Seattle, WANCT05642455Now EnrollingIRB Ready

I cannot determine the primary condition from the provided information. The only condition listed is "GENETIC:Afamitresgene autoleucel" which appears to be a treatment designation rather than a medical condition, and there are no keywords or meaningful summary details provided to identify what condition this pediatric study is actually treating. Clinical Trial in Seattle, WA

Access cutting-edge i cannot determine the primary condition from the provided information. the only condition listed is "genetic:afamitresgene autoleucel" which appears to be a treatment designation rather than a medical condition, and there are no keywords or meaningful summary details provided to identify what condition this pediatric study is actually treating. treatment through this clinical trial at a research site in Seattle. Study-provided care at no cost to qualified participants.

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All study-related i cannot determine the primary condition from the provided information. the only condition listed is "genetic:afamitresgene autoleucel" which appears to be a treatment designation rather than a medical condition, and there are no keywords or meaningful summary details provided to identify what condition this pediatric study is actually treating. treatment provided free

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Check if you qualify for this i cannot determine the primary condition from the provided information. the only condition listed is "genetic:afamitresgene autoleucel" which appears to be a treatment designation rather than a medical condition, and there are no keywords or meaningful summary details provided to identify what condition this pediatric study is actually treating. clinical trial in Seattle, WA

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  • Local to Seattle

    Convenient for WA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

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  1. 1Submit this form
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About This I cannot determine the primary condition from the provided information. The only condition listed is "GENETIC:Afamitresgene autoleucel" which appears to be a treatment designation rather than a medical condition, and there are no keywords or meaningful summary details provided to identify what condition this pediatric study is actually treating. Study in Seattle

This is a pediatric basket study to investigate the safety and efficacy of afamitresgene autoleucel in HLA-A\*02 eligible and MAGE-A4 positive subjects aged 2-17 years of age with advanced cancers.

Sponsor: Adaptimmune

Who Can Participate

Inclusion Criteria

Subject has histologically confirmed diagnosis of any one of the following cancers: (A) Synovial Sarcoma (SS), (B) MPNST, (C) Neuroblastoma, or (D) Osteosarcoma (OS).
Age: (A) Synovial Sarcoma: 2 to 17 years (B) MPNST, Neuroblastoma and Osteosarcoma: 2 to 21 years
Body weight ≥ 10 kg
Must have previously received a systemic chemotherapy
Measurable disease prior to lymphodepletion according to RECIST v1.1 (or INCR, 2017 Neuroblastoma only).
HLA-A\*02 positive
Tumor shows MAGE-A4 expression confirmed by central laboratory.
Performance Status: (A) Subjects ≥16: Eastern Cooperative Oncology Group (ECOG) 0 or 1 (B) Subjects 2 to 16: Lansky score ≥ 80 • Subject has anticipated life expectancy of greater than 3 months in the opinion of the investigator.

Exclusion Criteria

Positive for HLA-A\*02:05 in either allele; or any A\*02 having same protein sequence as HLA-A\*02:05
History of allergic reactions attributed to compounds of similar chemical

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Seattle?

Yes, this clinical trial (NCT05642455) has an active research site in Seattle, WA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

I cannot determine the primary condition from the provided information. The only condition listed is "GENETIC:Afamitresgene autoleucel" which appears to be a treatment designation rather than a medical condition, and there are no keywords or meaningful summary details provided to identify what condition this pediatric study is actually treating. Treatment Options in Seattle, WA

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Our Seattle research site is actively enrolling participants for this clinical trial. You'll receive care from experienced i cannot determine the primary condition from the provided information. the only condition listed is "genetic:afamitresgene autoleucel" which appears to be a treatment designation rather than a medical condition, and there are no keywords or meaningful summary details provided to identify what condition this pediatric study is actually treating. specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

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