devices and 14 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Heart Failure Clinical Trials in San Francisco — FAQ

Are there heart failure clinical trials in San Francisco?

Yes, there are 19 heart failure clinical trials currently recruiting in San Francisco, CA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in San Francisco?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the San Francisco research site will contact you about next steps.

Are clinical trials in San Francisco free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many San Francisco studies also compensate for your time and travel.

What heart failure treatments are being tested?

The 19 active trials in San Francisco are testing new therapies including novel drugs, biologics, and treatment approaches for heart failure.

Data updated September 1, 2026 from ClinicalTrials.gov