5 Depression Clinical Trials in Seattle, WA (2026)

Q: How do I join a clinical trial in Seattle?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Seattle research site will contact you.

Recruiting Depression Studies in Seattle

NCT06725277Recruiting

The OBSERVE Protocol

This observational protocol is intended to provide long-term follow-up data on patients initiating or continuing treatment with either Spravato® or IV ketamine. This can provide us information on the ...

Seattle, WA450 participantsYale University

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NCT06713616Recruiting

PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study

The purpose of this study is to compare the relative effectiveness, acceptability, and side effects of ketamine delivered through an IV (a drip into the arm) which is not currently FDA approved for us...

Seattle, WAPHASE3400 participantsYale University

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NCT04621877Recruiting

Lay-Delivered Behavioral Activation in Senior Centers

In response to large numbers of senior center clients who suffer untreated depression and the dearth of geriatric mental health providers, the investigators have simplified Behavioral Activation to be...

Seattle, WANA288 participantsUniversity of Washington

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NCT07226232Recruiting

Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression

The purpose of this multi-site randomized controlled trial is to evaluate the efficacy and risks of psilocybin for the treatment of depression in U.S. military Veterans with and without (±) concurrent...

Seattle, WAPHASE3240 participantsVA Office of Research and Development

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NCT06599099Recruiting

Deep Brain Stimulation of Treatment-Resistant Bipolar Depression

This study is only enrolling at Baylor College of Medicine. The other research locations listed serve to support data analysis only. This research study is to investigate the use of technology called...

Seattle, WANA10 participantsWayne Goodman MD

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About Depression Clinical Trials in Seattle

Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.

There are currently 5 depression clinical trials recruiting participants in Seattle, WA. These studies are seeking a combined 1,388 participants. Research is being sponsored by Yale University, University of Washington, VA Office of Research and Development and 1 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Depression Clinical Trials in Seattle — FAQ

Are there depression clinical trials in Seattle?

Yes, there are 5 depression clinical trials currently recruiting in Seattle, WA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Seattle?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Seattle research site will contact you about next steps.

Are clinical trials in Seattle free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Seattle studies also compensate for your time and travel.

What depression treatments are being tested?

The 5 active trials in Seattle are testing new therapies including novel drugs, biologics, and treatment approaches for depression.

Data updated August 27, 2026 from ClinicalTrials.gov