4 Depression Clinical Trials in San Jose, CA (2026)

Q: How do I join a clinical trial in San Jose?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the San Jose research site will contact you.

Recruiting Depression Studies in San Jose

NCT07196501Recruiting

A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

The primary objective of this study is to evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in delaying relapse of depressive symptoms (maintenance of effect) in pa...

San Jose, CAPHASE3550 participantsNeurocrine Biosciences

View Study Details

NCT06830044Recruiting

Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

The purpose of this study is to determine the efficacy and safety of milsaperidone compared to placebo as adjunctive therapy in patients with Major Depressive Disorder...

San Jose, CAPHASE3500 participantsVanda Pharmaceuticals

View Study Details

NCT07065240Recruiting

A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

This is a randomized, parallel-group, double-blind, placebo-controlled, monotherapy study to evaluate the efficacy, safety, and tolerability of SPT-300 (GlyphAllo) in adults with major depressive diso...

San Jose, CAPHASE2360 participantsSeaport Therapeutics

View Study Details

NCT07115329Recruiting

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

The goal of this clinical trial is to learn if zelquistinel works to treat depression in adults. It will also learn about the safety of zelquistinel. The main questions it aims to answer are: Does ze...

San Jose, CAPHASE2164 participantsSyndeio Biosciences, Inc

View Study Details

About Depression Clinical Trials in San Jose

Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.

There are currently 4 depression clinical trials recruiting participants in San Jose, CA. These studies are seeking a combined 1,574 participants. Research is being sponsored by Neurocrine Biosciences, Vanda Pharmaceuticals, Seaport Therapeutics and 1 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Depression Clinical Trials in San Jose — FAQ

Are there depression clinical trials in San Jose?

Yes, there are 4 depression clinical trials currently recruiting in San Jose, CA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in San Jose?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the San Jose research site will contact you about next steps.

Are clinical trials in San Jose free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many San Jose studies also compensate for your time and travel.

What depression treatments are being tested?

The 4 active trials in San Jose are testing new therapies including novel drugs, biologics, and treatment approaches for depression.

Data updated July 22, 2026 from ClinicalTrials.gov