12 Melanoma Clinical Trials in San Francisco, CA (2026)

Q: How do I join a clinical trial in San Francisco?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the San Francisco research site will contact you.

Recruiting Melanoma Studies in San Francisco

NCT05727904Recruiting

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

This is a Phase 3, multicenter, open-label, randomized, parallel group, treatment study to assess the efficacy and safety of lifileucel in combination with pembrolizumab compared with pembrolizumab al...

San Francisco, CAPHASE3670 participantsIovance Biotherapeutics, Inc.

View Study Details

NCT07015190Recruiting

Neoadjuvant Darovasertib in Primary Uveal Melanoma

This is a Phase 3, randomized, multi-center, open-label study of neoadjuvant darovasertib in subjects with primary non-metastatic uveal melanoma (OptimUM-10)...

San Francisco, CAPHASE3520 participantsIDEAYA Biosciences

View Study Details

NCT06264180Recruiting

VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]

This is a randomized, controlled, multicenter, open-label Phase 3 clinical study comparing VO in combination with nivolumab versus Physician's Choice treatment for patients with unresectable Stage III...

San Francisco, CAPHASE3400 participantsReplimune Inc.

View Study Details

NCT06743126Recruiting

SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma

This clinical trial is a prospective, multicenter, open-label, randomized, actively controlled, parallel-group Phase 3 clinical trial to evaluate the efficacy, safety and tolerability of treatment wit...

San Francisco, CAPHASE3360 participantsImmatics US, Inc.

View Study Details

NCT03947385Recruiting

Study of IDE196 in Patients with Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

This is a Phase 1/2, multi-center, open-label basket study designed to evaluate the safety and anti-tumor activity of IDE196 in patients with solid tumors harboring GNAQ or GNA11 (GNAQ/11) mutations o...

San Francisco, CAPHASE1336 participantsIDEAYA Biosciences

View Study Details

NCT07148245Recruiting

Symptoms of Immune Checkpoint Inhibitor Therapy in Cutaneous Melanoma

The introduction of immune checkpoint inhibitors (ICIs) for the treatment of patients with stages IIB to IV cutaneous melanoma resulted in dramatic improvements in mortality rates for this common form...

San Francisco, CA300 participantsUniversity of California, San Francisco

View Study Details

NCT06961006Recruiting

A Clinical Study of V940 and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)

Researchers want to learn if V940 with pembrolizumab can stop advanced melanoma from growing or spreading. Melanoma is a type of skin cancer. Advanced means the cancer has spread to other parts of the...

San Francisco, CAPHASE2160 participantsMerck Sharp & Dohme LLC

View Study Details

NCT06624644Recruiting

A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma

The goal of this clinical trial is to understand if a new drug called LNS8801 can safely treat patients with melanoma. The primary question to be answered is what is the average length of time during ...

San Francisco, CAPHASE2135 participantsLinnaeus Therapeutics, Inc.

View Study Details

NCT07584226Recruiting

A First-in-human Study of RLY-8161 in Advanced NRAS-Mutant Solid Tumors

This is a Phase 1 first-in-human, open-label multicenter study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of RLY-8161, a...

San Francisco, CAPHASE135 participantsRelay Therapeutics, Inc.

View Study Details

NCT04598009Recruiting

Binimetinib and Imatinib for Unresectable Stage III-IV KIT-Mutant Melanoma

This phase II trial studies how well binimetinib and imatinib work in treating patients with stage III-IV KIT-mutant melanoma that cannot be removed by surgery (unresectable). Binimetinib and imatinib...

San Francisco, CAPHASE225 participantsUniversity of California, San Francisco

View Study Details

NCT06946225Recruiting

ACTengine® IMA203 Combined With mRNA-4203

This purpose of this clinical trial is to evaluate the safety, tolerability and anti-tumor activity of IMA203 in combination with different doses of mRNA-4203. The trial includes participants with pre...

San Francisco, CAPHASE115 participantsImmatics US, Inc.

View Study Details

NCT07237100Recruiting

Mirdametinib in Patients With Advanced NF1-mutant Melanoma

The goal of this clinical trial is to evaluate clinical efficacy of mirdametinib in patients with advanced NF1-mutant melanoma whose disease has progressed while on or after previous immunotherapy. Th...

San Francisco, CAPHASE210 participantsKevin Kim, MD

View Study Details

About Melanoma Clinical Trials in San Francisco

Melanoma is the most serious type of skin cancer, developing from the pigment-producing cells known as melanocytes. While less common than other skin cancers, melanoma is more likely to spread. Immunotherapy and targeted therapy have revolutionized melanoma treatment.

There are currently 12 melanoma clinical trials recruiting participants in San Francisco, CA. These studies are seeking a combined 2,966 participants. Research is being sponsored by Iovance Biotherapeutics, Inc., IDEAYA Biosciences, Replimune Inc. and 6 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Melanoma Clinical Trials in San Francisco — FAQ

Are there melanoma clinical trials in San Francisco?

Yes, there are 12 melanoma clinical trials currently recruiting in San Francisco, CA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in San Francisco?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the San Francisco research site will contact you about next steps.

Are clinical trials in San Francisco free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many San Francisco studies also compensate for your time and travel.

What melanoma treatments are being tested?

The 12 active trials in San Francisco are testing new therapies including novel drugs, biologics, and treatment approaches for melanoma.

Data updated September 2, 2026 from ClinicalTrials.gov