Santa Monica, CALIFORNIA9 Active Studies

Advanced Solid Tumors Clinical Trials in Santa Monica, CALIFORNIA

Find 9 actively recruiting advanced solid tumors clinical trials in Santa Monica, CALIFORNIA. Connect with local research sites and explore new treatment options.

9
Active Trials
8
Sponsors
5,000
Enrolling

Recruiting Advanced Solid Tumors Studies in Santa Monica

RecruitingSanta Monica, CALIFORNIANCT03486873

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

The purpose of this study is to evaluate the long-term safety and efficacy of pembrolizumab (MK-3475) in participants from previous Merck pembrolizumab-based parent studies who transition into this ex...

3,500 participants
Merck Sharp & Dohme LLC
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RecruitingSanta Monica, CALIFORNIANCT05123482

A Phase I/IIa Study of AZD8205 Given Alone or in Combination With Anticancer Drugs, in Participants With Advanced or Metastatic Solid Malignancies

This research study is studying a new compound, AZD8205, as a possible treatment for advanced or metastatic solid tumours alone or in combination with anti-cancer agents...

370 participants
AstraZeneca
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RecruitingSanta Monica, CALIFORNIANCT04008797

A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor

The primary objective of this study is to assess the safety and tolerability and to determine the recommended Phase 2 dose (RP2D) of E7386 in combination with other anticancer drug(s), and to determin...

301 participants
Eisai Inc.
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RecruitingSanta Monica, CALIFORNIANCT04421820

BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours

BOLD-100 is an intravenously administered sterile solution containing the ruthenium-based small molecule. BOLD-100 has been shown to preferentially decrease the expression of GRP78 in tumour cells and...

220 participants
Bold Therapeutics, Inc.
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RecruitingSanta Monica, CALIFORNIANCT04106492

Phase 1/2a Study of SQ3370 in Patients With Advanced Solid Tumors

The purpose of this study is to evaluate the safety, tolerability, and preliminary activity of SQ3370 in patients with advanced solid tumors....

145 participants
Shasqi, Inc.
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RecruitingSanta Monica, CALIFORNIANCT04896697

Vilastobart (XTX101) Monotherapy and Vilastobart and Atezolizumab Combination Therapy in Advanced Solid Tumors

This is a first-in-human, Phase 1/2, multicenter, open-label study designed to evaluate the safety and tolerability of vilastobart (XTX101) as monotherapy and vilastobart (XTX101) and atezolizumab com...

136 participants
Xilio Development, Inc.
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RecruitingSanta Monica, CALIFORNIANCT05887492

Study of TNG260 and an Anti-PD Antibody in STK11 Mutated Solid Tumors

The goal of this interventional clinical trial is to learn about TNG260, a CoREST inhibitor, in combination with pembrolizumab in patients with advanced solid tumors with a known STK11 mutation. The ...

126 participants
Tango Therapeutics, Inc.
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RecruitingSanta Monica, CALIFORNIANCT06921928

Study for AZD4360 in Participants With Advanced Solid Tumours

The purpose of this study is to evaluate the safety, tolerability, PK, immunogenicity, pharmacodynamics, and preliminary efficacy of AZD4360 in adult participants with locally advanced or metastatic s...

117 participants
AstraZeneca
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RecruitingSanta Monica, CALIFORNIANCT06234098

Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmocodynamics and Preliminary Antitumor Activity of AT-1965 in Patients With Advanced, Refractory or Recurrent Solid Tumors

This is a first-in-human, multicenter, open-label, dose escalation and dose expansion Phase 1/2 study to determine the MTD and/or the recommended Phase 2 dose (RP2D) and to characterize DLTs of AT-196...

85 participants
Alyssum Therapeutics
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About Advanced Solid Tumors Clinical Trials in Santa Monica

Advanced solid tumors refer to cancers that have grown beyond the original site or spread to distant organs. Many clinical trials enroll patients with various types of advanced solid tumors to test novel therapies. These trials often investigate immunotherapy, targeted therapy, and combination approaches.

There are currently 9 advanced solid tumors clinical trials recruiting participants in Santa Monica, CALIFORNIA. These studies are seeking a combined 5,000 participants. Research is being sponsored by Merck Sharp & Dohme LLC, AstraZeneca, Eisai Inc. and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Advanced Solid Tumors Clinical Trials in Santa Monica — FAQ

Are there advanced solid tumors clinical trials in Santa Monica?

Yes, there are 9 advanced solid tumors clinical trials currently recruiting in Santa Monica, CALIFORNIA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Santa Monica?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Santa Monica research site will contact you about next steps.

Are clinical trials in Santa Monica free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Santa Monica studies also compensate for your time and travel.

What advanced solid tumors treatments are being tested?

The 9 active trials in Santa Monica are testing new therapies including novel drugs, biologics, and treatment approaches for advanced solid tumors.

Data updated March 2, 2026 from ClinicalTrials.gov