NCT06033599 · Rutgers, The State University of New Jersey
Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement
What this study is about
The purpose of this study is to 1) examine barriers and facilitators to implementation of MI and MORE for polysubstance use and evaluate strategies for optimizing training, fidelity, and clinic uptake, and 2) evaluate patient outcomes related to the effectiveness of MORE decreasing opioid, tobacco, and other drug use.
View original scientific description
The purpose of this study is to 1) examine barriers and facilitators to implementation of MI and MORE for polysubstance use and evaluate strategies for optimizing training, fidelity, and clinic uptake, and 2) evaluate patient outcomes related to the effectiveness of MORE decreasing opioid, tobacco, and other drug use.
Interventions
OTHER
MORE and MI and NRT
Eight group Mindfulness Oriented Recovery Enhancement sessions and one motivational interviewing session and nicotine replacement therapy.
OTHER
MORE and No MI and NRT
Eight group Mindfulness Oriented Recovery Enhancement sessions and nicotine replacement therapy.
OTHER
Support Group and MI and NRT
Eight group support group sessions and one motivational interviewing session and nicotine replacement therapy.
OTHER
Support Group and No MI and NRT
Eight group support group sessions and and nicotine replacement therapy.
Primary outcome measures
Days of Drug Use
Time frame: Baseline through 52 weeks.
Number of days of drug use as measured by self-reported days of use and biochemically verified use via drug screen.
Days of Tobacco Use
Time frame: Baseline through 52 weeks.
Number of days of tobacco use as measured by self-reported days of use and biochemically verified use via expired carbon monoxide.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- English-speaking
- Currently on methadone; and 4) currently smoke cigarettes.
Exclusion criteria
- Severe cognitive impairment (score \>23 on Mini Mental Status Exam) or psychosis (positive SCID Psychotic Screen)
- Suicidal risk (score ≥7 on Suicidal Behaviors Questionnaire)
- Inability to attend or fully participate in intervention sessions or assessments
- Previous formal mindfulness training (e.g., MBSR, MBRP) or MORE (from the R21 or R33
- Currently taking smoking cessation pharmacotherapy or participating in smoking cessation counseling
- Any contraindications for NRT
- Currently or soon planning to be pregnant or breastfeeding.
Where
- New Brunswick, New Jersey
- Salt Lake City, Utah
Collaborators
University of Utah, National Institute on Drug Abuse (NIDA)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Apr 28, 2026 · Source of record for eligibility and locations