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NCT02901184RECRUITINGIRB Ready

Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction

(SPIRRIT)

Sponsored by Uppsala University

Quick Self-Assessment

See if you qualify and express your interest

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๐Ÿ“Š
1 of 2000 participants interested
0% interest

Express Your Interest Today

Interested in learning more? Complete the form below.

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Advance Medical Science

    Contribute to groundbreaking research

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel (varies by study)

  • Help Others

    Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3In-person assessment if eligible
  4. 4Begin participation

About This Study

Heart failure with preserved ejection fraction (HFPEF) is common and deadly but without therapy. Inconclusive studies such as TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) suggest spironolactone may be effective in HFPEF, but it is generic and will not be studied by industry.

Who Can Participate

Inclusion Criteria

Written informed consent
Age โ‰ฅ50 years
Stable heart failure defined by symptoms and signs of heart failure as judged by local Investigator
Left ventricular ejection fraction (LVEF) โ‰ฅ40% recorded in last 12 months (stratified to max 2/3rd in either 40-49% or โ‰ฅ50% group)
Elevated natriuretic peptide levels, as defined by any of the following: 1. most recent NT-proBNP \>300 ng/L (or BNP\>100 pg/mL) in sinus rhythm at time of blood sampling; adjustments may be made for BMI according to table 3. 2. most recent NT-proBNP \>750 ng/L (or BNP \>250 pg/mL) in atrial fibrillation at time of blood sampling; adjustments may be made for BMI according to table 3. 3. NT-proBNP \>1200 ng/L (or BNP \>400 pg/mL) within the last 12 months even if most recent value is lower.
Regular use of loop diuretics, defined as daily or most days of the week
NYHA Class II-IV

Exclusion Criteria

Previously enrolled in this study
Known Ejection Fraction \< 40% ever

โ“ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

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Study Type

INTERVENTIONAL

๐Ÿ‘ฅ

Target Enrollment

2000 participants

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Age Range

50 Years - 99 Years

โšง

Gender

ALL

๐Ÿข

Sponsor

Uppsala University

Study Locations

Choose your preferred location or select flexible during enrollment

TERMINATED

Alexander City

Alabama

Location available
View Alexander City location page
TERMINATED

Birmingham

Alabama

Location available
View Birmingham location page
TERMINATED

Tucson

Arizona

Location available
View Tucson location page
TERMINATED

Washington D.C.

District of Columbia

Location available
View Washington D.C. location page
TERMINATED

Washington D.C.

District of Columbia

Location available
View Washington D.C. location page
TERMINATED

Fort Lauderdale

Florida

Location available
View Fort Lauderdale location page
TERMINATED

Atlanta

Georgia

Location available
View Atlanta location page
TERMINATED

Marietta

Georgia

Location available
View Marietta location page
TERMINATED

Honolulu

Hawaii

Location available
View Honolulu location page

๐Ÿ“ And 29 more locations available

Frequently Asked Questions

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

Express your interest in this groundbreaking clinical trial

๐Ÿ”’ Secure ยท ๐Ÿฅ Expert Care

Looking for Heart Failure Treatment in Alexander City?

Join others in Alabama exploring innovative treatment options through clinical research

Heart Failure Treatment Options in Alexander City, Alabama

If you're searching for Heart Failure treatment in Alexander City, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in Alexander City, Birmingham, Tucson and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with Heart Failure. All study-related care is provided at no cost to participants.

Local Sites
3 locations in Alabama
Now Enrolling
Up to 2000 participants
Quick Start
Screening available now

Why Consider a Clinical Trial for Heart Failure?

Potential Benefits

  • โœ“Access to new treatment approaches before public availability
  • โœ“Close monitoring by experienced medical professionals
  • โœ“Study-related care provided at no cost
  • โœ“Contribute to medical research for Heart Failure

What to Expect

  • โ†’Initial screening to determine eligibility
  • โ†’Regular check-ups and monitoring visits
  • โ†’Possible compensation for time and travel
  • โ†’You can withdraw at any time

Frequently Asked Questions About This Heart Failure Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT02901184. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.