80 Active Studies

Fanconi Anemia Clinical Trials Near You

Find 80 actively recruiting fanconi anemia research studies near you. Connect with study sites, check eligibility, and explore new treatment options.

80
Active Trials
239+
Locations
125,665
Participants Needed

Recruiting Studies

RecruitingNCT00785525

Filgrastim-Mobilized Stem Cells for Transplantation Using Unrelated Donors

The purpose of the study is to: * Establish and evaluate a system for collection of filgrastim-mobilized peripheral blood stem cells from National Marrow Donor Program donors (NMDP) donors * Assess t...

4 locations(Boca Raton, Rockville, Minneapolis)
60,000 participants
Center for International Blood and Marrow Transplant Research
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RecruitingNCT06677060

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

Participants include men and women ≥ 40 years of age with T2DM, established CV disease, a history of HTN with an SBP of at least 130 mmHg at screening, who meet the predefined serum potassium level, a...

10 locations(Birmingham, Centreville, Fairhope)
11,300 participants
AstraZeneca
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RecruitingNCT06424288

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more...

10 locations(Mobile, Mobile, Chula Vista)
6,000 participants
Boehringer Ingelheim
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RecruitingNCT05636176

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

This study will be done to see if ziltivekimab can be used to treat people living with heart failure and inflammation. Participants will either get ziltivekimab or placebo. Participants will get study...

10 locations(Alexander City, Fairhope, Huntsville)
5,600 participants
Novo Nordisk A/S
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RecruitingNCT06008197

A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients hospitalized with acute decompensated heart failure (HF) and mildly reduced or preserved left ventricul...

4 locations(Aurora, Denver, Boca Raton)
5,200 participants
Colorado Prevention Center
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RecruitingNCT07037459

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

This study will examine if maridebart cafraglutide as an adjunct to standard of care will lead to a reduction in heart failure (HF) events such as HF hospitalizations and urgent HF visits, cardiovascu...

10 locations(Dothan, Fairhope, Huntsville)
5,056 participants
Amgen
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RecruitingNCT06307652

Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

This is a Phase III, international, multi-centre, randomised, double-blind, parallel-group, double-dummy, active-controlled, event-driven study in patients with chronic HF and impaired kidney function...

10 locations(Alexander City, Birmingham, Fairhope)
4,800 participants
AstraZeneca
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RecruitingNCT06935370

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with c...

10 locations(Mobile, Montgomery, Beverly Hills)
4,200 participants
Boehringer Ingelheim
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RecruitingNCT06033950

A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients with Heart Failure Who Are Intolerant or Not Eligible for Treatment with Steroidal Mineralocorticoid Receptor Antagonists

Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients with heart failure and reduced ejection fraction (HFrEF) who are intolerant or ineligible to receive tr...

8 locations(Fairhope, San Diego, Kansas City)
2,600 participants
Colorado Prevention Center
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RecruitingNCT06964464

Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator

This prospective, multicenter, open-label, randomized comparative effectiveness trial, titled CARVTOP-ICD, evaluates the impact of carvedilol versus metoprolol succinate in patients with heart failure...

10 locations(Scottsdale, Rome, Shawnee Mission)
2,000 participants
University of Rochester
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RecruitingNCT02901184

Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction

Heart failure with preserved ejection fraction (HFPEF) is common and deadly but without therapy. Inconclusive studies such as TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldo...

10 locations(Alexander City, Birmingham, Tucson)
2,000 participants
Uppsala University
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RecruitingNCT06736574

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

The purpose of this study is to find out if the investigational drug called omecamtiv mecarbil can reduce the risk of the effects of heart failure, like hospitalization, transplantation, or death in p...

10 locations(Alexander City, Birmingham, Tucson)
1,800 participants
Cytokinetics
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RecruitingNCT06024746

A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients with Heart Failure (CONFIRMATION-HF)

Combination therapy of finerenone plus empagliflozin will be compared to usual care to determine the efficacy and safety of treatment in patients hospitalized with heart failure....

10 locations(Fairhope, El Centro, Sacramento)
1,500 participants
Colorado Prevention Center
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RecruitingNCT06318169

A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)

The study will assess the efficacy and safety of 2 dose regimens of pegozafermin for the treatment of liver fibrosis stage 2 or 3 in adult participants with MASH (previously known as nonalcoholic stea...

10 locations(Birmingham, Chandler, Flagstaff)
1,050 participants
89bio, Inc.
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RecruitingNCT06876649

A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib

The master protocol study J2N-MC-JZNY provides a framework to enable the evaluation of the long-term safety and efficacy of pirtobrutinib after completion of clinical studies evaluating pirtobrutinib....

10 locations(Miami, Sarasota, Atlanta)
787 participants
Eli Lilly and Company
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RecruitingNCT06200207

A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation

The study is being done to see if ziltivekimab can be used to treat participants living with heart failure and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (ina...

10 locations(Alexander City, Fairhope, Little Rock)
680 participants
Novo Nordisk A/S
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RecruitingNCT06994442

Optimizing Pain Treatment in Children On Mechanical Ventilation

In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure. Right now, doctors give these children opioids to help wit...

10 locations(Little Rock, Washington D.C., Ann Arbor)
644 participants
Weill Medical College of Cornell University
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RecruitingNCT06991257

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF)....

10 locations(Beverly Hills, Lake Forest, Boca Raton)
620 participants
Pfizer
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RecruitingNCT04481919

Randomized Controlled Trial of urinE chemiStry Guided aCute heArt faiLure treATmEnt (ESCALATE)

This is a randomized trial of protocolized diuretic therapy guided by urinary sodium compared to structured usual care in ED patients with AHF. Participants will be recruited following an initial stan...

2 locations(Nashville, Nashville)
474 participants
Vanderbilt University Medical Center
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RecruitingNCT03996265

Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors

This phase III trial studies how well bupropion works in reducing cancer related fatigue in cancer survivors. Cancer and its treatment can cause fatigue. Bupropion is a drug that is used to treat depr...

10 locations(Anchorage, Anchorage, Anchorage)
422 participants
University of Rochester NCORP Research Base
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RecruitingNCT06033599

Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement

The purpose of this study is to 1) examine barriers and facilitators to implementation of MI and MORE for polysubstance use and evaluate strategies for optimizing training, fidelity, and clinic uptake...

2 locations(New Brunswick, Salt Lake City)
420 participants
Rutgers, The State University of New Jersey
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RecruitingNCT07000136

A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With HeFH

This is a study to evaluate the efficacy and safety of AZD0780 in adults with HeFH and elevated LDL-C, either with clinical ASCVD and LDL-C levels of 55 mg/dL or higher or without clinical ASCVD and L...

10 locations(Chula Vista, Garden Grove, Lake Forest)
405 participants
AstraZeneca
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RecruitingNCT06898515

Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)

The objective of this study is to prospectively compare decongestive therapy administered by the Reprieve System to Optimal Diuretic Therapy (ODT) in the treatment of patients diagnosed with acute dec...

10 locations(Irvine, Ann Arbor, St Louis)
400 participants
Reprieve Cardiovascular, Inc
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RecruitingNCT06237309

REGN5381 in Adult Participants With Heart Failure With Reduced Ejection Fraction

This study is researching an experimental drug called REGN5381 (called "study drug"). The study is focused on patients with heart failure with reduced ejection fraction (ie, the heart is not functioni...

10 locations(Phoenix, Torrance, Miami)
394 participants
Regeneron Pharmaceuticals
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RecruitingNCT06205225

iCardia4HF: Multi-component mHealth Intervention for Patients With Heart Failure

The goal of this factorial randomized trial is to examine the independent and synergistic efficacies of two mobile health technology interventions in people with chronic heart failure. The first inter...

2 locations(Chicago, Chicago)
360 participants
University of Illinois at Chicago
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RecruitingNCT05714085

Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

This study aims to compare the efficacy of vericiguat versus placebo on change in n-terminal pro-brain natriuretic peptide (NTproBNP) from baseline to Week 16 of the Base Period. The primary hypothesi...

10 locations(Loma Linda, Los Angeles, Aurora)
342 participants
Merck Sharp & Dohme LLC
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RecruitingNCT06349941

Home-based Cardiac Rehabilitation in Heart Failure

This study evaluates a mobile health (mHealth) home-based cardiac rehabilitation program for patients with heart failure. We will stratify randomization between rural and urban populations, with the g...

2 locations(Dallas, Dallas)
332 participants
University of Texas Southwestern Medical Center
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RecruitingNCT04787042

Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067

This is a multiphase, multicenter study, which includes a Phase 1a open-label, dose escalation monotherapy study of ST-067 given as an SC injection with or without obinutuzumab \[Gazyva®\] pre-treatme...

6 locations(Scottsdale, Denver, New Haven)
316 participants
Simcha IL-18, Inc.
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RecruitingNCT04005378

Disengagement in CSC: Identifying Those at Risk and Addressing Their Needs

Maintaining treatment engagement is critical for first episode psychosis patients to experience gains possible with coordinated specialty care (CSC). This study is designed to identify CSC participant...

3 locations(Lauderdale Lakes, Grand Rapids, Kalamazoo)
300 participants
Northwell Health
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RecruitingNCT05238519

Improved Diagnosis of Familial Hypercholesterolemia Across the Northland (ID-FH)

The overall goal of this study is to promote awareness of Familial Hypercholesterolemia (FH). The investigators aim to enroll patients with suspected FH into the study and will randomize them to recei...

2 locations(Duluth, Duluth)
300 participants
Essentia Health
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RecruitingNCT06017609

Evaluate Efficacy, Safety and Tolerability of JTT-861 in Subjects With Heart Failure With Reduced Ejection Fraction

This study will evaluate the efficacy, safety, tolerability and pharmacokinetics of JTT-861 administered once daily for 12 weeks in subjects with heart failure with reduced ejection fraction (HFrEF) w...

10 locations(Crystal River, Hialeah, Miami Lakes)
300 participants
Akros Pharma Inc.
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RecruitingNCT06369298

Study of JK07 in Patients With Chronic Heart Failure

This is a Phase 2, randomized, double-blind, placebo-controlled, multiple dose study to assess the safety, tolerability, and efficacy of JK07 in participants aged 18-85 with heart failure. There will...

10 locations(Alexander City, Birmingham, Birmingham)
282 participants
Salubris Biotherapeutics Inc
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RecruitingNCT04982419

Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial

This is a prospective, double-blind, sham-controlled, multicenter, randomized clinical trial is to study the effects of remote ischemic preconditioning on contrast-associated acute kidney injury, func...

3 locations(Pittsburgh, Dallas, Richmond)
240 participants
VA Office of Research and Development
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RecruitingNCT06734351

A Study to Assess Safety and Effectiveness of Injections of NOA VOLUME Injectable Gel in Adult Participants Compared to JUVÉDERM VOLUMA XC for Change of Mid-Face Volume

Facial fullness is often regarded as a characteristic feature of a youthful face. Chronic reduction of collagen, elastin, and glycosaminoglycans contribute to the facial volume loss that characterizes...

4 locations(Coral Gables, Metairie, Baltimore)
231 participants
AbbVie
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RecruitingNCT04301765

Improving Cancer-related Fatigue, Sexual Dysfunction and Quality of Life in Older Men With Cancer and Androgen Deficiency

This is a large randomized, double-blind, placebo-controlled trial to determine the efficacy of testosterone replacement on cancer-related fatigue in older men with solid or hematologic (blood) cancer...

3 locations(Augusta, Boston, Seattle)
230 participants
Seattle Institute for Biomedical and Clinical Research
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RecruitingNCT05858320

The Impact of an Adaptive Patient-centered Web Application on Medication Optimization in HFrEF Patients

The SmartHF study is a 12-week prospective randomized controlled multicenter clinical trial. This study will investigate the efficacy of an adaptive web application to facilitate guideline-directed me...

5 locations(Atlanta, Ann Arbor, Detroit)
225 participants
University of Michigan
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RecruitingNCT06122779

Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

The purpose of this study is to evaluate the safety, tolerability, and exposure-response (E-R) of BMS-986435/MYK-224 in participants with symptomatic Heart Failure with Preserved Ejection Fraction (HF...

10 locations(Birmingham, Lakewood, Jacksonville)
208 participants
Bristol-Myers Squibb
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RecruitingNCT04046497

Artificial Intelligence to Measure Adherence to Oral Medication

The aims of this project is to use an artificial intelligence (AI) smartphone app to provide support for medication adherence by patients with first episode psychosis....

5 locations(Hialeah, Grand Rapids, Kalamazoo)
200 participants
Northwell Health
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RecruitingNCT06979362

A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

This study will look into how CDR132L (a potential new medicine) works on the structure and function of the heart in people living with heart failure. Participants will either get CDR132L or placebo (...

10 locations(Birmingham, Tucson, Covina)
200 participants
Novo Nordisk A/S
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RecruitingNCT07038200

A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD

A Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous AOC 1020 for the Treatment of Facioscapulohumeral Muscular Dystrophy (FSHD)...

10 locations(Orange, Palo Alto, Denver)
200 participants
Avidity Biosciences, Inc.
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RecruitingNCT06616974

A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

TX000045-003 is a double-blind, randomized, parallel group, placebo-controlled, proof- of-concept (POC) study, evaluating 2 dose regimens of TX000045 over the course of a 24-week treatment period (the...

10 locations(Birmingham, Scottsdale, San Francisco)
180 participants
Tectonic Therapeutic
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RecruitingNCT06950385

Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis

The main goal of this clinical trial is to learn if the drug eRapa works to slow down the progression of disease in patients diagnosed with Familial Adenomatous Polyposis (FAP). Researchers will compa...

5 locations(Kansas City, Ann Arbor, Columbus)
168 participants
Rapamycin Holdings Inc.
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RecruitingNCT04862221

TReatment for ImmUne Mediated PathopHysiology

TReatment for ImmUne Mediated PathopHysiology (TRIUMPH) is a multi-center, three arm, randomized, controlled trial of immunosuppressive therapy for children with acute liver failure. The study will de...

10 locations(Los Angeles, Palo Alto, San Diego)
163 participants
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
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RecruitingNCT06395441

Wisconsin Ginseng for Decreasing Cancer Related Fatigue

This phase III trial compares the effect of Wisconsin ginseng (panax quinquefolius) to placebo in patients with cancer that suffer from significant fatigue. Fatigue is among the most challenging sympt...

10 locations(Albert Lea, Bemidji, Brainerd)
160 participants
Mayo Clinic
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RecruitingNCT06042153

DIALYSIS-TIR Study

This study will look at control of blood sugar levels in persons with type 2 diabetes mellitus currently on chronic dialysis. Researchers will compare blood sugar levels in people taking semaglutide t...

5 locations(Chapel Hill, Dallas, Dallas)
157 participants
University of Texas Southwestern Medical Center
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RecruitingNCT06317662

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

This phase II trial tests the addition of venetoclax and/or blinatumomab to usual chemotherapy for treating infants with newly diagnosed acute lymphoblastic leukemia (ALL) with a KMT2A gene rearrangem...

10 locations(Anchorage, Little Rock, Loma Linda)
153 participants
National Cancer Institute (NCI)
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RecruitingNCT05598333

Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects With Non-Ischemic NYHA Class III Heart Failure

This is a Phase 2 adaptive, double-blinded, placebo-controlled, randomized, multi-center trial study to evaluate the safety and efficacy of a single dose of AB-1002, administered via antegrade intraco...

10 locations(Birmingham, La Jolla, Clearwater)
150 participants
AskBio Inc
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RecruitingNCT06588699

Digoxin In NASH (CODIN)

Nonalcoholic steatohepatitis (NASH) is a severe subtype of nonalcoholic fatty liver disease (NAFLD) which affects 1 in 3 Americans. The mainstay of treatment for NASH, which was recently renamed metab...

2 locations(New Haven, New Haven)
144 participants
Yale University
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RecruitingNCT06055439

A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy

The goal of this clinical trial is to evaluate CHM-2101, an autologous CDH17 CAR T-cell therapy for the treatment of advanced gastrointestinal (GI) cancers that are relapsed or refractory to at least ...

4 locations(Atlanta, Chicago, Philadelphia)
135 participants
Chimeric Therapeutics
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RecruitingNCT06374875

Fibrosis Lessens After Metabolic Surgery

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), a major global public health concern, is commonly associated with obesity...

10 locations(Phoenix, Indianapolis, Rochester)
120 participants
Ali Aminian
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RecruitingNCT04551222

The Re-Prosper HF Study

Heart failure with reduced ejection fraction (HFrEF) is a common cause for admission within the Veterans Affairs (VA) Health Care System. It is associated with severe impairment of physical and menta...

5 locations(Boston, Cincinnati, Cleveland)
120 participants
VA Office of Research and Development
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RecruitingNCT06049680

Safety Study of SMOFlipid to Evaluate the Risk of Developing EFAD and/or PNAC in Pediatric and Adult Patients

Evaluate the risk of developing EFAD and/or PNAC in adult and pediatric patients 1 month of age and older, who are anticipated to need 8 weeks or longer of parenteral nutrition treatment with SMOFlipi...

4 locations(Atlanta, Chicago, Indianapolis)
100 participants
Fresenius Kabi
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RecruitingNCT02323399

Study to Determine the Pharmacokinetics and Pharmacodynamic Effects of Phenylephrine on BP Via IV

The primary objective of this study is to evaluate the dose effect of Phenylephrine Hydrochloride Injection on the treatment of clinically relevant decreased blood pressure in the pediatric population...

10 locations(Wilmington, Washington D.C., Miami)
100 participants
West-Ward Pharmaceutical
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RecruitingNCT05034432

The PIVATAL Study -Study of Ventricular Arrhythmia (VTA) Ablation in Left Ventricular Assist Device (LVAD) Patients

To investigate the effect of VTA ablation at the time of LVAD implant to see if it can reduce the incidence of VTA after surgery...

10 locations(Phoenix, Los Angeles, San Francisco)
100 participants
University of Rochester
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RecruitingNCT06783621

A Study to Evaluate Patient Satisfaction With the Overall Face and Neck Appearance After Combined Treatment of OnabotulinumtoxinA, JUVÉDERM® Products, KYBELLA, CoolSculpting Elite and SkinMedica Products

A study to evaluate overall participant satisfaction of face and neck appearance after treatment with onabotulinumtoxinA, JUVÉDERM® products, KYBELLA, CoolSculpting Elite, and select SkinMedica produc...

10 locations(Redondo Beach, Vista, Washington D.C.)
100 participants
AbbVie
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RecruitingNCT06753916

ExCrossV Multi Site Trial for Vascularized High Risk Keratoplasty

The main objective of this study is to determine the safety of Ex Vivo Cross Linking (CXL) of donor corneal tissue in participants who have undergone high-risk penetrating keratoplasty....

10 locations(Irvine, Los Angeles, San Francisco)
96 participants
Massachusetts Eye and Ear Infirmary
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RecruitingNCT05774665

Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression

The goal of this clinical trial is to determine the impact of omega-3 fatty acids on the production of anti-inflammatory effects and clinical improvement in people with depression who have not respond...

3 locations(Atlanta, Boston, Salt Lake City)
80 participants
Massachusetts General Hospital
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RecruitingNCT02143830

HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy

The purpose of this study is to determine whether the use of lower doses of busulfan and the elimination of cyclosporine will further reduce transplant-related side effects for patients with Fanconi A...

3 locations(New York, Cincinnati, Seattle)
70 participants
Children's Hospital Medical Center, Cincinnati
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RecruitingNCT05551793

Regeneron AA Multicenter (Dupilumab)

This is a prospective, randomized, double blind, placebo-controlled clinical trial. The study will take place at 4 sites. This trial will enroll a total of 68 patients with moderate to severe AA (affe...

3 locations(Irvine, New York, Rochester)
68 participants
Emma Guttman
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RecruitingNCT05552755

Evaluate REC-4881 in Patients With FAP

This is a multicenter, two-part trial in participants with Familial Adenomatous Polyposis (FAP)....

10 locations(Scottsdale, Tucson, San Diego)
67 participants
Recursion Pharmaceuticals Inc.
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RecruitingNCT05900050

Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)®

A Phase 2, multi-center, randomized, controlled, open-label study to evaluate the effects of the intraperitoneal, liposomal formulation VS-01 in patients with an acute episode of hepatic and/or extrah...

10 locations(Phoenix, Los Angeles, Sacramento)
60 participants
Versantis AG
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RecruitingNCT05004987

Aβ Dynamics in LLMD

This study will examine the biological factors that may modulate the relationship between depression and the development of Alzheimer's disease (AD). Since the direction of causation between depressio...

2 locations(New York, Orangeburg)
60 participants
NYU Langone Health
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RecruitingNCT06793371

AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF

This is a Phase 2 dose-finding study in adult participants with symptomatic HFpEF....

10 locations(Fairhope, Pasadena, Vista)
60 participants
Cytokinetics
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RecruitingNCT04703842

Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction

It is believed that targeted SERCA2a enzyme replacement in HFrEF patients will correct defective intracellular Ca2+ hemostasis, resulting in improved cardiac contractile function and energetics which ...

5 locations(San Diego, San Francisco, St Louis)
57 participants
Sardocor Corp.
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RecruitingNCT02934568

Ribociclib (LEE011) Rollover Study for Continued Access

This study is to allow continued use of ribociclib (LEE011) as single agent or in combination with other investigational treatments in patients benefitting from treatment in an eligible Novartis-spons...

10 locations(Birmingham, Boston, Ann Arbor)
50 participants
Novartis Pharmaceuticals
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RecruitingNCT04789044

Evaluating the Safety and Efficacy of Polyethylene Glycol (PEG) Mediated Fusion (PEG Fusion)

The overall objective of this study is to determine the safety of PEG fusion when used with primary repair or reconstruction in patients with an acute upper extremity peripheral nerve injury. PEG is s...

7 locations(Baltimore, Baltimore, Bethesda)
40 participants
Major Extremity Trauma Research Consortium
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RecruitingNCT06260059

Efficacy of Sodium Glucose Transporter Inhibitor (SGLT2I) in Adult Patients with Congenital Heart Disease

The goal of the study is to investigate the feasibility and benefit of novel guideline-directed heart failure therapy drug Empagliflozin (Jardiance) for adult patients with congenital heart disease (A...

3 locations(Pittsburgh, Pittsburgh, Pittsburgh)
40 participants
Anita Saraf
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RecruitingNCT05399537

Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT

Prismocitrate 18 is a continuous renal replacement therapy (CRRT) solution to be used as a renal replacement solution and as an anticoagulant to prevent blood clotting in the extracorporeal circuit. T...

10 locations(Birmingham, Los Angeles, Los Angeles)
40 participants
Vantive Health LLC
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RecruitingNCT05464784

MN-001 in Non-alcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus, and Hypertriglyceridemia

The design of the Phase 2 clinical trial includes the following elements: * Multi-center, two-arm, randomized, double-blind, placebo-controlled trial to evaluate MN-001 (tipelukast) vs. placebo in ap...

2 locations(Las Vegas, Edinburg)
40 participants
MediciNova
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RecruitingNCT05919680

A Study of NST-6179 in Subjects With Intestinal Failure-Associated Liver Disease (IFALD).

This is a phase 2a, multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of NST-6179 in subjects with ...

10 locations(Scottsdale, San Francisco, Washington D.C.)
36 participants
NorthSea Therapeutics B.V.
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RecruitingNCT06328608

A Study to Learn About the Safety and Effects of the Study Drug PRX-102 in Children and Adolescents With Fabry Disease

A Study to Learn About the Safety and Effects of the Study Drug PRX-102 in Children and Adolescents with Fabry Disease....

10 locations(Phoenix, Atlanta, Iowa City)
22 participants
Chiesi Farmaceutici S.p.A.
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RecruitingNCT05642455

SPEARHEAD-3 Pediatric Study

This is a pediatric basket study to investigate the safety and efficacy of afamitresgene autoleucel in HLA-A\*02 eligible and MAGE-A4 positive subjects aged 2-17 years of age with advanced cancers....

10 locations(Palo Alto, Bethesda, Boston)
20 participants
Adaptimmune
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RecruitingNCT06858397

A proof-of Concept Study to Assess Safety and Tolerability of HM15421/GC1134A in Patients With Fabry Disease

This Phase 1/2 first-in-human (FIH) study is designed to evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of HM15421 in patients with FD....

10 locations(Los Angeles, Kansas City, Minneapolis)
18 participants
GC Biopharma Corp
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RecruitingNCT04020055

A Study to Evaluate Migalastat in Fabry Subjects With Amenable GLA Variant and Renal Disease

An Open-label Study to Evaluate the Safety and Pharmacokinetics of Migalastat HCl in Subjects with Fabry Disease and Amenable GLA Variants and Severe Renal Impairment (SRI) or End Stage Renal Disease ...

10 locations(Atlanta, Cleveland, Dallas)
14 participants
Amicus Therapeutics
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RecruitingNCT06270316

Safety, PK/PD, and Exploratory Efficacy Study of AMT-191 in Classic Fabry Disease

The main goals of this clinical study are to characterize safety and PK/PD of AMT-191 i.e. if drug doses used in the study are safe and tolerable and to understand how it acts in the body of people wi...

8 locations(Birmingham, Atlanta, Chicago)
12 participants
UniQure Biopharma B.V.
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RecruitingNCT06541509

Mechanisms of Semaglutide Therapy in Heart Failure Patients

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, primarily used for treatment of type-2 diabetes mellitus. GLP-1 receptors are present on pancreatic islet β-cells, δ-cells and α-cell...

3 locations(Palo Alto, Stanford, Ljubljana)
10 participants
University Medical Centre Ljubljana
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RecruitingNCT03629340

Metformin for Pulmonary Hypertension HFpEF

The main objective of this study is to determine the clinical efficacy of metformin versus placebo and the therapeutic response with regards to functional capacity and hemodynamics in PH-HFpEF....

2 locations(San Francisco, Pittsburgh)
10 participants
University of California, San Francisco
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RecruitingNCT04289467

Treatment of Refractory Infantile Spasms With Fenfluramine

This is a phase II clinical trial in which children with refractory infantile spasms (also called epileptic spasms or West syndrome) will be treated with fenfluramine, to evaluate efficacy, safety, an...

2 locations(Los Angeles, Orange)
10 participants
Children's Hospital of Orange County
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RecruitingNCT06907875

A First-in-human Study of EPI-321 in Facioscapulohumeral Muscular Dystrophy

The goal of this clinical trial is to learn how safe and tolerable EPI-321 is and whether there may be early signs it is working in male or female adult (18 to 75 years) participants with facioscapulo...

5 locations(Los Angeles, Atlanta, Worcester)
9 participants
Epicrispr Biotechnologies, Inc.
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RecruitingNCT03500731

Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure

The purpose of this study is to determine whether a lung transplantation prior to bone marrow transplantation (BMT) would allow for restoration of pulmonary function prior to BMT, allowing to proceed ...

2 locations(Pittsburgh, Pittsburgh)
8 participants
Paul Szabolcs
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Top Cities for Fanconi Anemia Clinical Trials

Fanconi Anemia clinical trials are recruiting across 239 cities. Here are the cities with the most active studies:

About Fanconi Anemia

Fanconi anemia is a rare genetic disorder that affects bone marrow, reducing production of all types of blood cells and increasing cancer susceptibility. It is associated with physical abnormalities and organ defects. Treatment includes blood transfusions, growth factors, and stem cell transplant.

Clinical trials are advancing new treatments for fanconi anemia. Currently, 80 studies are recruiting a combined 125,665 participants across the United States. Research is being conducted by 67 organizations including Center for International Blood and Marrow Transplant Research, AstraZeneca, Boehringer Ingelheim and 64 others.

2026 Fanconi Anemia Research Landscape

As of March 2026, the fanconi anemia clinical trial landscape includes 80 actively recruiting studies across 239 cities in the United States. These studies are collectively seeking 125,665 participants, with an average enrollment target of 1,571 per study.

Research is being led by 67 different organizations, including Center for International Blood and Marrow Transplant Research, AstraZeneca, Boehringer Ingelheim, Novo Nordisk A/S, Colorado Prevention Center, and 62 others. The large number of sponsors reflects significant research interest and investment in fanconi anemia treatment advancement.

Geographically, fanconi anemia trials are most concentrated in Atlanta, Georgia (21 trials); Birmingham, Alabama (15 trials); Los Angeles, California (14 trials); New York, New York (12 trials); Boston, Massachusetts (12 trials) and 7 other cities.

Featured Fanconi Anemia Studies

Highlighted recruiting studies for fanconi anemia, selected by enrollment size and research scope.

RecruitingNCT00785525

Filgrastim-Mobilized Stem Cells for Transplantation Using Unrelated Donors

The purpose of the study is to: * Establish and evaluate a system for collection of filgrastim-mobilized peripheral blood stem cells from National Marrow Donor Program donors (NMDP) donors * Assess the safety among NMDP donors of filgrastim administration and PBSC leukapheresis * Assess the safety and efficacy of filgrastim-mobilized PBSC in unrelated donor hematopoietic stem cell transplant reci...

Sponsor: Center for International Blood and Marrow Transplant Research· 60,000 participants· 4 locations (Boca Raton, Rockville, Minneapolis, New York)
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RecruitingNCT06677060

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

Participants include men and women ≥ 40 years of age with T2DM, established CV disease, a history of HTN with an SBP of at least 130 mmHg at screening, who meet the predefined serum potassium level, and with at least one additional risk factor for HF. The study will include an optional pre-screening period to facilitate sites' identification of potentially eligible participants to enter the full ...

Sponsor: AstraZeneca· 11,300 participants· 10 locations (Birmingham, Centreville, Fairhope, Huntsville)
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RecruitingNCT06424288

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more. The purpose of this study is to find out whether vicadrostat (BI 690517) in combination with empagliflozin helps people with heart failure. Participants are put into 2 groups by chance. Every parti...

Sponsor: Boehringer Ingelheim· 6,000 participants· 10 locations (Mobile, Mobile, Chula Vista, Orange)
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Frequently Asked Questions About Fanconi Anemia Clinical Trials

Are there fanconi anemia clinical trials near me?

Yes, there are 80 fanconi anemia clinical trials currently recruiting across 239+ cities in the United States, including Atlanta, Georgia; Birmingham, Alabama; Los Angeles, California. Browse the studies above to find one at a location convenient for you.

How do I join a fanconi anemia clinical trial?

To join a fanconi anemia clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.

Are fanconi anemia clinical trials free?

Yes, participation in fanconi anemia clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.

What types of fanconi anemia treatments are being studied?

Current fanconi anemia clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 67 research organizations.

Is it safe to participate in fanconi anemia clinical trials?

Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.

Data updated March 1, 2026 from ClinicalTrials.gov

About This Data

Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.

Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.

Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov