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Repositioning Immunotherapy in VetArans With Lung Cancer

(RIVAL)

Sponsored by VA Office of Research and Development

Quick Self-Assessment

See if you qualify and express your interest

Preparing your pre-screening questions...

Current Status

Recruiting

Auto-verified from ClinicalTrials.gov

Verified Feb 28, 2025

Phase

Clinical Trial

Sponsor

VA Office of Research and Development

Enrollment Target

25

Start Date

Mar 2024

๐Ÿ“Š
1 of 25 participants interested
4% interest

Express Your Interest Today

Interested in learning more? Complete the form below.

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Advance Medical Science

    Contribute to groundbreaking research

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel (varies by study)

  • Help Others

    Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3In-person assessment if eligible
  4. 4Begin participation

About This Study

This study is a multicenter Phase II single arm trial to assess the safety and efficacy of chemotherapy and immunotherapy followed by radiotherapy in patients with unresectable Stage III NSCLC.

Who Can Participate

Inclusion Criteria

Participants must be more than 18 years of age.
Patient must have a performance status of 0-1 (ECOG Performance Scale).
Patient must be a candidate for concurrent chemoradiation.
Unresectable Stage III NSCLC as assessed by investigator or multidisciplinary tumor board assessment
PD-L1 tumor expression greater than or equal to 1%
Presence of measurable disease according to RECIST v1.1
Adequate organ function
Available tissue (archival FFPE preferred) with adequate tumor content ( 20% tumor cellularity).

Exclusion Criteria

Active autoimmune disease that has requires immunosuppressive therapy in the previous year.
Uncontrolled primary or acquired immunodeficiency (including HIV)
Baseline corticosteroid usage (\>10 mg prednisone or equivalent daily) aside from supportive medication use.
Tumor with known EGFR, ALK, ROS1, MET or RET mutations/fusions.
Presence of significant comorbidities precluding participation in a clinical study as determ

โ“ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

๐Ÿ“‹

Study Type

INTERVENTIONAL

๐Ÿ‘ฅ

Target Enrollment

25 participants

โšง

Gender

ALL

๐Ÿข

Sponsor

VA Office of Research and Development

Study Locations

Choose your preferred location or select flexible during enrollment

NOT_YET_RECRUITING

West Los Angeles

California

Location available
View West Los Angeles location page
RECRUITING

West Haven

Connecticut

Location available
View West Haven location page
RECRUITING

Ann Arbor

Michigan

Location available
View Ann Arbor location page
NOT_YET_RECRUITING

Omaha

Nebraska

Location available
View Omaha location page
NOT_YET_RECRUITING

Durham

North Carolina

Location available
View Durham location page
NOT_YET_RECRUITING

Cleveland

Ohio

Location available
View Cleveland location page
NOT_YET_RECRUITING

Richmond

Virginia

Location available
View Richmond location page

Frequently Asked Questions

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

Express your interest in this groundbreaking clinical trial

๐Ÿ”’ Secure ยท ๐Ÿฅ Expert Care

Find More Lung Cancer Trials by City

Browse all lung cancer clinical trials in these cities โ€” not just this study.

Looking for Lung Cancer Treatment in West Los Angeles?

Join others in California exploring innovative treatment options through clinical research

Lung Cancer Treatment Options in West Los Angeles, California

If you're searching for Lung Cancer treatment in West Los Angeles, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in West Los Angeles, West Haven, Ann Arbor and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with Lung Cancer. All study-related care is provided at no cost to participants.

Local Sites
3 locations in California
Now Enrolling
Up to 25 participants
Quick Start
Screening available now

Why Consider a Clinical Trial for Lung Cancer?

Potential Benefits

  • โœ“Access to new treatment approaches before public availability
  • โœ“Close monitoring by experienced medical professionals
  • โœ“Study-related care provided at no cost
  • โœ“Contribute to medical research for Lung Cancer

What to Expect

  • โ†’Initial screening to determine eligibility
  • โ†’Regular check-ups and monitoring visits
  • โ†’Possible compensation for time and travel
  • โ†’You can withdraw at any time

Frequently Asked Questions About This Lung Cancer Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT06275360. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.