Is the study available in La Jolla, California?

Yes! This study has active research sites in La Jolla, Los Angeles, Sacramento. When you express interest, you'll be connected with the site nearest to you.

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NCT04262466RECRUITINGIRB Ready

Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors

Express Your Interest Today

Interested in learning more? Complete the form below.

First Name *

Last Name *

Email Address *

Phone Number *

ZIP Code *

Age Range *

Preferred Location

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

No-Cost Study Care
Advance Medical Science
Contribute to groundbreaking research
Cutting-Edge Treatment
Access to innovative therapies
Expert Medical Care
Close monitoring by specialists
Possible Compensation*
For time and travel (varies by study)
Help Others
Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

1Submit this form
2Phone screening
3In-person assessment if eligible
4Begin participation

About This Study

Brenetafusp (IMC-F106C) is an immune-mobilizing monoclonal T cell receptor against cancer (ImmTAC ®) designed for the treatment of cancers positive for the tumor-associated antigen PRAME. This is a first-in-human trial designed to evaluate the safety and efficacy of brenetafusp in adult participants who have the appropriate HLA-A2 tissue marker and whose cancer is positive for PRAME.

Who Can Participate

Inclusion Criteria

ECOG PS 0 or 1 2. HLA-A\*02:01 positive 3. PRAME positive tumor 4. Relapsed from, refractory to, or intolerant of standard therapies; or, in combination with standard therapies 5. If applicable, must agree to use highly effective contraception

Exclusion Criteria

Symptomatic or untreated central nervous system metastasis 2. Recent bowel obstruction 3. Ongoing ascites or effusion requiring recent drainages 4. Significant immune-mediated adverse event with prior immunotherapy (Participants in checkpoint inhibitor combination treatment) 5. Inadequate washout from prior anticancer therapy 6. Significant ongoing toxicity from prior anticancer treatment 7. Out-of-range laboratory values 8. Clinically significant lung, heart, or autoimmune disease 9. Ongoing requirement for immunosuppressive treatment 10. Prior solid organ or bone marrow transplant 11. Active hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV) infection 12. Sign

❓ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

📋

Study Type

INTERVENTIONAL

👥

Target Enrollment

727 participants

⚧

Gender

ALL

🏢

Sponsor

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

Express your interest in this groundbreaking clinical trial

🔒 Secure · 🏥 Expert Care

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Join others in California exploring innovative treatment options through clinical research

I cannot determine the primary medical condition from the provided information. The data only lists drug combinations and treatments, but does not specify what medical condition or disease these treatments are targeting. The brief summary appears to be incomplete (showing only "localhost:3000/trial/"), and there are no keywords provided that would indicate the underlying health condition being studied. Treatment Options in La Jolla, California

If you're searching for I cannot determine the primary medical condition from the provided information. The data only lists drug combinations and treatments, but does not specify what medical condition or disease these treatments are targeting. The brief summary appears to be incomplete (showing only "localhost:3000/trial/"), and there are no keywords provided that would indicate the underlying health condition being studied. treatment in La Jolla, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in La Jolla, Los Angeles, Sacramento and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with I cannot determine the primary medical condition from the provided information. The data only lists drug combinations and treatments, but does not specify what medical condition or disease these treatments are targeting. The brief summary appears to be incomplete (showing only "localhost:3000/trial/"), and there are no keywords provided that would indicate the underlying health condition being studied.. All study-related care is provided at no cost to participants.

Local Sites

3 locations in California

Now Enrolling

Up to 727 participants

Quick Start

Screening available now

Why Consider a Clinical Trial for I cannot determine the primary medical condition from the provided information. The data only lists drug combinations and treatments, but does not specify what medical condition or disease these treatments are targeting. The brief summary appears to be incomplete (showing only "localhost:3000/trial/"), and there are no keywords provided that would indicate the underlying health condition being studied.?

Potential Benefits

✓Access to new treatment approaches before public availability
✓Close monitoring by experienced medical professionals
✓Study-related care provided at no cost
✓Contribute to medical research for I cannot determine the primary medical condition from the provided information. The data only lists drug combinations and treatments, but does not specify what medical condition or disease these treatments are targeting. The brief summary appears to be incomplete (showing only "localhost:3000/trial/"), and there are no keywords provided that would indicate the underlying health condition being studied.

What to Expect

→Initial screening to determine eligibility
→Regular check-ups and monitoring visits
→Possible compensation for time and travel
→You can withdraw at any time

Frequently Asked Questions About This I cannot determine the primary medical condition from the provided information. The data only lists drug combinations and treatments, but does not specify what medical condition or disease these treatments are targeting. The brief summary appears to be incomplete (showing only "localhost:3000/trial/"), and there are no keywords provided that would indicate the underlying health condition being studied. Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT04262466. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.